Synthesis and Isolation of New Regioisomeric 4-Thiazolidinones and Their Anticonvulsant Activity

Aysel GÜRSOY; Nalan TERZİOĞLU

Makale detayları

Synthesis and Isolation of New Regioisomeric 4-Thiazolidinones and Their Anticonvulsant Activity

Yazarlar:

Aysel GÜRSOY | Nalan TERZİOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2005 Vol.29 Issue 3, pp.247-254

Belge Tipi:

Makale

Yayın Tarihi:

2/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000729092

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Two regioisomer series, 2-(3-ethyl-4(3H)-quinazolinone-2-  ylmercaptoacetylhydrazono)-3-alkyl/3-aryl-5-methyl-4-thiazolidinones  (12-21) and 2-arylimino-3-(3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetylamino)-  5-methyl-4-thiazolidinones (22-26), were synthesized by the cyclization of  1-(3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetyl)-4-alkyl/aryl  thiosemicarbazides (1-11) with ethyl 2-bromopropionate in the  presence of anhydrous sodium acetate in anhydrous ethanolic medium.   The structures of 12-26 were confirmed by analytical and spectral  data (IR, 1H-NMR and EIMS).  Selected members of the thiosemicarbazides  and thiazolidinones were subjected to anticonvulsant activity tests by  the National Institute of Neurological Disorders and Stroke MD, USA.

 

Two regioisomer series, 2-(3-ethyl-4(3H)-quinazolinone-2-  ylmercaptoacetylhydrazono)-3-alkyl/3-aryl-5-methyl-4-thiazolidinones  (12-21) and 2-arylimino-3-(3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetylamino)-  5-methyl-4-thiazolidinones (22-26), were synthesized by the cyclization of  1-(3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetyl)-4-alkyl/aryl  thiosemicarbazides (1-11) with ethyl 2-bromopropionate in the  presence of anhydrous sodium acetate in anhydrous ethanolic medium.   The structures of 12-26 were confirmed by analytical and spectral  data (IR, 1H-NMR and EIMS).  Selected members of the thiosemicarbazides  and thiazolidinones were subjected to anticonvulsant activity tests by  the National Institute of Neurological Disorders and Stroke MD, USA.

Makale detayları

Synthesis and Isolation of New Regioisomeric 4-Thiazolidinones and Their Anticonvulsant Activity

Yazarlar: Aysel GÜRSOY | Nalan TERZİOĞLU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2005 Vol.29 Issue 3, pp.247-254

Belge Tipi: Makale

Yayın Tarihi: 2/2005

Belge Dili: Türkçe

Document ID (Org No.): 2000729092

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Aysel GÜRSOY | Nalan TERZİOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2005 Vol.29 Issue 3, pp.247-254

Belge Tipi:

Makale

Yayın Tarihi:

2/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000729092

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527