Comparison of Serum and Salivary CRP Levels with Leukocyte Parameters in Dogs with Canine Parvoviral Enteritis

Erdem Gülersoy

Makale detayları

Comparison of Serum and Salivary CRP Levels with Leukocyte Parameters in Dogs with Canine Parvoviral Enteritis

Yazarlar:

Erdem Gülersoy

Yayıncı:

Kastamonu University

Ana Başlıklar:

Veterinary Sciences (Other)

Dergi:

Veterinary Journal of Kastamonu University Vol.4 Issue 1, pp.14-24

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001353766

pISSN:

2822-4922

Anahtar kelimeler:

Özet:

 Aim to study: Canine parvovirus CPV is a highly contagious cause of enteritis, associated with high morbidity, mortality, and low survival rates in untreated dogs. While severe disease primarily affects younger dogs, immunocompromised adults may also be susceptible. Since the clinical signs of CPV infection are nonspecific, reliable biomarkers are essential for differential diagnosis and disease severity assessment. This study aimed to evaluate the correlation between serum and salivary C-reactive protein CRP levels in dogs with parvoviral enteritis PVE and their association with complete blood count CBC parameters. Additionally, we sought to highlight the clinical relevance of saliva as an alternative diagnostic fluid, reducing the need for frequent blood sampling and minimizing stress in affected animals. Material and methods: A total of 20 dogs 10 healthy controls, 10 with PVE underwent physical and laboratory examinations, including CBC and serum and salivary CRP measurements. Results: In the PVE group, WBC, monocyte, granulocyte, MCH, and MCHC levels were significantly lower P  0.020, whereas serum and salivary CRP levels were markedly elevated P  0.000. ROC analysis demonstrated the outstanding diagnostic performance of serum and salivary CRP levels AUC  0.900. Moreover, a very strong positive correlation was observed between serum and salivary CRP concentrations r  0.912. Conclusion: These findings suggest that salivary CRP, like serum CRP, may serve as a valuable biomarker for assessing disease severity in CPV cases where blood collection is challenging. However, further studies are needed to confirm its diagnostic and prognostic reliability, considering factors such as dilution and salivary flow rate.

 Aim to study: Canine parvovirus CPV is a highly contagious cause of enteritis, associated with high morbidity, mortality, and low survival rates in untreated dogs. While severe disease primarily affects younger dogs, immunocompromised adults may also be susceptible. Since the clinical signs of CPV infection are nonspecific, reliable biomarkers are essential for differential diagnosis and disease severity assessment. This study aimed to evaluate the correlation between serum and salivary C-reactive protein CRP levels in dogs with parvoviral enteritis PVE and their association with complete blood count CBC parameters. Additionally, we sought to highlight the clinical relevance of saliva as an alternative diagnostic fluid, reducing the need for frequent blood sampling and minimizing stress in affected animals. Material and methods: A total of 20 dogs 10 healthy controls, 10 with PVE underwent physical and laboratory examinations, including CBC and serum and salivary CRP measurements. Results: In the PVE group, WBC, monocyte, granulocyte, MCH, and MCHC levels were significantly lower P  0.020, whereas serum and salivary CRP levels were markedly elevated P  0.000. ROC analysis demonstrated the outstanding diagnostic performance of serum and salivary CRP levels AUC  0.900. Moreover, a very strong positive correlation was observed between serum and salivary CRP concentrations r  0.912. Conclusion: These findings suggest that salivary CRP, like serum CRP, may serve as a valuable biomarker for assessing disease severity in CPV cases where blood collection is challenging. However, further studies are needed to confirm its diagnostic and prognostic reliability, considering factors such as dilution and salivary flow rate.

 Aim to study: Canine parvovirus CPV is a highly contagious cause of enteritis, associated with high morbidity, mortality, and low survival rates in untreated dogs. While severe disease primarily affects younger dogs, immunocompromised adults may also be susceptible. Since the clinical signs of CPV infection are nonspecific, reliable biomarkers are essential for differential diagnosis and disease severity assessment. This study aimed to evaluate the correlation between serum and salivary C-reactive protein CRP levels in dogs with parvoviral enteritis PVE and their association with complete blood count CBC parameters. Additionally, we sought to highlight the clinical relevance of saliva as an alternative diagnostic fluid, reducing the need for frequent blood sampling and minimizing stress in affected animals. Material and methods: A total of 20 dogs 10 healthy controls, 10 with PVE underwent physical and laboratory examinations, including CBC and serum and salivary CRP measurements. Results: In the PVE group, WBC, monocyte, granulocyte, MCH, and MCHC levels were significantly lower P  0.020, whereas serum and salivary CRP levels were markedly elevated P  0.000. ROC analysis demonstrated the outstanding diagnostic performance of serum and salivary CRP levels AUC  0.900. Moreover, a very strong positive correlation was observed between serum and salivary CRP concentrations r  0.912. Conclusion: These findings suggest that salivary CRP, like serum CRP, may serve as a valuable biomarker for assessing disease severity in CPV cases where blood collection is challenging. However, further studies are needed to confirm its diagnostic and prognostic reliability, considering factors such as dilution and salivary flow rate.

 Aim to study: Canine parvovirus CPV is a highly contagious cause of enteritis, associated with high morbidity, mortality, and low survival rates in untreated dogs. While severe disease primarily affects younger dogs, immunocompromised adults may also be susceptible. Since the clinical signs of CPV infection are nonspecific, reliable biomarkers are essential for differential diagnosis and disease severity assessment. This study aimed to evaluate the correlation between serum and salivary C-reactive protein CRP levels in dogs with parvoviral enteritis PVE and their association with complete blood count CBC parameters. Additionally, we sought to highlight the clinical relevance of saliva as an alternative diagnostic fluid, reducing the need for frequent blood sampling and minimizing stress in affected animals. Material and methods: A total of 20 dogs 10 healthy controls, 10 with PVE underwent physical and laboratory examinations, including CBC and serum and salivary CRP measurements. Results: In the PVE group, WBC, monocyte, granulocyte, MCH, and MCHC levels were significantly lower P  0.020, whereas serum and salivary CRP levels were markedly elevated P  0.000. ROC analysis demonstrated the outstanding diagnostic performance of serum and salivary CRP levels AUC  0.900. Moreover, a very strong positive correlation was observed between serum and salivary CRP concentrations r  0.912. Conclusion: These findings suggest that salivary CRP, like serum CRP, may serve as a valuable biomarker for assessing disease severity in CPV cases where blood collection is challenging. However, further studies are needed to confirm its diagnostic and prognostic reliability, considering factors such as dilution and salivary flow rate.

Makale detayları

Comparison of Serum and Salivary CRP Levels with Leukocyte Parameters in Dogs with Canine Parvoviral Enteritis

Yazarlar: Erdem Gülersoy

Yayıncı: Kastamonu University

Ana Başlıklar: Veterinary Sciences (Other)

Dergi: Veterinary Journal of Kastamonu University Vol.4 Issue 1, pp.14-24

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001353766

pISSN: 2822-4922

biomarker

CRP

dog

saliva

serum

Sayı

Yazarlar:

Erdem Gülersoy

Yayıncı:

Kastamonu University

Ana Başlıklar:

Veterinary Sciences (Other)

Dergi:

Veterinary Journal of Kastamonu University Vol.4 Issue 1, pp.14-24

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001353766

pISSN:

2822-4922