Diagnostic value of 3D power Doppler ultrasound in the characterization of thyroid nodules

Ayşegül CANSU; Emin AYAN; Sibel KUL; İlker EYÜBOGLU; Şükrü OĞUZ; Sevdegül MUNGAN

Makale detayları

Diagnostic value of 3D power Doppler ultrasound in the characterization of thyroid nodules

Yazarlar:

Ayşegül CANSU | Emin AYAN | Sibel KUL | İlker EYÜBOGLU | Şükrü OĞUZ | Sevdegül MUNGAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 3, pp.723-729

Belge Tipi:

Makale

Yayın Tarihi:

5/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000750065

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: This study aimed to evaluate the diagnostic value of vascular indices obtained using 3D power Doppler ultrasound (3D PDUS) in differentiation of benign and malignant thyroid nodules.Materials and methods: Sixty-seven patients (56 female, 11 male, mean age 44.6) with 81 thyroid nodules exhibiting mixed (peripheral and central) vascularization patterns, with the largest diameter between 10 and 30 mm, were prospectively evaluated using 3D PDUS. Nodule  volume,  vascularization  index  (VI),  flow  index  (FI),  and  vascularization  flow  index  (VFI)  were  calculated  using  the  Virtual  Organ  Computer-aided  Analysis  (VOCAL)  software,  and  these  indices  were  then  compared  with  regard  to  the  cytohistopathology-based  diagnosis.  The  optimum  cutoff  values  for  the  differentiation  of  benign  and  malignant  nodules  were  identified,  and  diagnostic  efficacy was calculated using receiver operating characteristic (ROC) analysis.Results: Fifty-six of the 81 nodules included in this study were diagnosed as benign and 25 as malignant. Vascular indices in malignant nodules were significantly higher than those in benign nodules (P < 0.05). In benign nodules, the mean VI was 11.61 ± 6.88, mean FI was 39.75 ± 3.93, and mean VFI was 4.82 ± 2.94, compared to 18.64 ± 12.81, 41.82 ± 4.43, and 8.17 ± 6.37, respectively, in malignant nodules. The area under the curves (AUCs) was calculated as 0.68, 0.61, and 0.67 for VI, FI, and VFI, respectively. At optimal cutoff values of 10.2 for VI, 40.8 for FI, and 5.5 for VFI, the sensitivity and specificity were 72%/55.4%, 68%/57.1%, and 68%/67.9%, respectively. Conclusion: 3D PDUS can be useful in the characterization of thyroid nodules.

Makale detayları

Diagnostic value of 3D power Doppler ultrasound in the characterization of thyroid nodules

Yazarlar: Ayşegül CANSU | Emin AYAN | Sibel KUL | İlker EYÜBOGLU | Şükrü OĞUZ | Sevdegül MUNGAN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 3, pp.723-729

Belge Tipi: Makale

Yayın Tarihi: 5/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000750065

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Ayşegül CANSU | Emin AYAN | Sibel KUL | İlker EYÜBOGLU | Şükrü OĞUZ | Sevdegül MUNGAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 3, pp.723-729

Belge Tipi:

Makale

Yayın Tarihi:

5/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000750065

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144