Antihypertensive and Renal Protective Effect of Bovine Lactoferrin in Dexamethasone-Induced Hypertension Rats

N.A.

Makale detayları

Antihypertensive and Renal Protective Effect of Bovine Lactoferrin in Dexamethasone-Induced Hypertension Rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 5, pp.1799-1807

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346773

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Current antihypertensive drugs are still limited to be used as a monotherapy and their effectiveness in preventing end-organ damage is insufficient, therefore complementary therapy is needed to reduce end-organ damage and make hypertension treatment more effective. In this study, we are investigating the potential of bovine lactoferrin BLf as an antihypertensive and renal protective agent. 30 rats were randomly divided into 6 groups: BLf 100mgkg, BLf 300 mgkg, BLf 500 mgkg, Dexamethasone, Amlodipine 1 mgkg, and Control. Dexamethasone, Amlodipine 1mgkg, and all BLf groups were given subcutaneous dexamethasone injections from day 1 to 14. Starting from day 8 to 14 Amlodipine 1 mgkg and BLf groups received oral BLf or amlodipine according to mentioned doses. The results of this study demonstrated that BLf at all doses was effective in lowering systolic blood pressure, increasing serum nitric oxide NO level, and improving kidney function but ineffective in lowering diastolic blood pressure. BLf has the potential to be utilized as a complementary antihypertensive therapy and renal protective agent in hypertension.

 Current antihypertensive drugs are still limited to be used as a monotherapy and their effectiveness in preventing end-organ damage is insufficient, therefore complementary therapy is needed to reduce end-organ damage and make hypertension treatment more effective. In this study, we are investigating the potential of bovine lactoferrin BLf as an antihypertensive and renal protective agent. 30 rats were randomly divided into 6 groups: BLf 100mgkg, BLf 300 mgkg, BLf 500 mgkg, Dexamethasone, Amlodipine 1 mgkg, and Control. Dexamethasone, Amlodipine 1mgkg, and all BLf groups were given subcutaneous dexamethasone injections from day 1 to 14. Starting from day 8 to 14 Amlodipine 1 mgkg and BLf groups received oral BLf or amlodipine according to mentioned doses. The results of this study demonstrated that BLf at all doses was effective in lowering systolic blood pressure, increasing serum nitric oxide NO level, and improving kidney function but ineffective in lowering diastolic blood pressure. BLf has the potential to be utilized as a complementary antihypertensive therapy and renal protective agent in hypertension.

 Current antihypertensive drugs are still limited to be used as a monotherapy and their effectiveness in preventing end-organ damage is insufficient, therefore complementary therapy is needed to reduce end-organ damage and make hypertension treatment more effective. In this study, we are investigating the potential of bovine lactoferrin BLf as an antihypertensive and renal protective agent. 30 rats were randomly divided into 6 groups: BLf 100mgkg, BLf 300 mgkg, BLf 500 mgkg, Dexamethasone, Amlodipine 1 mgkg, and Control. Dexamethasone, Amlodipine 1mgkg, and all BLf groups were given subcutaneous dexamethasone injections from day 1 to 14. Starting from day 8 to 14 Amlodipine 1 mgkg and BLf groups received oral BLf or amlodipine according to mentioned doses. The results of this study demonstrated that BLf at all doses was effective in lowering systolic blood pressure, increasing serum nitric oxide NO level, and improving kidney function but ineffective in lowering diastolic blood pressure. BLf has the potential to be utilized as a complementary antihypertensive therapy and renal protective agent in hypertension.

 Current antihypertensive drugs are still limited to be used as a monotherapy and their effectiveness in preventing end-organ damage is insufficient, therefore complementary therapy is needed to reduce end-organ damage and make hypertension treatment more effective. In this study, we are investigating the potential of bovine lactoferrin BLf as an antihypertensive and renal protective agent. 30 rats were randomly divided into 6 groups: BLf 100mgkg, BLf 300 mgkg, BLf 500 mgkg, Dexamethasone, Amlodipine 1 mgkg, and Control. Dexamethasone, Amlodipine 1mgkg, and all BLf groups were given subcutaneous dexamethasone injections from day 1 to 14. Starting from day 8 to 14 Amlodipine 1 mgkg and BLf groups received oral BLf or amlodipine according to mentioned doses. The results of this study demonstrated that BLf at all doses was effective in lowering systolic blood pressure, increasing serum nitric oxide NO level, and improving kidney function but ineffective in lowering diastolic blood pressure. BLf has the potential to be utilized as a complementary antihypertensive therapy and renal protective agent in hypertension.

Makale detayları

Antihypertensive and Renal Protective Effect of Bovine Lactoferrin in Dexamethasone-Induced Hypertension Rats

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.27 Issue 5, pp.1799-1807

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346773

pISSN: 2630-6344

bovine lactoferrin

nitric oxide

systolic blood pressure

diastolic blood pressure

renal protective

dexamethasone

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 5, pp.1799-1807

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346773

pISSN:

2630-6344