The effects of Origanum onites in streptozotocin-induced diabetes mellitus in rats

Elif Beyzanur Polat; Turgut Taşkın; Leyla Bitiş; Kübra Elçioğlu

Makale detayları

The effects of Origanum onites in streptozotocin-induced diabetes mellitus in rats

Yazarlar:

Elif Beyzanur Polat | Turgut Taşkın | Leyla Bitiş | Kübra Elçioğlu

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy | Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 6, pp.1884-1892

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347798

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Diabetes mellitus is a chronic disease characterized by decreased insulin synthesis andor increased blood glucose due to insulin resistance. In this study, streptozotocin STZ-induced diabetic rats were evaluated and it was aimed to investigate the protective effects of Origanum onites L. OO against possible changes in these parameters. Male Sprague-Dawley rats weighing 300-400g were divided into three groups control C, diabetes mellitus DM and diabetes mellitus  OO OO group. DM was induced by administration of STZ 60 mgkg dose intraperitoneally i.p. after 48 hours, rats with blood glucose values higher than 200 mgdL were considered DM. Origanum extract was administered i.p. to the OO group at 50 mgkg per day for 6 weeks. Serum AST, ALT, creatinine, and inflammatory cytokine levels were measured. MDA and GSH levels were measured in liver tissues. AST, ALT, creatinine, and MDA levels were found to be increased in the DM group, while a significant decrease in these levels was observed in the treated group. While GSH values fell in the DM group, a significant increase occurred in the OO group n6, p0.0001; two-way ANOVA. When the plasma levels of cytokines were examined, an increase was observed in the DM group and a significant decrease was observed in the OO group. When we evaluate our findings, we think that OO has a protective effect against complications that may occur in DM by preventing oxidant damage and inflammation. Further studies are needed on the protective effects of OO in DM.

 Diabetes mellitus is a chronic disease characterized by decreased insulin synthesis andor increased blood glucose due to insulin resistance. In this study, streptozotocin STZ-induced diabetic rats were evaluated and it was aimed to investigate the protective effects of Origanum onites L. OO against possible changes in these parameters. Male Sprague-Dawley rats weighing 300-400g were divided into three groups control C, diabetes mellitus DM and diabetes mellitus  OO OO group. DM was induced by administration of STZ 60 mgkg dose intraperitoneally i.p. after 48 hours, rats with blood glucose values higher than 200 mgdL were considered DM. Origanum extract was administered i.p. to the OO group at 50 mgkg per day for 6 weeks. Serum AST, ALT, creatinine, and inflammatory cytokine levels were measured. MDA and GSH levels were measured in liver tissues. AST, ALT, creatinine, and MDA levels were found to be increased in the DM group, while a significant decrease in these levels was observed in the treated group. While GSH values fell in the DM group, a significant increase occurred in the OO group n6, p0.0001; two-way ANOVA. When the plasma levels of cytokines were examined, an increase was observed in the DM group and a significant decrease was observed in the OO group. When we evaluate our findings, we think that OO has a protective effect against complications that may occur in DM by preventing oxidant damage and inflammation. Further studies are needed on the protective effects of OO in DM.

 Diabetes mellitus is a chronic disease characterized by decreased insulin synthesis andor increased blood glucose due to insulin resistance. In this study, streptozotocin STZ-induced diabetic rats were evaluated and it was aimed to investigate the protective effects of Origanum onites L. OO against possible changes in these parameters. Male Sprague-Dawley rats weighing 300-400g were divided into three groups control C, diabetes mellitus DM and diabetes mellitus  OO OO group. DM was induced by administration of STZ 60 mgkg dose intraperitoneally i.p. after 48 hours, rats with blood glucose values higher than 200 mgdL were considered DM. Origanum extract was administered i.p. to the OO group at 50 mgkg per day for 6 weeks. Serum AST, ALT, creatinine, and inflammatory cytokine levels were measured. MDA and GSH levels were measured in liver tissues. AST, ALT, creatinine, and MDA levels were found to be increased in the DM group, while a significant decrease in these levels was observed in the treated group. While GSH values fell in the DM group, a significant increase occurred in the OO group n6, p0.0001; two-way ANOVA. When the plasma levels of cytokines were examined, an increase was observed in the DM group and a significant decrease was observed in the OO group. When we evaluate our findings, we think that OO has a protective effect against complications that may occur in DM by preventing oxidant damage and inflammation. Further studies are needed on the protective effects of OO in DM.

 Diabetes mellitus is a chronic disease characterized by decreased insulin synthesis andor increased blood glucose due to insulin resistance. In this study, streptozotocin STZ-induced diabetic rats were evaluated and it was aimed to investigate the protective effects of Origanum onites L. OO against possible changes in these parameters. Male Sprague-Dawley rats weighing 300-400g were divided into three groups control C, diabetes mellitus DM and diabetes mellitus  OO OO group. DM was induced by administration of STZ 60 mgkg dose intraperitoneally i.p. after 48 hours, rats with blood glucose values higher than 200 mgdL were considered DM. Origanum extract was administered i.p. to the OO group at 50 mgkg per day for 6 weeks. Serum AST, ALT, creatinine, and inflammatory cytokine levels were measured. MDA and GSH levels were measured in liver tissues. AST, ALT, creatinine, and MDA levels were found to be increased in the DM group, while a significant decrease in these levels was observed in the treated group. While GSH values fell in the DM group, a significant increase occurred in the OO group n6, p0.0001; two-way ANOVA. When the plasma levels of cytokines were examined, an increase was observed in the DM group and a significant decrease was observed in the OO group. When we evaluate our findings, we think that OO has a protective effect against complications that may occur in DM by preventing oxidant damage and inflammation. Further studies are needed on the protective effects of OO in DM.

Makale detayları

The effects of Origanum onites in streptozotocin-induced diabetes mellitus in rats

Yazarlar:

Elif Beyzanur Polat | Turgut Taşkın | Leyla Bitiş | Kübra Elçioğlu

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy | Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 6, pp.1884-1892

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347798

pISSN:

2630-6344

Diabetes mellitus

oxidative stress

liver

Origanum onites

inflammatory cytokine

Sayı

Makale detayları

The effects of Origanum onites in streptozotocin-induced diabetes mellitus in rats

Yazarlar: Elif Beyzanur Polat | Turgut Taşkın | Leyla Bitiş | Kübra Elçioğlu

Yayıncı: Marmara University

Ana Başlıklar: Pharmacognosy | Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.26 Issue 6, pp.1884-1892

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347798

pISSN: 2630-6344

Diabetes mellitus

oxidative stress

liver

Origanum onites

inflammatory cytokine

Sayı

Yazarlar:

Elif Beyzanur Polat | Turgut Taşkın | Leyla Bitiş | Kübra Elçioğlu

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy | Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 6, pp.1884-1892

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347798

pISSN:

2630-6344