Effects of short-term hyperglycemia on the vasoconstriction of the aorta

Soner DÖNMEZ; Osman GÖKALP; Mustafa DOĞAN; Hüseyin VURAL; Barbaros YİĞİT

Makale detayları

Effects of short-term hyperglycemia on the vasoconstriction of the aorta

Yazarlar:

Soner DÖNMEZ | Osman GÖKALP | Mustafa DOĞAN | Hüseyin VURAL | Barbaros YİĞİT

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 6, pp.941-945

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000752952

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

To investigate vasoconstrictor responses of healthy blood vessels to short-term hyperglycemic conditions such as postprandial hyperglycemia, gestational diabetes mellitus, and steroid-induced diabetes.  Materials and methods: Female Wistar rat aorta rings were incubated in normal (11 mM) and high (22 mM and 44 mM) glucose concentrations for 4 h. Responses of vasoconstriction were measured in reaction to serotonin (10-5 M), phenylephrine (10-6 M), and KCl (60 mM) compared to the ambient condition, including different glucose concentrations.  Results: While the responses of vasoconstriction to KCl were increased in the presence of Krebs' solution with high glucose, no statistically significant changes were observed in the reaction to serotonin and phenylephrine. In addition, malondialdehyde levels were increased in hyperglycemic conditions.   Conclusion: Short-term hyperglycemia may lead to augmented contractile response in aorta rings through several mechanisms, and our results showed that oxidative stress is probably one of them.

 

To investigate vasoconstrictor responses of healthy blood vessels to short-term hyperglycemic conditions such as postprandial hyperglycemia, gestational diabetes mellitus, and steroid-induced diabetes.  Materials and methods: Female Wistar rat aorta rings were incubated in normal (11 mM) and high (22 mM and 44 mM) glucose concentrations for 4 h. Responses of vasoconstriction were measured in reaction to serotonin (10-5 M), phenylephrine (10-6 M), and KCl (60 mM) compared to the ambient condition, including different glucose concentrations.  Results: While the responses of vasoconstriction to KCl were increased in the presence of Krebs' solution with high glucose, no statistically significant changes were observed in the reaction to serotonin and phenylephrine. In addition, malondialdehyde levels were increased in hyperglycemic conditions.   Conclusion: Short-term hyperglycemia may lead to augmented contractile response in aorta rings through several mechanisms, and our results showed that oxidative stress is probably one of them.

Makale detayları

Effects of short-term hyperglycemia on the vasoconstriction of the aorta

Yazarlar: Soner DÖNMEZ | Osman GÖKALP | Mustafa DOĞAN | Hüseyin VURAL | Barbaros YİĞİT

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2014 Vol.44 Issue 6, pp.941-945

Belge Tipi: Makale

Yayın Tarihi: 5/2014

Belge Dili: Türkçe

Document ID (Org No.): 2000752952

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Short-term hyperglycemia

vasoconstriction

oxidative stress

Sayı

Yazarlar:

Soner DÖNMEZ | Osman GÖKALP | Mustafa DOĞAN | Hüseyin VURAL | Barbaros YİĞİT

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 6, pp.941-945

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000752952

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144