Effects of Inhalation Anesthetics on Respiratory Mechanics

Burak Erken; Fatiş Altıntaş; Tuğhan Utku; Pınar Kendigelen; Çiğdem Tütüncü; Birsel Ekici; Şafak Emre Erbabacan; Aylin Nizamoğlu; Cigdem Akyol Beyoglu; Güniz Meyancı; Güner Kaya

Makale detayları

Effects of Inhalation Anesthetics on Respiratory Mechanics

Yazarlar:

Burak Erken | Fatiş Altıntaş | Tuğhan Utku | Pınar Kendigelen | Çiğdem Tütüncü | Birsel Ekici | Şafak Emre Erbabacan | Aylin Nizamoğlu | Cigdem Akyol Beyoglu | Güniz Meyancı | Güner Kaya

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

Anesteziyoloji

Dergi:

Osmangazi Tıp Dergisi Vol.47 Issue 4, pp.567-575

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343018

pISSN:

1305-4953

Anahtar kelimeler:

Özet:

 This study aimed to compare the effects of sevoflurane and desflurane on respiratory mechanics during general anesthesia in pediatric patients with respiratory problems. This prospective, randomized study included 40 pediatric patients 6 girls and 34 boys, aged 1-6 years, who underwent elective lower urinary tract surgery e.g., orchiopexy and hypospadias repair under general anesthesia at our university hospital between February 1, 2015, and May 1, 2015. Patients were assigned to two groups based on the administered inhalation agent: sevoflurane or desflurane. Airway resistance RAW, dynamic compliance Cdyn, peak inspiratory pressure PIP, and plateau pressure Pplato were measured at multiple time points during general anesthesia at 1, 3, 6, 10, 15, 20, 30, 40, 60, 90, 120 min and after intubation. The values were then compared between the groups There were no statistically significant differences between the sevoflurane and desflurane groups regarding RAW, Cdyn, PIP, and Pplato values p 0.05. Sevoflurane and desflurane are both viable options for maintaining general anesthesia in children with RADS. However, additional studies are required to identify the safest anesthetic agents, especially in pediatric patients with underlying respiratory issues.

 This study aimed to compare the effects of sevoflurane and desflurane on respiratory mechanics during general anesthesia in pediatric patients with respiratory problems. This prospective, randomized study included 40 pediatric patients 6 girls and 34 boys, aged 1-6 years, who underwent elective lower urinary tract surgery e.g., orchiopexy and hypospadias repair under general anesthesia at our university hospital between February 1, 2015, and May 1, 2015. Patients were assigned to two groups based on the administered inhalation agent: sevoflurane or desflurane. Airway resistance RAW, dynamic compliance Cdyn, peak inspiratory pressure PIP, and plateau pressure Pplato were measured at multiple time points during general anesthesia at 1, 3, 6, 10, 15, 20, 30, 40, 60, 90, 120 min and after intubation. The values were then compared between the groups There were no statistically significant differences between the sevoflurane and desflurane groups regarding RAW, Cdyn, PIP, and Pplato values p 0.05. Sevoflurane and desflurane are both viable options for maintaining general anesthesia in children with RADS. However, additional studies are required to identify the safest anesthetic agents, especially in pediatric patients with underlying respiratory issues.

 This study aimed to compare the effects of sevoflurane and desflurane on respiratory mechanics during general anesthesia in pediatric patients with respiratory problems. This prospective, randomized study included 40 pediatric patients 6 girls and 34 boys, aged 1-6 years, who underwent elective lower urinary tract surgery e.g., orchiopexy and hypospadias repair under general anesthesia at our university hospital between February 1, 2015, and May 1, 2015. Patients were assigned to two groups based on the administered inhalation agent: sevoflurane or desflurane. Airway resistance RAW, dynamic compliance Cdyn, peak inspiratory pressure PIP, and plateau pressure Pplato were measured at multiple time points during general anesthesia at 1, 3, 6, 10, 15, 20, 30, 40, 60, 90, 120 min and after intubation. The values were then compared between the groups There were no statistically significant differences between the sevoflurane and desflurane groups regarding RAW, Cdyn, PIP, and Pplato values p 0.05. Sevoflurane and desflurane are both viable options for maintaining general anesthesia in children with RADS. However, additional studies are required to identify the safest anesthetic agents, especially in pediatric patients with underlying respiratory issues.

