Is Procalcitonin An Accurate Marker in the Diagnosis of Acinetobacter-Induced Bacteremia?

Ayşegül Seremet Keskin; Elif Sarıönder Gencer; Gülsüm İnce Toprak; Kübra Demir Önder

Makale detayları

Is Procalcitonin An Accurate Marker in the Diagnosis of Acinetobacter-Induced Bacteremia?

Yazarlar:

Ayşegül Seremet Keskin | Elif Sarıönder Gencer | Gülsüm İnce Toprak | Kübra Demir Önder

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Osmangazi Tıp Dergisi Vol.45 Issue 2, pp.275-281

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001283850

pISSN:

1305-4953

Anahtar kelimeler:

Özet:

 Nosocomial bloodstream infections are common in intensive care units, and a significant portion results in mortality. Procalcitonin is a biomarker used in the early diagnosis of bloodstream infections. Since different pathways release it, its level in the blood may differ in bloodstream infections caused by different agents. The present study was designed to demonstrate whether procalcitonin was an accurate marker in nosocomial bloodstream infections caused by Acinetobacter spp. The present study evaluated 214 bacteremia episodes of 145 patients diagnosed with nosocomial bloodstream infection. Nosocomial bloodstream infection agents were divided into four groups gram-positive bacteria, gram-negative bacteria, Acinetobacter spp., and Candida spp. At the time of diagnosis, procalcitonin, C-reactive protein, neutrophillymphocyte ratio, and leukocyte values were measured on the 3rd and 7th days. The mean procalcitonin value measured at the time of diagnosis was 11.721.8 ngml, the highest in the gram-negative bacteria group. The mean procalcitonin value in the gram-positive bacteria group was 2.86.44 ngml, 2.53.35 ngml in the Candida spp. group, and 3.512.1 ngml in the Acinetobacter spp. group. A significant difference was determined between the four groups regarding procalcitonin values. It was determined that the blood procalcitonin level at the time of diagnosis did not increase as expected in Acinetobacter spp.-induced nosocomial bloodstream infections. In this respect, caution should be exercised in the early diagnosis of nosocomial bloodstream infections.

 Nosocomial bloodstream infections are common in intensive care units, and a significant portion results in mortality. Procalcitonin is a biomarker used in the early diagnosis of bloodstream infections. Since different pathways release it, its level in the blood may differ in bloodstream infections caused by different agents. The present study was designed to demonstrate whether procalcitonin was an accurate marker in nosocomial bloodstream infections caused by Acinetobacter spp. The present study evaluated 214 bacteremia episodes of 145 patients diagnosed with nosocomial bloodstream infection. Nosocomial bloodstream infection agents were divided into four groups gram-positive bacteria, gram-negative bacteria, Acinetobacter spp., and Candida spp. At the time of diagnosis, procalcitonin, C-reactive protein, neutrophillymphocyte ratio, and leukocyte values were measured on the 3rd and 7th days. The mean procalcitonin value measured at the time of diagnosis was 11.721.8 ngml, the highest in the gram-negative bacteria group. The mean procalcitonin value in the gram-positive bacteria group was 2.86.44 ngml, 2.53.35 ngml in the Candida spp. group, and 3.512.1 ngml in the Acinetobacter spp. group. A significant difference was determined between the four groups regarding procalcitonin values. It was determined that the blood procalcitonin level at the time of diagnosis did not increase as expected in Acinetobacter spp.-induced nosocomial bloodstream infections. In this respect, caution should be exercised in the early diagnosis of nosocomial bloodstream infections.

