Evaluation of Kidney Functions in Patients with Cirrhosis

Ahmet Uyanıkoğlu; Süleyman Sari

Makale detayları

Evaluation of Kidney Functions in Patients with Cirrhosis

Yazarlar:

Ahmet Uyanıkoğlu | Süleyman Sari

Yayıncı:

Istanbul Aydin University

Ana Başlıklar:

Gastroenteroloji ve Hepatoloji

Dergi:

Tıp Fakültesi Klinikleri Dergisi Vol.8 Issue 1, pp.31-35

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342668

pISSN:

2630-5585

Anahtar kelimeler:

Özet:

 Introduction: Renal functions are frequently impaired in patients with cirrhosis. In this study, it was aimed to evaluate kidney functions in patients with cirrhosis. Materials and Methods: The cross-sectional study were included 321 cirrhosis patients. Imaging, laboratory, and clinical approaches were used to diagnose cirrhosis. The Modification of Diet in Renal Diseases Study MDRD formula, which is based on serum creatinine, was used to calculate glomerular filtration rate GFR. Results: Of 321 cirrhotic patients, 189 58 were male, mean age was 55.6  15.1 years, age range was 18-91 years. While 116 36 of the patients were compensated, 205 64 were decompensated. Etiological causes of cirrhosis 134 42 hepatitis B, 98 30 cryptogenic, 46 14 hepatitis C, 10 Wilson 3, 10 delta hepatitis 3, 23 8 other causes alcoholic cirrhosis, cardiogenic cirrhosis, Budd-Chiari, biliary cirrhosis etc.. The mean GFR of the patients was 96.2  27.8 mlmin. While GFR was within the normal range in 205 patients 63, it was below the normal range in 118 37 patients. Of the patients with low GFR, 87 73 were at stage 1, 23 20 were at stage 2, 6 5 were at stage 3 and 2 2 were at the limit of end-stage renal disease. Conclusion: The most common etiological cause in our region in patients with cirrhosis is hepatitis B, cryptogenic in the second place and hepatitis C in the third place. Nearly two-thirds of the patients had decompensated cirrhosis, and at least one-third of all cirrhotic patients had kidney injury.

 Introduction: Renal functions are frequently impaired in patients with cirrhosis. In this study, it was aimed to evaluate kidney functions in patients with cirrhosis. Materials and Methods: The cross-sectional study were included 321 cirrhosis patients. Imaging, laboratory, and clinical approaches were used to diagnose cirrhosis. The Modification of Diet in Renal Diseases Study MDRD formula, which is based on serum creatinine, was used to calculate glomerular filtration rate GFR. Results: Of 321 cirrhotic patients, 189 58 were male, mean age was 55.6  15.1 years, age range was 18-91 years. While 116 36 of the patients were compensated, 205 64 were decompensated. Etiological causes of cirrhosis 134 42 hepatitis B, 98 30 cryptogenic, 46 14 hepatitis C, 10 Wilson 3, 10 delta hepatitis 3, 23 8 other causes alcoholic cirrhosis, cardiogenic cirrhosis, Budd-Chiari, biliary cirrhosis etc.. The mean GFR of the patients was 96.2  27.8 mlmin. While GFR was within the normal range in 205 patients 63, it was below the normal range in 118 37 patients. Of the patients with low GFR, 87 73 were at stage 1, 23 20 were at stage 2, 6 5 were at stage 3 and 2 2 were at the limit of end-stage renal disease. Conclusion: The most common etiological cause in our region in patients with cirrhosis is hepatitis B, cryptogenic in the second place and hepatitis C in the third place. Nearly two-thirds of the patients had decompensated cirrhosis, and at least one-third of all cirrhotic patients had kidney injury.

