Synthesis, characterization, and antibacterial effect of 4-methoxy-2-(5-H/Me/Cl/NO2-1H-benzimidazol-2-yl)- phenols and some transition metal complexes

Aydın TAVMAN; Serkan İKİZ; A. Funda BAĞCIGİL; N. Yakut ÖZGÜR; Seyyal AK

Makale detayları

Synthesis, characterization, and antibacterial effect of 4-methoxy-2-(5-H/Me/Cl/NO2-1H-benzimidazol-2-yl)- phenols and some transition metal complexes

Yazarlar:

Aydın TAVMAN | Serkan İKİZ | A. Funda BAĞCIGİL | N. Yakut ÖZGÜR | Seyyal AK

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2009 Vol.33 Issue 3, pp.321-331

Belge Tipi:

Makale

Yayın Tarihi:

2/2009

Belge Dili:

İngilizce

Document ID (Org No.):

2000728279

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

4-Methoxy-2-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl)-phenol(HLX; X=1-4) ligands and HL1 complexes with Fe(NO3)3,   Cu(NO3)2,  AgNO3, and Zn(NO3)2 were synthesized and characterized.  The  structures of the compounds were confirmed on the basis of elemental  analysis, molar conductivity, magnetic moment, FT-IR, UV-visible, and  1H- and 13C-NMR. Antibacterial activity of the free ligands, their hydrochloride salts, and the complexes was evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimum  inhibitory concentration (MIC) dilution method, against 9 bacteria,  and the results were compared with penicillin-G and oxytetracycline.  It was observed that HL1, [Ag(HL1)](NO3), and [Cu(L1)2](H2O)2  are effective on S. epidermidis, S. aureus, and B. subtilis (gram+)  organisms compared with the other compounds.  All compounds except  HL4 and [Zn(L1)(H2O)2]NO3 showed antibacterial activity on S.  aureus.

 

4-Methoxy-2-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl)-phenol(HLX; X=1-4) ligands and HL1 complexes with Fe(NO3)3,   Cu(NO3)2,  AgNO3, and Zn(NO3)2 were synthesized and characterized.  The  structures of the compounds were confirmed on the basis of elemental  analysis, molar conductivity, magnetic moment, FT-IR, UV-visible, and  1H- and 13C-NMR. Antibacterial activity of the free ligands, their hydrochloride salts, and the complexes was evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimum  inhibitory concentration (MIC) dilution method, against 9 bacteria,  and the results were compared with penicillin-G and oxytetracycline.  It was observed that HL1, [Ag(HL1)](NO3), and [Cu(L1)2](H2O)2  are effective on S. epidermidis, S. aureus, and B. subtilis (gram+)  organisms compared with the other compounds.  All compounds except  HL4 and [Zn(L1)(H2O)2]NO3 showed antibacterial activity on S.  aureus.

Makale detayları

Synthesis, characterization, and antibacterial effect of 4-methoxy-2-(5-H/Me/Cl/NO2-1H-benzimidazol-2-yl)- phenols and some transition metal complexes

Yazarlar: Aydın TAVMAN | Serkan İKİZ | A. Funda BAĞCIGİL | N. Yakut ÖZGÜR | Seyyal AK

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2009 Vol.33 Issue 3, pp.321-331

Belge Tipi: Makale

Yayın Tarihi: 2/2009

Belge Dili: İngilizce

Document ID (Org No.): 2000728279

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Aydın TAVMAN | Serkan İKİZ | A. Funda BAĞCIGİL | N. Yakut ÖZGÜR | Seyyal AK

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2009 Vol.33 Issue 3, pp.321-331

Belge Tipi:

Makale

Yayın Tarihi:

2/2009

Belge Dili:

İngilizce

Document ID (Org No.):

2000728279

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527