Hepatoprotective Activity of Indonesian Stingless Bee Propolis Against Toxicity of Anti-tuberculosis Drug on Pulmonary Tb Patients

Ahmad SULAEMAN; M MAHANI; HARDINSYAH HARDINSYAH; E DARMA; S. R. MUBAROKAH; N NURJANAH

Makale detayları

Hepatoprotective Activity of Indonesian Stingless Bee Propolis Against Toxicity of Anti-tuberculosis Drug on Pulmonary Tb Patients

Yazarlar:

Ahmad SULAEMAN | M MAHANI | HARDINSYAH HARDINSYAH | E DARMA | S. R. MUBAROKAH | N NURJANAH

Yayıncı:

Oktay YILDIZ

Dergi:

Journal of Apitherapy and Nature 2018 Vol.1 Issue 3, pp.10-10

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000492097

Sıklık:

İki Yıllık

eISSN:

2667-4734

Özet:

 


The usage of rifampicin,
isonoazid, pyrazinamide and ethambuthol to treat tuberculosis
(Tb) leads to hepatotoxicity which affects patient’s body weight
and nutritional status. Numerous studies have shown
propolis to act as a hepatoprotector. This study aimed to clinically evaluate the ability of propolis to protect the
liver from the toxic effects of anti tuberculosis drug
(ATD) and its impact on body weight and nutritional status changes of patients with pulmonary Tb. Randomized
clinical controlled trial, involving 50 subjects of lung Tb patients divided
into three groups: control (P0), propolis 1 supplementation (P1) and propolis 2 supplementation (P2); each subject
received intervention for 6 months. Biomarkers of liver toxicity; SGPT, SGOT,
BT, SOD and GSH were measured three times and body weight and nutritional
status were assessed weekly during treatment. Measurement of liver toxicity
biomarkers showed control groups experienced high liver oxidative damage during
the intensive treatment stage as characterized by
bilirubin exceeding normal values. In contrast, the
supplementation propolis groups showed no liver
oxidative damage as indicated by normal bilirubin
concentrations. P2 group showed excellent hepatoprotective activity as showed by the lowest bilirubin, the greatest
decrease of SGPT and the best antioxidant status of GSH and SOD enzymes. This
group also showed body weight and nutritional status increased from the beginning of the
intervention, while the other group decreased first. Pursuant to all
indicators, propolis 2 supplementation demonstrates liver protection from toxic
effects of OAT and prevents decreased body weight and nutritional status of
pulmonary Tb patients.

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Makale detayları

Hepatoprotective Activity of Indonesian Stingless Bee Propolis Against Toxicity of Anti-tuberculosis Drug on Pulmonary Tb Patients

Yazarlar: Ahmad SULAEMAN | M MAHANI | HARDINSYAH HARDINSYAH | E DARMA | S. R. MUBAROKAH | N NURJANAH

Yayıncı: Oktay YILDIZ

Dergi: Journal of Apitherapy and Nature 2018 Vol.1 Issue 3, pp.10-10

Belge Tipi: Makale

Yayın Tarihi: 12/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000492097

Sıklık: İki Yıllık

eISSN: 2667-4734

Sayı

Yazarlar:

Ahmad SULAEMAN | M MAHANI | HARDINSYAH HARDINSYAH | E DARMA | S. R. MUBAROKAH | N NURJANAH

Yayıncı:

Oktay YILDIZ

Dergi:

Journal of Apitherapy and Nature 2018 Vol.1 Issue 3, pp.10-10

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000492097

Sıklık:

İki Yıllık

eISSN:

2667-4734