Role of hepcidin in the diagnosis of sepsis and septic shock in children

Osman YEŞİLBAŞ; Esra ŞEVKETOĞLU; Burcu Bursal DURAMAZ; Hasan Serdar KIHTIR; Asuman GEDİKBAŞI; Mey Talip PETMEZCİ; Canan BAYDEMİR

Makale detayları

Role of hepcidin in the diagnosis of sepsis and septic shock in children

Yazarlar:

Osman YEŞİLBAŞ | Esra ŞEVKETOĞLU | Burcu Bursal DURAMAZ | Hasan Serdar KIHTIR | Asuman GEDİKBAŞI | Mey Talip PETMEZCİ | Canan BAYDEMİR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 3, pp.517-524

Belge Tipi:

Makale

Yayın Tarihi:

5/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750706

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: The purpose of this study is to compare the diagnostic value of hepcidin level with the white blood cell (WBC),  C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels in pediatric sepsis and septic shock.  Materials and methods: A cohort of 89 individuals were divided into four groups: a healthy control group (HCG, n = 28), pediatric  intensive care unit control group (PICUCG, n = 17), sepsis group (SG, n = 23), and septic shock group (SSG, n = 21). WBC, CRP, PCT,  IL-6, and hepcidin levels were studied in the PICUCG, SG, and SSG, while hepcidin and IL-6 levels were studied in the HCG.  Results: In distinguishing the SG and SSG from the HCG, hepcidin sensitivity and specificity were found to be 100%. Distinguishing  between the PICUCG and the SG, hepcidin sensitivity was calculated as 95.6% and specificity was calculated as 100%. The sensitivity of  WBC, CRP, and PCT was lower than that of hepcidin, but the sensitivity of IL-6 was higher than that of hepcidin. While the specificity  of PCT and IL-6 was the same as hepcidin, the specificity of WBC and CRP was lower than that of hepcidin.  Conclusion: Hepcidin is a more reliable indicator than WBC and CRP levels in distinguishing children with sepsis and septic shock  from healthy children and nonseptic pediatric ICU patients.

Makale detayları

Role of hepcidin in the diagnosis of sepsis and septic shock in children

Yazarlar: Osman YEŞİLBAŞ | Esra ŞEVKETOĞLU | Burcu Bursal DURAMAZ | Hasan Serdar KIHTIR | Asuman GEDİKBAŞI | Mey Talip PETMEZCİ | Canan BAYDEMİR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 3, pp.517-524

Belge Tipi: Makale

Yayın Tarihi: 5/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000750706

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Osman YEŞİLBAŞ | Esra ŞEVKETOĞLU | Burcu Bursal DURAMAZ | Hasan Serdar KIHTIR | Asuman GEDİKBAŞI | Mey Talip PETMEZCİ | Canan BAYDEMİR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 3, pp.517-524

Belge Tipi:

Makale

Yayın Tarihi:

5/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750706

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144