Vitamin E as a novel therapy in the treatment of acute aluminum phosphide poisoning

Zahra HALVAEI; Hiva TEHRANI; Kambiz SOLTANINEJAD; Mohammad ABDOLLAHI; Shahin SHADNIA

Makale detayları

Vitamin E as a novel therapy in the treatment of acute aluminum phosphide poisoning

Yazarlar:

Zahra HALVAEI | Hiva TEHRANI | Kambiz SOLTANINEJAD | Mohammad ABDOLLAHI | Shahin SHADNIA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 3, pp.795-800

Belge Tipi:

Makale

Yayın Tarihi:

5/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751280

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Aluminum phosphide (AlP) is commonly used as a fumigant in developing countries. Induction of oxidative stress is one of the most important mechanisms of its toxicity. In this regard, and considering that there is no specific antidote for its treatment, the aim of this study was to evaluate the effect of vitamin E in the treatment of acute AlP poisoning.   Materials and methods: This was a clinical trial on acute AlP poisoned patients. All patients received supportive treatment. In addition, the treatment group received vitamin E (400 mg/BD/IM). Level of malondialdehyde (MDA) and total antioxidant capacity of plasma were measured.   Results: There was no significant difference between the treatment and control groups with regard to demographic, clinical, or paraclinical data or Simplified Acute Physiology Score II (SAPSII) on admission. Systolic blood pressure significantly increased during the first 24 h in the treatment group (P < 0.05). The plasma MDA level significantly decreased in the treatment group (P < 0.05). Vitamin E administration decreased the necessity (30% vs. 62%, P < 0.05) and duration of intubation and mechanical ventilation (P < 0.05). It significantly reduced the mortality rate in the treatment group compared to the control group (15% vs. 50%, respectively, P < 0.05).  Conclusion: Vitamin E along with supportive treatment could have a therapeutic effect in acute AlP poisoning.

Makale detayları

Vitamin E as a novel therapy in the treatment of acute aluminum phosphide poisoning

Yazarlar: Zahra HALVAEI | Hiva TEHRANI | Kambiz SOLTANINEJAD | Mohammad ABDOLLAHI | Shahin SHADNIA

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2017 Vol.47 Issue 3, pp.795-800

Belge Tipi: Makale

Yayın Tarihi: 5/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000751280

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Zahra HALVAEI | Hiva TEHRANI | Kambiz SOLTANINEJAD | Mohammad ABDOLLAHI | Shahin SHADNIA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 3, pp.795-800

Belge Tipi:

Makale

Yayın Tarihi:

5/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751280

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144