Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application

Seda Rençber; Neslihan Üstündağ; Zeynep Senyiğit

Makale detayları

Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application

Yazarlar:

Seda Rençber | Neslihan Üstündağ | Zeynep Senyiğit

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 1, pp.1-12

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346148

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 This study aimed to assess the potential usage of fusidic acid in situ ocular gels for bacterial conjunctivitis treatment. The in situ gelling systems were applied to improve the bioavailability and residence time of fusidic acid in the ocular mucosa. Temperature-triggered in situ ocular gel formulations were prepared by the cold method with Poloxamer 407 and sodium carboxymethyl cellulose. The in situ gels were evaluated for pH, clarity, gelation temperature, rheological properties, mechanical properties, and in vitro drug release. The gelation temperatures of fusidic acid loaded the formulations were between 2933C. All prepared in situ gels showed non- Newtonian pseudoplastic flow shear thinning system like tear fluid at 32  0.1ºC. The results of in vitro dissolution studies showed that at least 65 of fusidic acid released in 12 hours. As a result of this study, it was concluded that fusidic acid loaded in situ gels might be offered as a promising ocular tool for the treatment of bacterial conjunctivitis.

 This study aimed to assess the potential usage of fusidic acid in situ ocular gels for bacterial conjunctivitis treatment. The in situ gelling systems were applied to improve the bioavailability and residence time of fusidic acid in the ocular mucosa. Temperature-triggered in situ ocular gel formulations were prepared by the cold method with Poloxamer 407 and sodium carboxymethyl cellulose. The in situ gels were evaluated for pH, clarity, gelation temperature, rheological properties, mechanical properties, and in vitro drug release. The gelation temperatures of fusidic acid loaded the formulations were between 2933C. All prepared in situ gels showed non- Newtonian pseudoplastic flow shear thinning system like tear fluid at 32  0.1ºC. The results of in vitro dissolution studies showed that at least 65 of fusidic acid released in 12 hours. As a result of this study, it was concluded that fusidic acid loaded in situ gels might be offered as a promising ocular tool for the treatment of bacterial conjunctivitis.

 This study aimed to assess the potential usage of fusidic acid in situ ocular gels for bacterial conjunctivitis treatment. The in situ gelling systems were applied to improve the bioavailability and residence time of fusidic acid in the ocular mucosa. Temperature-triggered in situ ocular gel formulations were prepared by the cold method with Poloxamer 407 and sodium carboxymethyl cellulose. The in situ gels were evaluated for pH, clarity, gelation temperature, rheological properties, mechanical properties, and in vitro drug release. The gelation temperatures of fusidic acid loaded the formulations were between 2933C. All prepared in situ gels showed non- Newtonian pseudoplastic flow shear thinning system like tear fluid at 32  0.1ºC. The results of in vitro dissolution studies showed that at least 65 of fusidic acid released in 12 hours. As a result of this study, it was concluded that fusidic acid loaded in situ gels might be offered as a promising ocular tool for the treatment of bacterial conjunctivitis.

 This study aimed to assess the potential usage of fusidic acid in situ ocular gels for bacterial conjunctivitis treatment. The in situ gelling systems were applied to improve the bioavailability and residence time of fusidic acid in the ocular mucosa. Temperature-triggered in situ ocular gel formulations were prepared by the cold method with Poloxamer 407 and sodium carboxymethyl cellulose. The in situ gels were evaluated for pH, clarity, gelation temperature, rheological properties, mechanical properties, and in vitro drug release. The gelation temperatures of fusidic acid loaded the formulations were between 2933C. All prepared in situ gels showed non- Newtonian pseudoplastic flow shear thinning system like tear fluid at 32  0.1ºC. The results of in vitro dissolution studies showed that at least 65 of fusidic acid released in 12 hours. As a result of this study, it was concluded that fusidic acid loaded in situ gels might be offered as a promising ocular tool for the treatment of bacterial conjunctivitis.

Makale detayları

Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application

Yazarlar:

Seda Rençber | Neslihan Üstündağ | Zeynep Senyiğit

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 1, pp.1-12

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346148

pISSN:

2630-6344

Fusidic acid

in situ gel

poloxamer

NaCMC

ocular

Sayı

Makale detayları

Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application

Yazarlar: Seda Rençber | Neslihan Üstündağ | Zeynep Senyiğit

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Delivery Technologies

Dergi: Journal of Research in Pharmacy Vol.25 Issue 1, pp.1-12

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346148

pISSN: 2630-6344

Fusidic acid

in situ gel

poloxamer

NaCMC

ocular

Sayı

Yazarlar:

Seda Rençber | Neslihan Üstündağ | Zeynep Senyiğit

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 1, pp.1-12

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346148

pISSN:

2630-6344