Synthesis, characterization, crystal structures, and antibacterial activity of some new 1-(3,4,5-trimethoxybenzoyl)-3-aryl thioureasreas

Aamer SAEED; Rasheed Ahmad KHERA; Naeem ABBAS; Muhammad LATIF

doi:https://doi.org/10.3906/sag-1206-11

Makale detayları

Synthesis, characterization, crystal structures, and antibacterial activity of some new 1-(3,4,5-trimethoxybenzoyl)-3-aryl thioureasreas

Yazarlar:

Aamer SAEED | Rasheed Ahmad KHERA | Naeem ABBAS | Muhammad LATIF

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2010 Vol.34 Issue 3, pp.335-346

Belge Tipi:

Makale

Yayın Tarihi:

2/2010

Belge Dili:

İngilizce

Document ID (Org No.):

2000728041

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/sag-1206-11

Özet:

 

Synthesis of some novel 1-(3,4,5-trimethoxy)benzoyl-3-  arylthiourea derivatives (1a-o) was accomplished in 2 steps.  The  synthetic route involves the reaction of 1-(3,4,5-trimethoxy)benzoyl  chloride with potassium thiocyanate in 1:1 molar ratio in acetone to  afford the corresponding isothiocyante followed by treatment with  suitably substituted anilines.  The structures of the products were  established by elemental analyses, IR, 1H- and 13C-NMR, and mass  spectroscopy and for 1b and 1m from single crystal X-ray diffraction  data.  All of the synthesized compounds (1a-o) were screened for  antibacterial activity against gram positive and gram negative  bacterial strains and were found to exhibit low activity towards the  tested microorganisms, compared to chloramphenicol, the standard drug.

 

Synthesis of some novel 1-(3,4,5-trimethoxy)benzoyl-3-  arylthiourea derivatives (1a-o) was accomplished in 2 steps.  The  synthetic route involves the reaction of 1-(3,4,5-trimethoxy)benzoyl  chloride with potassium thiocyanate in 1:1 molar ratio in acetone to  afford the corresponding isothiocyante followed by treatment with  suitably substituted anilines.  The structures of the products were  established by elemental analyses, IR, 1H- and 13C-NMR, and mass  spectroscopy and for 1b and 1m from single crystal X-ray diffraction  data.  All of the synthesized compounds (1a-o) were screened for  antibacterial activity against gram positive and gram negative  bacterial strains and were found to exhibit low activity towards the  tested microorganisms, compared to chloramphenicol, the standard drug.

Makale detayları

Synthesis, characterization, crystal structures, and antibacterial activity of some new 1-(3,4,5-trimethoxybenzoyl)-3-aryl thioureasreas

Yazarlar: Aamer SAEED | Rasheed Ahmad KHERA | Naeem ABBAS | Muhammad LATIF

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2010 Vol.34 Issue 3, pp.335-346

Belge Tipi: Makale

Yayın Tarihi: 2/2010

Belge Dili: İngilizce

Document ID (Org No.): 2000728041

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

DOI: https://doi.org/10.3906/sag-1206-11

Sayı

Yazarlar:

Aamer SAEED | Rasheed Ahmad KHERA | Naeem ABBAS | Muhammad LATIF

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2010 Vol.34 Issue 3, pp.335-346

Belge Tipi:

Makale

Yayın Tarihi:

2/2010

Belge Dili:

İngilizce

Document ID (Org No.):

2000728041

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/sag-1206-11