 Nosocomial bloodstream infections are common in intensive care units, and a significant portion results in mortality. Procalcitonin is a biomarker used in the early diagnosis of bloodstream infections. Since different pathways release it, its level in the blood may differ in bloodstream infections caused by different agents. The present study was designed to demonstrate whether procalcitonin was an accurate marker in nosocomial bloodstream infections caused by Acinetobacter spp. The present study evaluated 214 bacteremia episodes of 145 patients diagnosed with nosocomial bloodstream infection. Nosocomial bloodstream infection agents were divided into four groups gram-positive bacteria, gram-negative bacteria, Acinetobacter spp., and Candida spp. At the time of diagnosis, procalcitonin, C-reactive protein, neutrophillymphocyte ratio, and leukocyte values were measured on the 3rd and 7th days. The mean procalcitonin value measured at the time of diagnosis was 11.721.8 ngml, the highest in the gram-negative bacteria group. The mean procalcitonin value in the gram-positive bacteria group was 2.86.44 ngml, 2.53.35 ngml in the Candida spp. group, and 3.512.1 ngml in the Acinetobacter spp. group. A significant difference was determined between the four groups regarding procalcitonin values. It was determined that the blood procalcitonin level at the time of diagnosis did not increase as expected in Acinetobacter spp.-induced nosocomial bloodstream infections. In this respect, caution should be exercised in the early diagnosis of nosocomial bloodstream infections.

 Nozokomiyal kan dolaşımı enfeksiyonları yoğun bakım ünitelerinde sık görülen ve önemli bir bölümü mortalite ile sonlanan enfeksiyonlardır. Prokalsitonin kan dolaşımı enfeksiyonların erken tanısında kullanılan bir biyobelirteçtir. Salınımının farklı yöntemlerle olması nedeni ile farklı etkenlerce oluşan kan dolaşımı enfeksiyonlarında kandaki seviyesi farklı düzeylerde olabilmektedir. Bizde Acinetobacter spp. etkenli nozokomiyal kan dolaşımı enfeksiyonlarında prokalsitonin iyi bir belirteç olup olmadığını göstermek amacı ile çalışmamızı planladık. Çalışmamızda nozokomiyal kan dolaşımı enfeksiyonu tanısı alan 145 hastanın 214 bakteriyemi epizodu değerlendirildi. Nozokomiyal kan dolaşımı enfeksiyonu etkenleri gram pozitif bakteriler, gram negatif bakteriler, Acinetobacter spp. ve Candida spp. olarak dört gruba ayrıldı. Tanı anında, 3. ve 7. günlerde prokalsitonin, C-reaktif protein, nötrofil lenfosit oranı ve lökosit değerlerine bakıldı. Tanı anında bakılan prokalsitonin değeri ortalaması 11,721,8 ngml ile en yüksek gram negatif bakteri grubunda idi. Gram pozitif STUDTbakteri grubunda ortalama prokalsitonin değeri 2,86,44 ngml, Candida spp. grubunda 2,53,35 ngml ve Acinetobacter spp. grubunda ise 3,512,1 ngml olarak tespit edildi. 4 grup arasında PCT değerleri açısından anlamlı fark saptandı. Acinetobacter spp. etkenli nozokomiyal kan dolaşımı enfeksiyonlarında tanı anında kan prokalsitonin düzeyi diğer etkenlere oranla beklenildiği kadar artmadığı tespit edilmiştir. Nozokomiyal kan dolaşımı enfeksiyonlarının erken tanısında bu açıdan dikkatli olunması gerektiğini düşünmekteyiz.

Makale detayları

Yazarlar: Ayşegül Seremet Keskin | Elif Sarıönder Gencer | Gülsüm İnce Toprak | Kübra Demir Önder

Yayıncı: Eskişehir Osmangazi University

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Osmangazi Tıp Dergisi Vol.45 Issue 2, pp.275-281

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001283850

pISSN: 1305-4953

Sayı

Yazarlar:

Ayşegül Seremet Keskin | Elif Sarıönder Gencer | Gülsüm İnce Toprak | Kübra Demir Önder

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Osmangazi Tıp Dergisi Vol.45 Issue 2, pp.275-281

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001283850

pISSN:

1305-4953