Proconvulsant effect of bisphenol A in penicillin induced epileptiform activity

Gökhan ARSLAN; Erdal AĞAR

doi:https://doi.org/10.7197/223.vi.531144

Makale detayları

Proconvulsant effect of bisphenol A in penicillin induced epileptiform activity

Yazarlar:

Gökhan ARSLAN | Erdal AĞAR

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Cumhuriyet Medical Journal 2019 Vol.41 Issue 2, pp.244-249

Belge Tipi:

Makale

Yayın Tarihi:

6/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000922526

DOI:

https://doi.org/10.7197/223.vi.531144

Özet:

 


Objective: Epilepsy is a neurological disease characterized by
seizures that can affect all age groups. Experimental epilepsy models have been
used in order to prevent and treat epileptic seizures. Bisphenol A (BPA) is
found in the plastics that are used in our daily lives, and causes harmful
effects on the central nervous system. In this study, we aimed to investigate
the effect of BPA in penicillin-induced epileptiform activity.


Method: Male Wistar rats weighing 205 ± 220 grams were
separated into 4 groups: Control (n=7), 125 μg/kg BPA (n=7), 250 μg/kg BPA
(n=7) and 500 μg/kg BPA (n=7). Rats were anesthetized with urethane, and were fixed
to a stereotaxic device. With the stereotaxic guidance, an electrode was placed
over the left somotomotor cortex and it connected to the recorder. 500 IU
penicillin G was administered intracortically for induction of epileptiform
activity. After 30 minutes from penicillin injection, the doses of BPA or olive
oil were administered intraperitoneally and electrocorticography recording
continued for 180 minutes after drug injection.       


Results: BPA, at a dose of 125 μg/kg, did not significantly
change either the means of spike frequency or amplitude when compared to the
control group. BPA, at the doses of 250 and 500 μg/kg, showed proconvulsant
activity by increasing the mean spike frequency in the 50 and 40 minutes
(respectively) until the end of the experiment without changing the amplitude. 









Conclusions: The results of the present study provide
electrophysiological evidence that BPA increase the epileptiform activity.
Therefore, we suggest that epilepsy patients should avoid exposure to BPA.



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Makale detayları

Proconvulsant effect of bisphenol A in penicillin induced epileptiform activity

Yazarlar: Gökhan ARSLAN | Erdal AĞAR

Ana Başlıklar: Sağlık teşvikleri

Dergi: Cumhuriyet Medical Journal 2019 Vol.41 Issue 2, pp.244-249

Belge Tipi: Makale

Yayın Tarihi: 6/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000922526

DOI: https://doi.org/10.7197/223.vi.531144

Sayı

Yazarlar:

Gökhan ARSLAN | Erdal AĞAR

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Cumhuriyet Medical Journal 2019 Vol.41 Issue 2, pp.244-249

Belge Tipi:

Makale

Yayın Tarihi:

6/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000922526

DOI:

https://doi.org/10.7197/223.vi.531144