Vasoactive use in early goal-directed therapy in dogs with severe sepsis and septic shock

Havva Süleymanoğlu; Kürşat Turgut; Merve Ertan; Mehmet Ege İnce; Amir Naseri

Makale detayları

Vasoactive use in early goal-directed therapy in dogs with severe sepsis and septic shock

Yazarlar:

Havva Süleymanoğlu | Kürşat Turgut | Merve Ertan | Mehmet Ege İnce | Amir Naseri

Yayıncı:

Ankara University

Ana Başlıklar:

Veterinary Medicine | Veterinary Surgery

Dergi:

Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.70 Issue 3, pp.327-335

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292294

pISSN:

1300-0861

Anahtar kelimeler:

Özet:

 The goal of this study was to see how to evaluate the changes in macrovascularand microvascular parameters in survivors Sv and non-survivors non-Sv dogs with severe sepsis and septic shock SEVS  SEPS in response to goal-directed hemodynamic optimization at the intensive care unit ICU, and to evaluate norepinephrine NE and dobutamine DT ICU applications, and their effectiveness for predicting death. Thirty-five dogs with SEVS  SEPS were used. NE was given to 10 hypotensive dogs, despite receiving a single bolus of fluid therapy, at a constant infusion rate of 1.5 µgkgmin for 2 h. The rate of NE infusion was doubled 3.0 µgkgmin if the clinical response was insufficient after 2 hours. DT was administered to 5 dogs with left ventricular systolic dysfunction LVSD LVS7.5 cms at a constant infusion rate of 5 µgkgmin for 2 h. The Sv and non-Sv groups had no major differences in macrovascular and microvascular characteristics, PW-TDI septal mitral annulus systolic S and early diastolic E velocities, or DT applications. The only difference was the use of NE applications. non-Sv received a greater amount of NE, while Sv received a smaller amount of NE. In contrast, more Sv received a greater amount of DT applications. Total mortality rate was 25.7. In conclusion, the effects of DT and NE in dogs with SEVS  SEPS are limited. To provide evidence-based guidelines for dogs with SEVS  SEPS, more research is needed.

 The goal of this study was to see how to evaluate the changes in macrovascularand microvascular parameters in survivors Sv and non-survivors non-Sv dogs with severe sepsis and septic shock SEVS  SEPS in response to goal-directed hemodynamic optimization at the intensive care unit ICU, and to evaluate norepinephrine NE and dobutamine DT ICU applications, and their effectiveness for predicting death. Thirty-five dogs with SEVS  SEPS were used. NE was given to 10 hypotensive dogs, despite receiving a single bolus of fluid therapy, at a constant infusion rate of 1.5 µgkgmin for 2 h. The rate of NE infusion was doubled 3.0 µgkgmin if the clinical response was insufficient after 2 hours. DT was administered to 5 dogs with left ventricular systolic dysfunction LVSD LVS7.5 cms at a constant infusion rate of 5 µgkgmin for 2 h. The Sv and non-Sv groups had no major differences in macrovascular and microvascular characteristics, PW-TDI septal mitral annulus systolic S and early diastolic E velocities, or DT applications. The only difference was the use of NE applications. non-Sv received a greater amount of NE, while Sv received a smaller amount of NE. In contrast, more Sv received a greater amount of DT applications. Total mortality rate was 25.7. In conclusion, the effects of DT and NE in dogs with SEVS  SEPS are limited. To provide evidence-based guidelines for dogs with SEVS  SEPS, more research is needed.

 The goal of this study was to see how to evaluate the changes in macrovascularand microvascular parameters in survivors Sv and non-survivors non-Sv dogs with severe sepsis and septic shock SEVS  SEPS in response to goal-directed hemodynamic optimization at the intensive care unit ICU, and to evaluate norepinephrine NE and dobutamine DT ICU applications, and their effectiveness for predicting death. Thirty-five dogs with SEVS  SEPS were used. NE was given to 10 hypotensive dogs, despite receiving a single bolus of fluid therapy, at a constant infusion rate of 1.5 µgkgmin for 2 h. The rate of NE infusion was doubled 3.0 µgkgmin if the clinical response was insufficient after 2 hours. DT was administered to 5 dogs with left ventricular systolic dysfunction LVSD LVS7.5 cms at a constant infusion rate of 5 µgkgmin for 2 h. The Sv and non-Sv groups had no major differences in macrovascular and microvascular characteristics, PW-TDI septal mitral annulus systolic S and early diastolic E velocities, or DT applications. The only difference was the use of NE applications. non-Sv received a greater amount of NE, while Sv received a smaller amount of NE. In contrast, more Sv received a greater amount of DT applications. Total mortality rate was 25.7. In conclusion, the effects of DT and NE in dogs with SEVS  SEPS are limited. To provide evidence-based guidelines for dogs with SEVS  SEPS, more research is needed.

 The goal of this study was to see how to evaluate the changes in macrovascularand microvascular parameters in survivors Sv and non-survivors non-Sv dogs with severe sepsis and septic shock SEVS  SEPS in response to goal-directed hemodynamic optimization at the intensive care unit ICU, and to evaluate norepinephrine NE and dobutamine DT ICU applications, and their effectiveness for predicting death. Thirty-five dogs with SEVS  SEPS were used. NE was given to 10 hypotensive dogs, despite receiving a single bolus of fluid therapy, at a constant infusion rate of 1.5 µgkgmin for 2 h. The rate of NE infusion was doubled 3.0 µgkgmin if the clinical response was insufficient after 2 hours. DT was administered to 5 dogs with left ventricular systolic dysfunction LVSD LVS7.5 cms at a constant infusion rate of 5 µgkgmin for 2 h. The Sv and non-Sv groups had no major differences in macrovascular and microvascular characteristics, PW-TDI septal mitral annulus systolic S and early diastolic E velocities, or DT applications. The only difference was the use of NE applications. non-Sv received a greater amount of NE, while Sv received a smaller amount of NE. In contrast, more Sv received a greater amount of DT applications. Total mortality rate was 25.7. In conclusion, the effects of DT and NE in dogs with SEVS  SEPS are limited. To provide evidence-based guidelines for dogs with SEVS  SEPS, more research is needed.

Makale detayları

Vasoactive use in early goal-directed therapy in dogs with severe sepsis and septic shock

Yazarlar: Havva Süleymanoğlu | Kürşat Turgut | Merve Ertan | Mehmet Ege İnce | Amir Naseri

Yayıncı: Ankara University

Ana Başlıklar: Veterinary Medicine | Veterinary Surgery

Dergi: Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.70 Issue 3, pp.327-335

Belge Tipi: Makale

Yayın Tarihi: 6/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001292294

pISSN: 1300-0861

dobutamine

early goal-directed therapy

norepinephrine

septic shock

severe sepsis

Sayı

Yazarlar:

Havva Süleymanoğlu | Kürşat Turgut | Merve Ertan | Mehmet Ege İnce | Amir Naseri

Yayıncı:

Ankara University

Ana Başlıklar:

Veterinary Medicine | Veterinary Surgery

Dergi:

Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.70 Issue 3, pp.327-335

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292294

pISSN:

1300-0861