 Reaktif hava yolu disfonksiyon sendromu gibi solunum problemleri olan pediatrik hastalarda, genel anestezi sırasında kullanılan inhalasyon anesteziklerinin sevofluran ve desfluran hastalarda introperatif dönemde solunum mekanikleri üzerindeki etkilerinin karşılaştırılması hedeflenmiştir. Prospektif, randomize olarak dizayn edilen bu çalışmada, elektif alt üriner sistem cerrahisi örneğin, orşiopeksi ve hipospadias onarımı nedeniyle genel anestezi verilen, RADS tanılı, 1-6 yaş arası 40 pediatrik hasta 6 kız ve 34 erkek bulunmaktadır. Hastalar, anestezi idamesi için uygulanan inhalasyon ajanına göre , sevfluran ve desfluran olacak şekilde, iki gruba ayrılmıştır. Hava yolu direnci RAW, dinamik kompliyans Cdyn, pik inspiratuar basınç PIP ve plato basıncı Pplato değerleri, genel anestezi süresince entübasyondan sonra, 1, 3, 6, 10, 15, 20, 30, 40, 60, 90 ve 120. dakikalarda kaydedilmiş ve karşılaştırılmıştır. Gruplar arasında RAW, Cdyn, PIP ve Pplato değerleri açısından istatistiksel olarak anlamlı fark saptanmamıştır. p  0,05. RADSlı çocuklarda genel anestezinin idamesinde sevofluran ve desfluran kullanımı ile hastalarda intraoperatif havayolu basınçları üzerinde gruplar arasında istatistiksel anlamlı fark saptanmamış olup, daha çok hasta sayıları ile yapılacak çalışmalara da ihtiyaç olduğu vurgusu ile, RADS tanılı hastalarda anestezi idamesi için sevofluran ve desfluranın güvenle kullanılabileceğini düşünmekteyiz.

Makale detayları

Effects of Inhalation Anesthetics on Respiratory Mechanics

Yazarlar:

Burak Erken | Fatiş Altıntaş | Tuğhan Utku | Pınar Kendigelen | Çiğdem Tütüncü | Birsel Ekici | Şafak Emre Erbabacan | Aylin Nizamoğlu | Cigdem Akyol Beyoglu | Güniz Meyancı | Güner Kaya

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

Anesteziyoloji

Dergi:

Osmangazi Tıp Dergisi Vol.47 Issue 4, pp.567-575

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343018

pISSN:

1305-4953

reactive airway dysfunction syndrome

respiratory mechanics

inhalation anesthetics

sevoflurane

desfluranereaktif hava yolu disfonksiyon sendromu

solunum mekanikleri

inhalasyon anestezikleri

sevofluran

desfluran

Sayı

Makale detayları

Yazarlar: Burak Erken | Fatiş Altıntaş | Tuğhan Utku | Pınar Kendigelen | Çiğdem Tütüncü | Birsel Ekici | Şafak Emre Erbabacan | Aylin Nizamoğlu | Cigdem Akyol Beyoglu | Güniz Meyancı | Güner Kaya

Yayıncı: Eskişehir Osmangazi University

Ana Başlıklar: Anesteziyoloji

Dergi: Osmangazi Tıp Dergisi Vol.47 Issue 4, pp.567-575

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001343018

pISSN: 1305-4953

Sayı

Yazarlar:

Burak Erken | Fatiş Altıntaş | Tuğhan Utku | Pınar Kendigelen | Çiğdem Tütüncü | Birsel Ekici | Şafak Emre Erbabacan | Aylin Nizamoğlu | Cigdem Akyol Beyoglu | Güniz Meyancı | Güner Kaya

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

Anesteziyoloji

Dergi:

Osmangazi Tıp Dergisi Vol.47 Issue 4, pp.567-575

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343018

pISSN:

1305-4953