Biological activities assessment of secondary metabolites derived from Aspergillus species

N.A.

Makale detayları

Biological activities assessment of secondary metabolites derived from Aspergillus species

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 4, pp.1562-1572

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342456

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Aspergillus species are valuable sources of bioactive compounds with potential therapeutic, industrial, and agri-food applications. Therefore, the aim of this study was to evaluate different biological activities including; antioxidant, anti-inflammatory, antidiabetic, antifungal, and antiproliferative exhibited by secondary metabolites produced by three fungal species; Aspergillus quadrilineatus MH109538, Aspergillus niveus MH109544 and Aspergillus wentii MH109545. The obtained results showed that the Aspergillus wentii extract exhibited significant activity in the DPPH and Phenanthroline assays, with an IC50 values of 131.85  0.72 μgmL, and an ABS0-5 value of 55.58  1.08 μgmL respectively. While Aspergillus niveus extract demonstrated considerable antioxidant activity in the ABTS test, with an IC50 value of 78.15  1.41 μgmL. In addition, the assessment of anti-inflammatory activity revealed a significant effect of the Aspergillus quadrilineatus extract, with an IC50 value of 280.00  0.43 μgmL. Furthermore, the three extracts exhibited significant anti-diabetic activity compared to the reference molecule acarbose. Regarding antifungal activity, evaluated by well method against three fungal strains, the Aspergillus niveus extract showed an important effect against the yeast Candida albicans with an inhibition zone diameter of 24.6 mm. Moreover, the MTS assay indicated cytotoxicity of the three fungal strains against the used cell lines recording 100  mortality for Aspergillus quadrilineatus at 0.5 mgmL and 0.25 mgmL concentrations, and for Aspergillus niveus and Aspergillus wentii at 0.5 mgmL against the MCF-7 tumor cell line.

 Aspergillus species are valuable sources of bioactive compounds with potential therapeutic, industrial, and agri-food applications. Therefore, the aim of this study was to evaluate different biological activities including; antioxidant, anti-inflammatory, antidiabetic, antifungal, and antiproliferative exhibited by secondary metabolites produced by three fungal species; Aspergillus quadrilineatus MH109538, Aspergillus niveus MH109544 and Aspergillus wentii MH109545. The obtained results showed that the Aspergillus wentii extract exhibited significant activity in the DPPH and Phenanthroline assays, with an IC50 values of 131.85  0.72 μgmL, and an ABS0-5 value of 55.58  1.08 μgmL respectively. While Aspergillus niveus extract demonstrated considerable antioxidant activity in the ABTS test, with an IC50 value of 78.15  1.41 μgmL. In addition, the assessment of anti-inflammatory activity revealed a significant effect of the Aspergillus quadrilineatus extract, with an IC50 value of 280.00  0.43 μgmL. Furthermore, the three extracts exhibited significant anti-diabetic activity compared to the reference molecule acarbose. Regarding antifungal activity, evaluated by well method against three fungal strains, the Aspergillus niveus extract showed an important effect against the yeast Candida albicans with an inhibition zone diameter of 24.6 mm. Moreover, the MTS assay indicated cytotoxicity of the three fungal strains against the used cell lines recording 100  mortality for Aspergillus quadrilineatus at 0.5 mgmL and 0.25 mgmL concentrations, and for Aspergillus niveus and Aspergillus wentii at 0.5 mgmL against the MCF-7 tumor cell line.

 Aspergillus species are valuable sources of bioactive compounds with potential therapeutic, industrial, and agri-food applications. Therefore, the aim of this study was to evaluate different biological activities including; antioxidant, anti-inflammatory, antidiabetic, antifungal, and antiproliferative exhibited by secondary metabolites produced by three fungal species; Aspergillus quadrilineatus MH109538, Aspergillus niveus MH109544 and Aspergillus wentii MH109545. The obtained results showed that the Aspergillus wentii extract exhibited significant activity in the DPPH and Phenanthroline assays, with an IC50 values of 131.85  0.72 μgmL, and an ABS0-5 value of 55.58  1.08 μgmL respectively. While Aspergillus niveus extract demonstrated considerable antioxidant activity in the ABTS test, with an IC50 value of 78.15  1.41 μgmL. In addition, the assessment of anti-inflammatory activity revealed a significant effect of the Aspergillus quadrilineatus extract, with an IC50 value of 280.00  0.43 μgmL. Furthermore, the three extracts exhibited significant anti-diabetic activity compared to the reference molecule acarbose. Regarding antifungal activity, evaluated by well method against three fungal strains, the Aspergillus niveus extract showed an important effect against the yeast Candida albicans with an inhibition zone diameter of 24.6 mm. Moreover, the MTS assay indicated cytotoxicity of the three fungal strains against the used cell lines recording 100  mortality for Aspergillus quadrilineatus at 0.5 mgmL and 0.25 mgmL concentrations, and for Aspergillus niveus and Aspergillus wentii at 0.5 mgmL against the MCF-7 tumor cell line.

 Aspergillus species are valuable sources of bioactive compounds with potential therapeutic, industrial, and agri-food applications. Therefore, the aim of this study was to evaluate different biological activities including; antioxidant, anti-inflammatory, antidiabetic, antifungal, and antiproliferative exhibited by secondary metabolites produced by three fungal species; Aspergillus quadrilineatus MH109538, Aspergillus niveus MH109544 and Aspergillus wentii MH109545. The obtained results showed that the Aspergillus wentii extract exhibited significant activity in the DPPH and Phenanthroline assays, with an IC50 values of 131.85  0.72 μgmL, and an ABS0-5 value of 55.58  1.08 μgmL respectively. While Aspergillus niveus extract demonstrated considerable antioxidant activity in the ABTS test, with an IC50 value of 78.15  1.41 μgmL. In addition, the assessment of anti-inflammatory activity revealed a significant effect of the Aspergillus quadrilineatus extract, with an IC50 value of 280.00  0.43 μgmL. Furthermore, the three extracts exhibited significant anti-diabetic activity compared to the reference molecule acarbose. Regarding antifungal activity, evaluated by well method against three fungal strains, the Aspergillus niveus extract showed an important effect against the yeast Candida albicans with an inhibition zone diameter of 24.6 mm. Moreover, the MTS assay indicated cytotoxicity of the three fungal strains against the used cell lines recording 100  mortality for Aspergillus quadrilineatus at 0.5 mgmL and 0.25 mgmL concentrations, and for Aspergillus niveus and Aspergillus wentii at 0.5 mgmL against the MCF-7 tumor cell line.

Makale detayları

Biological activities assessment of secondary metabolites derived from Aspergillus species

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.29 Issue 4, pp.1562-1572

Belge Tipi: Makale

Yayın Tarihi: 5/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001342456

pISSN: 2630-6344

Aspergillus quadrilineatus

Aspergillus niveus

Aspergillus wentii

secondary metabolites

biological activities

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 4, pp.1562-1572

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342456

pISSN:

2630-6344