Evaluation of the Relationship between TLR1(RS4833095) Gene Polymorphism and Disease in Patients with Ulcerative Colitis in the Turkish Population

Dilek Çağlayan; Ramazan Dertli; Melek Çağlayan; Mahmut Selman Yıldırım; Hüseyin Ataseven

Makale detayları

Evaluation of the Relationship between TLR1(RS4833095) Gene Polymorphism and Disease in Patients with Ulcerative Colitis in the Turkish Population

Yazarlar:

Dilek Çağlayan | Ramazan Dertli | Melek Çağlayan | Mahmut Selman Yıldırım | Hüseyin Ataseven

Yayıncı:

Selcuk University

Ana Başlıklar:

Gastroenteroloji ve Hepatoloji

Dergi:

Genel Tıp Dergisi Vol.34 Issue 5, pp.603-608

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330462

pISSN:

2602-3741

Anahtar kelimeler:

Özet:

 Background: Ulcerative Colitis is a multifactorial disease which is characterized by recurrent periods of inflammation in the mucosal layer of the colon. Toll-like receptors TLRs are a class of transmembrane pattern recognition receptors that play a key role in the induction of proanti-inflammatory genes and in the control of adaptive immune responses. In this study, we aimed to evaluate the relation between TLR1rs4833095 single nucleotide polymorphism and ulcerative colitis. Methods: The study included 90 patients with ulcerative colitis and a healthy control group consisting of 90 people. Taken medical treatment, laboratory data, colonoscopy findings, extraintestinal manifestations of patients included in this study were recorded. TLR1rs4833095 single nucleotide polymorphism was studied with RT-PCR methods. Results: There was no increased risk for ulcerative colitis in patients with ulcerative colitis who has TLR1rs4833095 single nucleotide polymorphism in Turkish population p0.05. There was no association between TLR 1rs4833095 single nucleotide polymorphism and the spread of the disease in the colon, severity of disease and treatment required for remission in our studyp0.05. Conclusion: In the Turkish population, TLR1 rs4833095 single nucleotide polymorphism was evaluated and no significant difference was found between the patients with ulcerative colitis and the control group.

 Background: Ulcerative Colitis is a multifactorial disease which is characterized by recurrent periods of inflammation in the mucosal layer of the colon. Toll-like receptors TLRs are a class of transmembrane pattern recognition receptors that play a key role in the induction of proanti-inflammatory genes and in the control of adaptive immune responses. In this study, we aimed to evaluate the relation between TLR1rs4833095 single nucleotide polymorphism and ulcerative colitis. Methods: The study included 90 patients with ulcerative colitis and a healthy control group consisting of 90 people. Taken medical treatment, laboratory data, colonoscopy findings, extraintestinal manifestations of patients included in this study were recorded. TLR1rs4833095 single nucleotide polymorphism was studied with RT-PCR methods. Results: There was no increased risk for ulcerative colitis in patients with ulcerative colitis who has TLR1rs4833095 single nucleotide polymorphism in Turkish population p0.05. There was no association between TLR 1rs4833095 single nucleotide polymorphism and the spread of the disease in the colon, severity of disease and treatment required for remission in our studyp0.05. Conclusion: In the Turkish population, TLR1 rs4833095 single nucleotide polymorphism was evaluated and no significant difference was found between the patients with ulcerative colitis and the control group.

 Background: Ulcerative Colitis is a multifactorial disease which is characterized by recurrent periods of inflammation in the mucosal layer of the colon. Toll-like receptors TLRs are a class of transmembrane pattern recognition receptors that play a key role in the induction of proanti-inflammatory genes and in the control of adaptive immune responses. In this study, we aimed to evaluate the relation between TLR1rs4833095 single nucleotide polymorphism and ulcerative colitis. Methods: The study included 90 patients with ulcerative colitis and a healthy control group consisting of 90 people. Taken medical treatment, laboratory data, colonoscopy findings, extraintestinal manifestations of patients included in this study were recorded. TLR1rs4833095 single nucleotide polymorphism was studied with RT-PCR methods. Results: There was no increased risk for ulcerative colitis in patients with ulcerative colitis who has TLR1rs4833095 single nucleotide polymorphism in Turkish population p0.05. There was no association between TLR 1rs4833095 single nucleotide polymorphism and the spread of the disease in the colon, severity of disease and treatment required for remission in our studyp0.05. Conclusion: In the Turkish population, TLR1 rs4833095 single nucleotide polymorphism was evaluated and no significant difference was found between the patients with ulcerative colitis and the control group.

