Hepatoprotective effect of the ethyl acetate fraction of Indonesian Artocarpus species against CCl4 induced liver injury in rat

Fitrya Fitrya; Annisa Amriani; Rennie Puspa Novita

Makale detayları

Hepatoprotective effect of the ethyl acetate fraction of Indonesian Artocarpus species against CCl4 induced liver injury in rat

Yazarlar:

Fitrya Fitrya | Annisa Amriani | Rennie Puspa Novita

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 4, pp.952-960

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347013

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The liverthe center of metabolism and detoxificationis especially susceptible to damage from toxins and must be protected. This study aimed to evaluate the hepatoprotective effects of the ethyl acetate fraction from three Indonesian Artocarpus species Artocarpus altilis, A. champeden, and A. heterophyllus in rats with acute liver injury induced by carbon tetrachloride CCl4. The hepatoprotective effect was assessed through biochemical parameters AST, ALT, and ALP and histological analysis of the liver of the test group and compared to the normal control group Na CMC 0.5 and the positive control group silymarin 100 mgkg. There was no significant difference between the AST, ALT, and ALP levels in the 500 mg dose group, the control and the silymarin group p  0.05. Histological analysis of the liver tissue showed a microscopic profile similar to that of the control and silymarin groups. This study showed that the ethyl acetate fraction of Artocarpus altilis, A. heterophyllus, and A. champeden has synergistic potential as a hepatoprotector against liver injury caused by CCl4. Consequently, the leaves of these species can be used as complementary medicine in treating acute liver damage.

 The liverthe center of metabolism and detoxificationis especially susceptible to damage from toxins and must be protected. This study aimed to evaluate the hepatoprotective effects of the ethyl acetate fraction from three Indonesian Artocarpus species Artocarpus altilis, A. champeden, and A. heterophyllus in rats with acute liver injury induced by carbon tetrachloride CCl4. The hepatoprotective effect was assessed through biochemical parameters AST, ALT, and ALP and histological analysis of the liver of the test group and compared to the normal control group Na CMC 0.5 and the positive control group silymarin 100 mgkg. There was no significant difference between the AST, ALT, and ALP levels in the 500 mg dose group, the control and the silymarin group p  0.05. Histological analysis of the liver tissue showed a microscopic profile similar to that of the control and silymarin groups. This study showed that the ethyl acetate fraction of Artocarpus altilis, A. heterophyllus, and A. champeden has synergistic potential as a hepatoprotector against liver injury caused by CCl4. Consequently, the leaves of these species can be used as complementary medicine in treating acute liver damage.

 The liverthe center of metabolism and detoxificationis especially susceptible to damage from toxins and must be protected. This study aimed to evaluate the hepatoprotective effects of the ethyl acetate fraction from three Indonesian Artocarpus species Artocarpus altilis, A. champeden, and A. heterophyllus in rats with acute liver injury induced by carbon tetrachloride CCl4. The hepatoprotective effect was assessed through biochemical parameters AST, ALT, and ALP and histological analysis of the liver of the test group and compared to the normal control group Na CMC 0.5 and the positive control group silymarin 100 mgkg. There was no significant difference between the AST, ALT, and ALP levels in the 500 mg dose group, the control and the silymarin group p  0.05. Histological analysis of the liver tissue showed a microscopic profile similar to that of the control and silymarin groups. This study showed that the ethyl acetate fraction of Artocarpus altilis, A. heterophyllus, and A. champeden has synergistic potential as a hepatoprotector against liver injury caused by CCl4. Consequently, the leaves of these species can be used as complementary medicine in treating acute liver damage.

 The liverthe center of metabolism and detoxificationis especially susceptible to damage from toxins and must be protected. This study aimed to evaluate the hepatoprotective effects of the ethyl acetate fraction from three Indonesian Artocarpus species Artocarpus altilis, A. champeden, and A. heterophyllus in rats with acute liver injury induced by carbon tetrachloride CCl4. The hepatoprotective effect was assessed through biochemical parameters AST, ALT, and ALP and histological analysis of the liver of the test group and compared to the normal control group Na CMC 0.5 and the positive control group silymarin 100 mgkg. There was no significant difference between the AST, ALT, and ALP levels in the 500 mg dose group, the control and the silymarin group p  0.05. Histological analysis of the liver tissue showed a microscopic profile similar to that of the control and silymarin groups. This study showed that the ethyl acetate fraction of Artocarpus altilis, A. heterophyllus, and A. champeden has synergistic potential as a hepatoprotector against liver injury caused by CCl4. Consequently, the leaves of these species can be used as complementary medicine in treating acute liver damage.

Makale detayları

Hepatoprotective effect of the ethyl acetate fraction of Indonesian Artocarpus species against CCl4 induced liver injury in rat

Yazarlar:

Fitrya Fitrya | Annisa Amriani | Rennie Puspa Novita

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 4, pp.952-960

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347013

pISSN:

2630-6344

Ethyl acetate fraction

Artocarpus altilis

Artocarpus heterophyllus

Artocarpus champeden

acute liver damage

Sayı

Makale detayları

Hepatoprotective effect of the ethyl acetate fraction of Indonesian Artocarpus species against CCl4 induced liver injury in rat

Yazarlar: Fitrya Fitrya | Annisa Amriani | Rennie Puspa Novita

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.28 Issue 4, pp.952-960

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347013

pISSN: 2630-6344

Ethyl acetate fraction

Artocarpus altilis

Artocarpus heterophyllus

Artocarpus champeden

acute liver damage

Sayı

Yazarlar:

Fitrya Fitrya | Annisa Amriani | Rennie Puspa Novita

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 4, pp.952-960

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347013

pISSN:

2630-6344