Comparison of biomarkers of COVID-19 patients with the alpha variant (B.1.1.7), the delta variant (B.1.617), and no mutation detected

Sanem Karadağ Gencer

Makale detayları

Comparison of biomarkers of COVID-19 patients with the alpha variant (B.1.1.7), the delta variant (B.1.617), and no mutation detected

Yazarlar:

Sanem Karadağ Gencer

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Medical Microbiology

Dergi:

The European Research Journal Vol.9 Issue 2, pp.244-252

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001283009

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: We aimed to compare biomarkers of COVID-19 patients with the Alpha variant B.1.1.7, the Delta variant B.1.617, and no mutation detected in our study. Methods: A total of 600 patients with positive COVID PCR test and Alpha, Delta variant and no mutation detected with Covid PCR mutation test were included in the study. Troponin I, creatinine, Alanine Aminotransferase ALT, Aspartate Aminotransferase AST, Lactate Dehydrogenase LDH, fibrinogen, D-dimer, ferritin, number of lymphocytes, lymphocytes , platelet PLT, mean platelet volume MPV, platelet distribution width PDW, trombosite ratio in the blood PCT, C-reactive protein CRP values were analyzed retrospectively. The age, gender, and hospitalization of the patients were evaluated concurrently. Results: Age, troponin, creatinine, LDH, PLT, MPV, and D-dimer were laboratory parameters that vary significantly with COVID-19 virus mutation. Age, troponin, LDH, and MPV values were lower in patients with Delta variant according to patients with the Alpha variant. Lymphocytes N and lymphocytes  values were lower in hospitalized patients relative to outpatients while age, troponin, LDH, CRP, and D-dimer values were higher in hospitalized patients than outpatients irrespective of mutation. Creatinine values were higher only in hospitalized patients with no mutation detected while ferritin and fibrinogen values were higher in hospitalized patients with Delta variant and no mutation detected. Conclusions: Age, troponin, creatinine, LDH, PLT, MPV, D-dimer, fibrinogen, ferritin, CRP, lymphocytes N, and lymphocytes  values can guide to evaluate the diagnosis and hospitalization of patients with future different mutations.

 Objectives: We aimed to compare biomarkers of COVID-19 patients with the Alpha variant B.1.1.7, the Delta variant B.1.617, and no mutation detected in our study. Methods: A total of 600 patients with positive COVID PCR test and Alpha, Delta variant and no mutation detected with Covid PCR mutation test were included in the study. Troponin I, creatinine, Alanine Aminotransferase ALT, Aspartate Aminotransferase AST, Lactate Dehydrogenase LDH, fibrinogen, D-dimer, ferritin, number of lymphocytes, lymphocytes , platelet PLT, mean platelet volume MPV, platelet distribution width PDW, trombosite ratio in the blood PCT, C-reactive protein CRP values were analyzed retrospectively. The age, gender, and hospitalization of the patients were evaluated concurrently. Results: Age, troponin, creatinine, LDH, PLT, MPV, and D-dimer were laboratory parameters that vary significantly with COVID-19 virus mutation. Age, troponin, LDH, and MPV values were lower in patients with Delta variant according to patients with the Alpha variant. Lymphocytes N and lymphocytes  values were lower in hospitalized patients relative to outpatients while age, troponin, LDH, CRP, and D-dimer values were higher in hospitalized patients than outpatients irrespective of mutation. Creatinine values were higher only in hospitalized patients with no mutation detected while ferritin and fibrinogen values were higher in hospitalized patients with Delta variant and no mutation detected. Conclusions: Age, troponin, creatinine, LDH, PLT, MPV, D-dimer, fibrinogen, ferritin, CRP, lymphocytes N, and lymphocytes  values can guide to evaluate the diagnosis and hospitalization of patients with future different mutations.

 Objectives: We aimed to compare biomarkers of COVID-19 patients with the Alpha variant B.1.1.7, the Delta variant B.1.617, and no mutation detected in our study. Methods: A total of 600 patients with positive COVID PCR test and Alpha, Delta variant and no mutation detected with Covid PCR mutation test were included in the study. Troponin I, creatinine, Alanine Aminotransferase ALT, Aspartate Aminotransferase AST, Lactate Dehydrogenase LDH, fibrinogen, D-dimer, ferritin, number of lymphocytes, lymphocytes , platelet PLT, mean platelet volume MPV, platelet distribution width PDW, trombosite ratio in the blood PCT, C-reactive protein CRP values were analyzed retrospectively. The age, gender, and hospitalization of the patients were evaluated concurrently. Results: Age, troponin, creatinine, LDH, PLT, MPV, and D-dimer were laboratory parameters that vary significantly with COVID-19 virus mutation. Age, troponin, LDH, and MPV values were lower in patients with Delta variant according to patients with the Alpha variant. Lymphocytes N and lymphocytes  values were lower in hospitalized patients relative to outpatients while age, troponin, LDH, CRP, and D-dimer values were higher in hospitalized patients than outpatients irrespective of mutation. Creatinine values were higher only in hospitalized patients with no mutation detected while ferritin and fibrinogen values were higher in hospitalized patients with Delta variant and no mutation detected. Conclusions: Age, troponin, creatinine, LDH, PLT, MPV, D-dimer, fibrinogen, ferritin, CRP, lymphocytes N, and lymphocytes  values can guide to evaluate the diagnosis and hospitalization of patients with future different mutations.

 Objectives: We aimed to compare biomarkers of COVID-19 patients with the Alpha variant B.1.1.7, the Delta variant B.1.617, and no mutation detected in our study. Methods: A total of 600 patients with positive COVID PCR test and Alpha, Delta variant and no mutation detected with Covid PCR mutation test were included in the study. Troponin I, creatinine, Alanine Aminotransferase ALT, Aspartate Aminotransferase AST, Lactate Dehydrogenase LDH, fibrinogen, D-dimer, ferritin, number of lymphocytes, lymphocytes , platelet PLT, mean platelet volume MPV, platelet distribution width PDW, trombosite ratio in the blood PCT, C-reactive protein CRP values were analyzed retrospectively. The age, gender, and hospitalization of the patients were evaluated concurrently. Results: Age, troponin, creatinine, LDH, PLT, MPV, and D-dimer were laboratory parameters that vary significantly with COVID-19 virus mutation. Age, troponin, LDH, and MPV values were lower in patients with Delta variant according to patients with the Alpha variant. Lymphocytes N and lymphocytes  values were lower in hospitalized patients relative to outpatients while age, troponin, LDH, CRP, and D-dimer values were higher in hospitalized patients than outpatients irrespective of mutation. Creatinine values were higher only in hospitalized patients with no mutation detected while ferritin and fibrinogen values were higher in hospitalized patients with Delta variant and no mutation detected. Conclusions: Age, troponin, creatinine, LDH, PLT, MPV, D-dimer, fibrinogen, ferritin, CRP, lymphocytes N, and lymphocytes  values can guide to evaluate the diagnosis and hospitalization of patients with future different mutations.

Makale detayları

Comparison of biomarkers of COVID-19 patients with the alpha variant (B.1.1.7), the delta variant (B.1.617), and no mutation detected

Yazarlar: Sanem Karadağ Gencer

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Medical Microbiology

Dergi: The European Research Journal Vol.9 Issue 2, pp.244-252

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001283009

pISSN: 2149-3189

COVID-19

alpha

delta

mutation

biomarker

Sayı

Yazarlar:

Sanem Karadağ Gencer

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Medical Microbiology

Dergi:

The European Research Journal Vol.9 Issue 2, pp.244-252

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001283009

pISSN:

2149-3189