 Amaç: Ülseratif Kolit, kolonun mukozal tabakasında tekrarlayan inflamasyon dönemleri ile karakterize olan çok faktörlü bir hastalıktır. Toll benzeri reseptörler TLRler, proanti-inflamatuar genlerin uyarılmasında ve adaptif immün yanıtların kontrolünde anahtar rol oynayan transmembran, patern tanıma reseptörleridir. Bu çalışmada TLR1rs4833095 tek nükleotid polimorfizmi ile ülseratif kolit arasındaki ilişkiyi değerlendirmeyi amaçladık. Yöntem: Çalışmaya 90 ülseratif kolit hastası ve 90 kişiden oluşan sağlıklı kontrol grubu dahil edildi. Çalışmaya dahil edilen hastaların aldıkları tıbbi tedaviler, laboratuvar verileri, kolonoskopi bulguları, bağırsak dışı bulguları kaydedildi. TLR1rs4833095 tek nükleotid polimorfizmi RT-PCR yöntemiyle çalışıldı. Bulgular: Türk toplumunda TLR1rs4833095 tek nükleotid polimorfizmi olan ülseratif kolit hastalarında ülseratif kolit riskinde artış saptanmadı p0,05. Çalışmamızda TLR 1rs4833095 tek nükleotid polimorfizmi ile hastalığın kolondaki yayılımı, hastalığın şiddeti ve remisyon için gerekli tedavi arasında ilişki saptanmadıp0,05. Sonuç: Türk toplumunda TLR1 rs4833095 tek nükleotid polimorfizmi değerlendirilmiş ve ülseratif kolitli hastalar ile kontrol grubu arasında anlamlı fark saptanmamıştır.

Makale detayları

Evaluation of the Relationship between TLR1(RS4833095) Gene Polymorphism and Disease in Patients with Ulcerative Colitis in the Turkish Population

Yazarlar:

Dilek Çağlayan | Ramazan Dertli | Melek Çağlayan | Mahmut Selman Yıldırım | Hüseyin Ataseven

Yayıncı:

Selcuk University

Ana Başlıklar:

Gastroenteroloji ve Hepatoloji

Dergi:

Genel Tıp Dergisi Vol.34 Issue 5, pp.603-608

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330462

pISSN:

2602-3741

Ulcerative colitis

toll-like receptors

inflammatory bowel disease

single nucleotide polymorphism.: Ülseratif kolit

toll benzeri reseptörler

inflamatuar barsak hastalığı

tek nükleotid polimorfizmi.

Sayı

Makale detayları

Yazarlar: Dilek Çağlayan | Ramazan Dertli | Melek Çağlayan | Mahmut Selman Yıldırım | Hüseyin Ataseven

Yayıncı: Selcuk University

Ana Başlıklar: Gastroenteroloji ve Hepatoloji

Dergi: Genel Tıp Dergisi Vol.34 Issue 5, pp.603-608

Belge Tipi: Makale

Yayın Tarihi: 10/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001330462

pISSN: 2602-3741

Sayı

Yazarlar:

Dilek Çağlayan | Ramazan Dertli | Melek Çağlayan | Mahmut Selman Yıldırım | Hüseyin Ataseven

Yayıncı:

Selcuk University

Ana Başlıklar:

Gastroenteroloji ve Hepatoloji

Dergi:

Genel Tıp Dergisi Vol.34 Issue 5, pp.603-608

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330462

pISSN:

2602-3741