In vitro Cytogenotoxic Effects of a Coumarin-Selenophene Hybrid Compound

Hasan İla

Makale detayları

In vitro Cytogenotoxic Effects of a Coumarin-Selenophene Hybrid Compound

Yazarlar:

Hasan İla

Yayıncı:

Cukurova University

Ana Başlıklar:

Cell Development | Proliferation and Death

Dergi:

Cukurova University Journal of Natural and Applied Sciences Vol.3 Issue 1, pp.11-18

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001317281

pISSN:

2822-2938

Anahtar kelimeler:

Özet:

 This study was carried out to reveal the in vitro cytogenotoxic effect of 2-amino-5-6-bromo-2-oxo-2H-chromen-3-yl selenophene-3-carbonitrile 6-BrCoumSel or CoumSel, a newly synthesized coumarin-selenophene hybrid compound. Coumarin 2H-chromen-2-one, one of the main components of the test substance hybrid molecule CoumSel, is an aromatic organic chemical compound with the formula C9H6O2. Pharmacologically, coumarin belongs to the flavonoid group of chemicals. The other component, selenophene, has the formula C4H4Se and is an unsaturated organic compound containing a five-membered ring containing selenium in its structure. It is a colorless liquid and is one of the most common selenium heterocycles. It was found that in human lymphocytes cultured in vitro, the hybrid CoumSel compound increased the frequency of chromosome abnormalities CA and micronuclei MN, especially at high concentrations, compared to the untreated group 0 µgml. The potential of CoumSel as an antiproliferative drug with its current properties should not be ignored.

 This study was carried out to reveal the in vitro cytogenotoxic effect of 2-amino-5-6-bromo-2-oxo-2H-chromen-3-yl selenophene-3-carbonitrile 6-BrCoumSel or CoumSel, a newly synthesized coumarin-selenophene hybrid compound. Coumarin 2H-chromen-2-one, one of the main components of the test substance hybrid molecule CoumSel, is an aromatic organic chemical compound with the formula C9H6O2. Pharmacologically, coumarin belongs to the flavonoid group of chemicals. The other component, selenophene, has the formula C4H4Se and is an unsaturated organic compound containing a five-membered ring containing selenium in its structure. It is a colorless liquid and is one of the most common selenium heterocycles. It was found that in human lymphocytes cultured in vitro, the hybrid CoumSel compound increased the frequency of chromosome abnormalities CA and micronuclei MN, especially at high concentrations, compared to the untreated group 0 µgml. The potential of CoumSel as an antiproliferative drug with its current properties should not be ignored.

 This study was carried out to reveal the in vitro cytogenotoxic effect of 2-amino-5-6-bromo-2-oxo-2H-chromen-3-yl selenophene-3-carbonitrile 6-BrCoumSel or CoumSel, a newly synthesized coumarin-selenophene hybrid compound. Coumarin 2H-chromen-2-one, one of the main components of the test substance hybrid molecule CoumSel, is an aromatic organic chemical compound with the formula C9H6O2. Pharmacologically, coumarin belongs to the flavonoid group of chemicals. The other component, selenophene, has the formula C4H4Se and is an unsaturated organic compound containing a five-membered ring containing selenium in its structure. It is a colorless liquid and is one of the most common selenium heterocycles. It was found that in human lymphocytes cultured in vitro, the hybrid CoumSel compound increased the frequency of chromosome abnormalities CA and micronuclei MN, especially at high concentrations, compared to the untreated group 0 µgml. The potential of CoumSel as an antiproliferative drug with its current properties should not be ignored.

 This study was carried out to reveal the in vitro cytogenotoxic effect of 2-amino-5-6-bromo-2-oxo-2H-chromen-3-yl selenophene-3-carbonitrile 6-BrCoumSel or CoumSel, a newly synthesized coumarin-selenophene hybrid compound. Coumarin 2H-chromen-2-one, one of the main components of the test substance hybrid molecule CoumSel, is an aromatic organic chemical compound with the formula C9H6O2. Pharmacologically, coumarin belongs to the flavonoid group of chemicals. The other component, selenophene, has the formula C4H4Se and is an unsaturated organic compound containing a five-membered ring containing selenium in its structure. It is a colorless liquid and is one of the most common selenium heterocycles. It was found that in human lymphocytes cultured in vitro, the hybrid CoumSel compound increased the frequency of chromosome abnormalities CA and micronuclei MN, especially at high concentrations, compared to the untreated group 0 µgml. The potential of CoumSel as an antiproliferative drug with its current properties should not be ignored.

Makale detayları

In vitro Cytogenotoxic Effects of a Coumarin-Selenophene Hybrid Compound

Yazarlar:

Hasan İla

Yayıncı:

Cukurova University

Ana Başlıklar:

Cell Development | Proliferation and Death

Dergi:

Cukurova University Journal of Natural and Applied Sciences Vol.3 Issue 1, pp.11-18

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001317281

pISSN:

2822-2938

Coumarin-selenophene hybrid compound

in vitro human lymphocyte

chromosome aberration

Sayı

Makale detayları

In vitro Cytogenotoxic Effects of a Coumarin-Selenophene Hybrid Compound

Yazarlar: Hasan İla

Yayıncı: Cukurova University

Ana Başlıklar: Cell Development | Proliferation and Death

Dergi: Cukurova University Journal of Natural and Applied Sciences Vol.3 Issue 1, pp.11-18

Belge Tipi: Makale

Yayın Tarihi: 6/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001317281

pISSN: 2822-2938

Coumarin-selenophene hybrid compound

in vitro human lymphocyte

chromosome aberration

Sayı

Yazarlar:

Hasan İla

Yayıncı:

Cukurova University

Ana Başlıklar:

Cell Development | Proliferation and Death

Dergi:

Cukurova University Journal of Natural and Applied Sciences Vol.3 Issue 1, pp.11-18

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001317281

pISSN:

2822-2938