Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H -benzimidazoles

Ayşe Selen ALP; Gülgün KILCIGİL; Elçin Deniz ÖZDAMAR; Tülay ÇOBAN; Binay EKE

doi:https://doi.org/10.3906/kim-1403-44

Makale detayları

Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H -benzimidazoles

Yazarlar:

Ayşe Selen ALP | Gülgün KILCIGİL | Elçin Deniz ÖZDAMAR | Tülay ÇOBAN | Binay EKE

Yayıncı:

TUBITAK

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Turkish Journal of Chemistry 2015 Vol.39 Issue 1, pp.42-53

Belge Tipi:

Makale

Yayın Tarihi:

3/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000726959

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1403-44

Özet:

 

Some novel  2-(substitutedbenzylthio)-5-((2-(4-substitutedphenyl)-1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazoles  (5--12) and  2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-N'-(arylmethylene)acetohydrazide  derivatives (13--22) were prepared and their in vitro  antioxidant properties were investigated by determination of rat liver  microsomal NADPH-dependent inhibition of lipid peroxidation (LP) levels and  microsomal ethoxyresorufin O-deethylase (EROD) activity. Compound  18 was found to be the most active compound with 100% inhibition  on LP level and 92% inhibition on EROD. Compounds 4b,  17, and 19 showed the strongest inhibitory effect (97%)  on EROD. The free radical scavenging capacities of the compounds were also  tested in vitro determining the interaction of the stable free radical  2,2,diphenyl-1-picrylhydrazyl (DPPH), and compounds 4a and  4b exhibited good antioxidant activities.

 

Some novel  2-(substitutedbenzylthio)-5-((2-(4-substitutedphenyl)-1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazoles  (5--12) and  2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-N'-(arylmethylene)acetohydrazide  derivatives (13--22) were prepared and their in vitro  antioxidant properties were investigated by determination of rat liver  microsomal NADPH-dependent inhibition of lipid peroxidation (LP) levels and  microsomal ethoxyresorufin O-deethylase (EROD) activity. Compound  18 was found to be the most active compound with 100% inhibition  on LP level and 92% inhibition on EROD. Compounds 4b,  17, and 19 showed the strongest inhibitory effect (97%)  on EROD. The free radical scavenging capacities of the compounds were also  tested in vitro determining the interaction of the stable free radical  2,2,diphenyl-1-picrylhydrazyl (DPPH), and compounds 4a and  4b exhibited good antioxidant activities.

Makale detayları

Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H -benzimidazoles

Yazarlar: Ayşe Selen ALP | Gülgün KILCIGİL | Elçin Deniz ÖZDAMAR | Tülay ÇOBAN | Binay EKE

Yayıncı: TUBITAK

Ana Başlıklar: Kimya ve ilgili bilimler

Dergi: Turkish Journal of Chemistry 2015 Vol.39 Issue 1, pp.42-53

Belge Tipi: Makale

Yayın Tarihi: 3/2015

Belge Dili: İngilizce

Document ID (Org No.): 2000726959

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

DOI: https://doi.org/10.3906/kim-1403-44

Sayı

Yazarlar:

Ayşe Selen ALP | Gülgün KILCIGİL | Elçin Deniz ÖZDAMAR | Tülay ÇOBAN | Binay EKE

Yayıncı:

TUBITAK

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Turkish Journal of Chemistry 2015 Vol.39 Issue 1, pp.42-53

Belge Tipi:

Makale

Yayın Tarihi:

3/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000726959

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1403-44