Anticancer and antituberculosis effects of 5-fluoro- 1H-indole-2,3-dione 3-thiosemicarbazones

Zekiye Şeyma SEVİNÇLİ; Zerrin CANTÜRK; Miriş DİKMEN; Nilgün KARALI

Makale detayları

Anticancer and antituberculosis effects of 5-fluoro- 1H-indole-2,3-dione 3-thiosemicarbazones

Yazarlar:

Zekiye Şeyma SEVİNÇLİ | Zerrin CANTÜRK | Miriş DİKMEN | Nilgün KARALI

Yayıncı:

Istanbul University

Ana Başlıklar:

Farmakoloji ve terapötik | Sağlık teşvikleri

Dergi:

İstanbul Journal of Pharmacy 2020 Vol.50 Issue 3, pp.176-180

Belge Tipi:

Makale

Yayın Tarihi:

12/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000512911

Sıklık:

Aylık

eISSN:

2587-2087

Özet:

 

Background and Aims: The aim of this study was to screen the in vitro anticancer/antituberculosis activities of 5-fluoro- 1-methyl/ethyl-1H-indole-2,3-dione 3-thiosemicarbazones. Methods: A549/U-87MG cell lines were used for the anticancer activity of the compounds, while CCD-19Lu cell line was used to determine their cytotoxic effects. In antituberculosis activity studies using MTB H37Rv cell line, BJ cell line was used to determine the cytotoxic effects. MTT assay was used to obtain IC50 values. Results: 6a, 6b, 6g, 6h, 6l, 6n, 7c, 7k and 7l were found to be highly effective against A549 cell line compared to cisplatin whereas 6d, 6h, 6l, 6n, 7d and 7f were found to be effective against U-87MG cell line compared to cisplatin. It was also determined that 6a, 6b and 7l did not show cytotoxic effects on CCD-19Lu cell line. The antituberculosis effects of the compounds were investigated against MTB H37Rv cell groups using rifampicin as standard. It was determined that 6b, 6c, 6g-k, 6n, 7b, 7j and 7l have near-standard activity and 6b, 7b and 7l were not cytotoxic on BJ cell line. Conclusion: While determining effective compounds in anticancer studies, it was concluded that active compounds can be reached by modifications in compounds in antituberculosis studies.

Makale detayları

Anticancer and antituberculosis effects of 5-fluoro- 1H-indole-2,3-dione 3-thiosemicarbazones

Yazarlar: Zekiye Şeyma SEVİNÇLİ | Zerrin CANTÜRK | Miriş DİKMEN | Nilgün KARALI

Yayıncı: Istanbul University

Ana Başlıklar: Farmakoloji ve terapötik | Sağlık teşvikleri

Dergi: İstanbul Journal of Pharmacy 2020 Vol.50 Issue 3, pp.176-180

Belge Tipi: Makale

Yayın Tarihi: 12/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000512911

Sıklık: Aylık

eISSN: 2587-2087

Sayı

Yazarlar:

Zekiye Şeyma SEVİNÇLİ | Zerrin CANTÜRK | Miriş DİKMEN | Nilgün KARALI

Yayıncı:

Istanbul University

Ana Başlıklar:

Farmakoloji ve terapötik | Sağlık teşvikleri

Dergi:

İstanbul Journal of Pharmacy 2020 Vol.50 Issue 3, pp.176-180

Belge Tipi:

Makale

Yayın Tarihi:

12/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000512911

Sıklık:

Aylık

eISSN:

2587-2087