Investigation of the effect of sildenafil citrate on flap survival and SOD, GPx antioxidant enzymes in random pattern skin flaps

Rukiye Demir; Emine Dıraman

Makale detayları

Investigation of the effect of sildenafil citrate on flap survival and SOD, GPx antioxidant enzymes in random pattern skin flaps

Yazarlar:

Rukiye Demir | Emine Dıraman

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Plastic Reconstructive and Aesthetic Surgery

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.42 Issue 1, pp.26-31

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344475

pISSN:

1309-4483

Anahtar kelimeler:

Özet:

 In this study, the effect of sildenafil citrate, a phosphodiesterase type 5 PDE 5 enzyme inhibitor, on the survival area of random pattern skin flaps and the effect of superoxide dismutase SOD and glutathione peoxidase GPx enzyme activities were investigated. Sildenafil citrate increases the level of cyclic guanosine monophosphate cGMP by inhibiting PDE 5. This causes dilation of the vessels and increased blood flow. In the study, 42 Wistar albino female rats weighing between 200-250 g were used. Rats were divided into 3 groups as sham group S, experimental group E and control group C. Subgroups were formed as day 1, day 4 and day 7 in groups E and C. In group E, 9 mgkgday sildenafil citrate was given intraperitoneally. Tissue samples were taken from the base, centre and the farthest living area of the flap of the sacrificed rats. SOD and GPx enzyme activity values were determined in the tissue samples. When SOD and GPx activities were compared between the groups, the difference was not significant p0.05. When the surviving flap areas were compared between the groups, an increase in necrotic area in the C7 group flaps was remarkable. However, there was no statistical difference between the groups in terms of flap survival area percentages p0.05.

 In this study, the effect of sildenafil citrate, a phosphodiesterase type 5 PDE 5 enzyme inhibitor, on the survival area of random pattern skin flaps and the effect of superoxide dismutase SOD and glutathione peoxidase GPx enzyme activities were investigated. Sildenafil citrate increases the level of cyclic guanosine monophosphate cGMP by inhibiting PDE 5. This causes dilation of the vessels and increased blood flow. In the study, 42 Wistar albino female rats weighing between 200-250 g were used. Rats were divided into 3 groups as sham group S, experimental group E and control group C. Subgroups were formed as day 1, day 4 and day 7 in groups E and C. In group E, 9 mgkgday sildenafil citrate was given intraperitoneally. Tissue samples were taken from the base, centre and the farthest living area of the flap of the sacrificed rats. SOD and GPx enzyme activity values were determined in the tissue samples. When SOD and GPx activities were compared between the groups, the difference was not significant p0.05. When the surviving flap areas were compared between the groups, an increase in necrotic area in the C7 group flaps was remarkable. However, there was no statistical difference between the groups in terms of flap survival area percentages p0.05.

 In this study, the effect of sildenafil citrate, a phosphodiesterase type 5 PDE 5 enzyme inhibitor, on the survival area of random pattern skin flaps and the effect of superoxide dismutase SOD and glutathione peoxidase GPx enzyme activities were investigated. Sildenafil citrate increases the level of cyclic guanosine monophosphate cGMP by inhibiting PDE 5. This causes dilation of the vessels and increased blood flow. In the study, 42 Wistar albino female rats weighing between 200-250 g were used. Rats were divided into 3 groups as sham group S, experimental group E and control group C. Subgroups were formed as day 1, day 4 and day 7 in groups E and C. In group E, 9 mgkgday sildenafil citrate was given intraperitoneally. Tissue samples were taken from the base, centre and the farthest living area of the flap of the sacrificed rats. SOD and GPx enzyme activity values were determined in the tissue samples. When SOD and GPx activities were compared between the groups, the difference was not significant p0.05. When the surviving flap areas were compared between the groups, an increase in necrotic area in the C7 group flaps was remarkable. However, there was no statistical difference between the groups in terms of flap survival area percentages p0.05.

 In this study, the effect of sildenafil citrate, a phosphodiesterase type 5 PDE 5 enzyme inhibitor, on the survival area of random pattern skin flaps and the effect of superoxide dismutase SOD and glutathione peoxidase GPx enzyme activities were investigated. Sildenafil citrate increases the level of cyclic guanosine monophosphate cGMP by inhibiting PDE 5. This causes dilation of the vessels and increased blood flow. In the study, 42 Wistar albino female rats weighing between 200-250 g were used. Rats were divided into 3 groups as sham group S, experimental group E and control group C. Subgroups were formed as day 1, day 4 and day 7 in groups E and C. In group E, 9 mgkgday sildenafil citrate was given intraperitoneally. Tissue samples were taken from the base, centre and the farthest living area of the flap of the sacrificed rats. SOD and GPx enzyme activity values were determined in the tissue samples. When SOD and GPx activities were compared between the groups, the difference was not significant p0.05. When the surviving flap areas were compared between the groups, an increase in necrotic area in the C7 group flaps was remarkable. However, there was no statistical difference between the groups in terms of flap survival area percentages p0.05.

Makale detayları

Investigation of the effect of sildenafil citrate on flap survival and SOD, GPx antioxidant enzymes in random pattern skin flaps

Yazarlar:

Rukiye Demir | Emine Dıraman

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Plastic Reconstructive and Aesthetic Surgery

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.42 Issue 1, pp.26-31

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344475

pISSN:

1309-4483

flap

sildenafil citrate

superoxide dismutase

glutathione peroxidase

Sayı

Makale detayları

Investigation of the effect of sildenafil citrate on flap survival and SOD, GPx antioxidant enzymes in random pattern skin flaps

Yazarlar: Rukiye Demir | Emine Dıraman

Yayıncı: Ondokuz Mayıs University

Ana Başlıklar: Plastic Reconstructive and Aesthetic Surgery

Dergi: Deneysel ve Klinik Tıp Dergisi Vol.42 Issue 1, pp.26-31

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001344475

pISSN: 1309-4483

flap

sildenafil citrate

superoxide dismutase

glutathione peroxidase

Sayı

Yazarlar:

Rukiye Demir | Emine Dıraman

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Plastic Reconstructive and Aesthetic Surgery

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.42 Issue 1, pp.26-31

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344475

pISSN:

1309-4483