The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis

Ayetullah TEMİZ; Mesut IŞIK; Yavuz ALBAYRAK; Hatice Esra DURAN; Adem ASLAN; Yeliz DEMİR; Ayse ALBAYRAK; Mesut IŞIK; Şükrü BEYDEMİR

doi:https://doi.org/10.15671/hjbc.728686

Makale detayları

The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis

Yazarlar:

Ayetullah TEMİZ | Mesut IŞIK | Yavuz ALBAYRAK | Hatice Esra DURAN | Adem ASLAN | Yeliz DEMİR | Ayse ALBAYRAK | Mesut IŞIK | Şükrü BEYDEMİR

Yayıncı:

Hacettepe University

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Hacettepe Journal of Biology and Chemistry 2021 Vol.49 Issue 1, pp.69-78

Belge Tipi:

Makale

Yayın Tarihi:

12/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000448178

Sıklık:

Üç Aylık

eISSN:

2687-475X

pISSN:

2687-475X

DOI:

https://doi.org/10.15671/hjbc.728686

Özet:

 

It is known that free radicals, their products and reactive oxygen species (ROS) are associated with many diseases. The study focuses on both some changes in oxidative stress factors in patients with acute appendicitis (AA) and the changes of GST and PON1 enzyme activities in the metabolism. This study involved control group (n = 31) and the study group (n = 52). In the groups, some changes in oxidative stress factors and GST and PON1 enzyme activities which play an important role in metabolism were determined.  There are changes in GST activity between study and control groups. The activity of the enzyme were significantly higher in AA groups (p < 0.01) than control. Malondialdehyde (MDA) levels in acute perforated appendicitis (PeA) groups were found significantly higher than control (p <0.01). There is a negative correlation between mean platelet volume (MPV) and lipid peroxidation in AA patients (r=-0.654, p<0.01). An increase in GSH production and GST activity provides an important defense mechanism against the oxidation of some macromolecules and may prevent oxidative stress in patients with appendicitis to some extent.

Makale detayları

The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis

Yazarlar: Ayetullah TEMİZ | Mesut IŞIK | Yavuz ALBAYRAK | Hatice Esra DURAN | Adem ASLAN | Yeliz DEMİR | Ayse ALBAYRAK | Mesut IŞIK | Şükrü BEYDEMİR

Yayıncı: Hacettepe University

Ana Başlıklar: Uygulamalı fizik

Dergi: Hacettepe Journal of Biology and Chemistry 2021 Vol.49 Issue 1, pp.69-78

Belge Tipi: Makale

Yayın Tarihi: 12/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000448178

Sıklık: Üç Aylık

eISSN: 2687-475X

pISSN: 2687-475X

DOI: https://doi.org/10.15671/hjbc.728686

Sayı

Yazarlar:

Ayetullah TEMİZ | Mesut IŞIK | Yavuz ALBAYRAK | Hatice Esra DURAN | Adem ASLAN | Yeliz DEMİR | Ayse ALBAYRAK | Mesut IŞIK | Şükrü BEYDEMİR

Yayıncı:

Hacettepe University

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Hacettepe Journal of Biology and Chemistry 2021 Vol.49 Issue 1, pp.69-78

Belge Tipi:

Makale

Yayın Tarihi:

12/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000448178

Sıklık:

Üç Aylık

eISSN:

2687-475X

pISSN:

2687-475X

DOI:

https://doi.org/10.15671/hjbc.728686