Inflammatory biomarkers in Hashimoto’s thyroiditis: a comparative cross-sectional study

Muzaffer Deniz; Abdulvahap Coşkun

Makale detayları

Inflammatory biomarkers in Hashimoto’s thyroiditis: a comparative cross-sectional study

Yazarlar:

Muzaffer Deniz | Abdulvahap Coşkun

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Endokrinoloji | İç Hastalıkları

Dergi:

Anatolian Current Medical Journal Vol.7 Issue 3, pp.291-296

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349435

pISSN:

2718-0115

Anahtar kelimeler:

Özet:

 Aims: Hashimotos thyroiditis HT is an autoimmune disorder impacting majorly females. HT is asymptomatic long-term and known to be affected by metabolic factors, genetics, and inflammation. The study aimed to compare inflammatory and metabolic markers in HT and assess their value in the diagnosis. Methods: An HT group n103 and a control group with euthyroidism n103 were included in the study. The demographics, anthropometric measurements, and circulation-based inflammatory and metabolic markers, triglyceride-glucose index, FIB-4 score, non-alcoholic fatty liver disease score, APRI, ATH score, systemic immune-inflammation index, systemic inflammation response index, prognostic nutritional index, monocyte-to-HDL cholesterol ratio, atherogenic index of plasma, neutrophil-to lymphocyte ratio, platelet-to-lymphocyte ratio, PV, PDW, and RDW were recorded. Results: Consistent with the literature, we found a 10-fold difference in the HT prevalence in females 90.3 compared with males 9.7. Anthropometric measurements revealed that increased hip circumference increases the risk of HT 118.0 cm 107.0132.0 compared to control 110.0 cm 103.0119.0. We failed to find any difference in metabolic or inflammatory indices in the HT vs. control group. Conclusion: This study reinforces the well-documented association between HT and female predominance and metabolic factors such as obesity and diabetes. However, inflammatory markers did not show a significant association with HT, urging the need for larger cohorts.

 Aims: Hashimotos thyroiditis HT is an autoimmune disorder impacting majorly females. HT is asymptomatic long-term and known to be affected by metabolic factors, genetics, and inflammation. The study aimed to compare inflammatory and metabolic markers in HT and assess their value in the diagnosis. Methods: An HT group n103 and a control group with euthyroidism n103 were included in the study. The demographics, anthropometric measurements, and circulation-based inflammatory and metabolic markers, triglyceride-glucose index, FIB-4 score, non-alcoholic fatty liver disease score, APRI, ATH score, systemic immune-inflammation index, systemic inflammation response index, prognostic nutritional index, monocyte-to-HDL cholesterol ratio, atherogenic index of plasma, neutrophil-to lymphocyte ratio, platelet-to-lymphocyte ratio, PV, PDW, and RDW were recorded. Results: Consistent with the literature, we found a 10-fold difference in the HT prevalence in females 90.3 compared with males 9.7. Anthropometric measurements revealed that increased hip circumference increases the risk of HT 118.0 cm 107.0132.0 compared to control 110.0 cm 103.0119.0. We failed to find any difference in metabolic or inflammatory indices in the HT vs. control group. Conclusion: This study reinforces the well-documented association between HT and female predominance and metabolic factors such as obesity and diabetes. However, inflammatory markers did not show a significant association with HT, urging the need for larger cohorts.

 Aims: Hashimotos thyroiditis HT is an autoimmune disorder impacting majorly females. HT is asymptomatic long-term and known to be affected by metabolic factors, genetics, and inflammation. The study aimed to compare inflammatory and metabolic markers in HT and assess their value in the diagnosis. Methods: An HT group n103 and a control group with euthyroidism n103 were included in the study. The demographics, anthropometric measurements, and circulation-based inflammatory and metabolic markers, triglyceride-glucose index, FIB-4 score, non-alcoholic fatty liver disease score, APRI, ATH score, systemic immune-inflammation index, systemic inflammation response index, prognostic nutritional index, monocyte-to-HDL cholesterol ratio, atherogenic index of plasma, neutrophil-to lymphocyte ratio, platelet-to-lymphocyte ratio, PV, PDW, and RDW were recorded. Results: Consistent with the literature, we found a 10-fold difference in the HT prevalence in females 90.3 compared with males 9.7. Anthropometric measurements revealed that increased hip circumference increases the risk of HT 118.0 cm 107.0132.0 compared to control 110.0 cm 103.0119.0. We failed to find any difference in metabolic or inflammatory indices in the HT vs. control group. Conclusion: This study reinforces the well-documented association between HT and female predominance and metabolic factors such as obesity and diabetes. However, inflammatory markers did not show a significant association with HT, urging the need for larger cohorts.

 Aims: Hashimotos thyroiditis HT is an autoimmune disorder impacting majorly females. HT is asymptomatic long-term and known to be affected by metabolic factors, genetics, and inflammation. The study aimed to compare inflammatory and metabolic markers in HT and assess their value in the diagnosis. Methods: An HT group n103 and a control group with euthyroidism n103 were included in the study. The demographics, anthropometric measurements, and circulation-based inflammatory and metabolic markers, triglyceride-glucose index, FIB-4 score, non-alcoholic fatty liver disease score, APRI, ATH score, systemic immune-inflammation index, systemic inflammation response index, prognostic nutritional index, monocyte-to-HDL cholesterol ratio, atherogenic index of plasma, neutrophil-to lymphocyte ratio, platelet-to-lymphocyte ratio, PV, PDW, and RDW were recorded. Results: Consistent with the literature, we found a 10-fold difference in the HT prevalence in females 90.3 compared with males 9.7. Anthropometric measurements revealed that increased hip circumference increases the risk of HT 118.0 cm 107.0132.0 compared to control 110.0 cm 103.0119.0. We failed to find any difference in metabolic or inflammatory indices in the HT vs. control group. Conclusion: This study reinforces the well-documented association between HT and female predominance and metabolic factors such as obesity and diabetes. However, inflammatory markers did not show a significant association with HT, urging the need for larger cohorts.

Makale detayları

Inflammatory biomarkers in Hashimoto’s thyroiditis: a comparative cross-sectional study

Yazarlar:

Muzaffer Deniz | Abdulvahap Coşkun

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Endokrinoloji | İç Hastalıkları

Dergi:

Anatolian Current Medical Journal Vol.7 Issue 3, pp.291-296

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349435

pISSN:

2718-0115

Hashimoto thyroiditis

inflammatory markers

hip circumference

metabolic markers

Sayı

Makale detayları

Inflammatory biomarkers in Hashimoto’s thyroiditis: a comparative cross-sectional study

Yazarlar: Muzaffer Deniz | Abdulvahap Coşkun

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Endokrinoloji | İç Hastalıkları

Dergi: Anatolian Current Medical Journal Vol.7 Issue 3, pp.291-296

Belge Tipi: Makale

Yayın Tarihi: 5/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001349435

pISSN: 2718-0115

Hashimoto thyroiditis

inflammatory markers

hip circumference

metabolic markers

Sayı

Yazarlar:

Muzaffer Deniz | Abdulvahap Coşkun

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Endokrinoloji | İç Hastalıkları

Dergi:

Anatolian Current Medical Journal Vol.7 Issue 3, pp.291-296

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349435

pISSN:

2718-0115