 Introduction: Renal functions are frequently impaired in patients with cirrhosis. In this study, it was aimed to evaluate kidney functions in patients with cirrhosis. Materials and Methods: The cross-sectional study were included 321 cirrhosis patients. Imaging, laboratory, and clinical approaches were used to diagnose cirrhosis. The Modification of Diet in Renal Diseases Study MDRD formula, which is based on serum creatinine, was used to calculate glomerular filtration rate GFR. Results: Of 321 cirrhotic patients, 189 58 were male, mean age was 55.6  15.1 years, age range was 18-91 years. While 116 36 of the patients were compensated, 205 64 were decompensated. Etiological causes of cirrhosis 134 42 hepatitis B, 98 30 cryptogenic, 46 14 hepatitis C, 10 Wilson 3, 10 delta hepatitis 3, 23 8 other causes alcoholic cirrhosis, cardiogenic cirrhosis, Budd-Chiari, biliary cirrhosis etc.. The mean GFR of the patients was 96.2  27.8 mlmin. While GFR was within the normal range in 205 patients 63, it was below the normal range in 118 37 patients. Of the patients with low GFR, 87 73 were at stage 1, 23 20 were at stage 2, 6 5 were at stage 3 and 2 2 were at the limit of end-stage renal disease. Conclusion: The most common etiological cause in our region in patients with cirrhosis is hepatitis B, cryptogenic in the second place and hepatitis C in the third place. Nearly two-thirds of the patients had decompensated cirrhosis, and at least one-third of all cirrhotic patients had kidney injury.

 Amaç: Siroz hastalarında böbrek fonksiyonları sıklıkla bozulmaktadır. Bu çalışmada sirozlu hastalarda böbrek fonksiyonlarının değerlendirilmesi amaçlanmıştır. Materyal - Metod: Çalışmaya kesitsel olarak sirozu olan 321 hasta alınmıştır. Siroz tanısı klinik, laboratuvar ve görüntüleme yöntemleri ile konulmuştur. Glomerüler filtrasyon hızı GFR serum kreatinin temelli Modification of Diet in Renal Disaeses Study MDRD formülüyle hesaplanmıştır. Bulgular: Sirotik 321 hastanın, 189u erkek 58, yaş ortalaması 55.6  15.1, yaş dağılımı 18-91 yaş idi. Hastaların 116sı 36 kompanse iken, 205i 64 dekompanse idi. Sirozun etyolojik nedenleri 134 42 hepatit B, 98 30 kriptojenik, 46 14 hepatit C, 10 Wilson 3, 10 delta hepatiti 3, 23 8 diğer nedenler alkolik siroz, kardiyojenik siroz, Budd-Chiari, biliyer siroz vs idi. Hastaların ortalama GFRsi 96.2  27.8 mldk idi. GFR 205 hastada 63 normal sınırlarda iken, 118 hastada 37 normal sınırın altındaydı. GFR düşük olan hastalardan 87si 73 evre 1, 23ü20 evre 2, 6sı 5 evre 3 ve 2si 2 son dönem böbrek yetmezliği sınırında idi. Sonuç: Sirozlu hastalarda bölgemizde en sık etyolojik neden hepatit B, ikinci sırada kriptojenik, üçüncü sırada hepatit Cdir. Hastaların üçte ikiye yakını dekompanse siroz olup, tüm sirotik hastaların en az üçte birinde böbrek hasarı vardı.

Makale detayları

Evaluation of Kidney Functions in Patients with Cirrhosis

Yazarlar:

Ahmet Uyanıkoğlu | Süleyman Sari

Yayıncı:

Istanbul Aydin University

Ana Başlıklar:

Gastroenteroloji ve Hepatoloji

Dergi:

Tıp Fakültesi Klinikleri Dergisi Vol.8 Issue 1, pp.31-35

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342668

pISSN:

2630-5585

cirrhosis

kidney injury

glomerular filtration ratesiroz

böbrek hasarı

glomerüler filtrasyon hızı

Sayı

Makale detayları

Evaluation of Kidney Functions in Patients with Cirrhosis

Yazarlar: Ahmet Uyanıkoğlu | Süleyman Sari

Yayıncı: Istanbul Aydin University

Ana Başlıklar: Gastroenteroloji ve Hepatoloji

Dergi: Tıp Fakültesi Klinikleri Dergisi Vol.8 Issue 1, pp.31-35

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001342668

pISSN: 2630-5585

cirrhosis

kidney injury

glomerular filtration ratesiroz

böbrek hasarı

glomerüler filtrasyon hızı

Sayı

Yazarlar:

Ahmet Uyanıkoğlu | Süleyman Sari

Yayıncı:

Istanbul Aydin University

Ana Başlıklar:

Gastroenteroloji ve Hepatoloji

Dergi:

Tıp Fakültesi Klinikleri Dergisi Vol.8 Issue 1, pp.31-35

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342668

pISSN:

2630-5585