An Examination of the Frequency of Subclinical Hypothyroidism and Relevant Parameters in Obese Children and Adolescents

Aslı Beştaş; Edip Unal

Makale detayları

An Examination of the Frequency of Subclinical Hypothyroidism and Relevant Parameters in Obese Children and Adolescents

Yazarlar:

Aslı Beştaş | Edip Unal

Yayıncı:

Kirsehir Ahi Evran University

Ana Başlıklar:

Endokrinoloji

Dergi:

Ahi Evran Tıp Dergisi Vol.9 Issue 1, pp.44-50

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001344989

pISSN:

2619-9203

Anahtar kelimeler:

Özet:

 Purpose: Subclinical hypothyroidism SH is a thyroid hormone disorder commonly observed in obese children and adolescents. In this study, it was aimed to determine the frequency of subclinical hypothyroidism in obese children and adolescents and to investigate the relationship between TSH levels and anthropometric and metabolic parameters. Materials and Methods: A total of 170 patients aged 10-18 years were included in the study, 100 in the obese group and 70 in the control group. Gender, anthropometric measurements and laboratory data were obtained from the patients medical records. Results: SH was detected in 7 of the 100 patients 7 in the obese group. The BW and BMI SDS values were found significantly higher in the obese group compared to the control group p0.01,0.01, respectively.In the obese group, fT4 levels were signif-icantly lower p0.04 than in the control group, and HOMA-IR and AST levels were significantly higher p0.01, 0.01, re-spectively. A low positive correlation was found between serum TSH levels and HOMA IR levels r0.15, p0.049. Conclusion: Subclinical hypothyroidism SH is more common in obese children and adolescents compared to the general popu-lation; however, in most cases, TSH levels remain below 10 IUmL, and treatment is not required. In obese children, thyroid autoantibody positivity may be observed without Hashimotos thyroiditis. Since there is a weak but positive correlation between TSH levels and insulin resistance, the detection of SH in obese children should alert clinicians to the possibility of insulin resistance.

 Purpose: Subclinical hypothyroidism SH is a thyroid hormone disorder commonly observed in obese children and adolescents. In this study, it was aimed to determine the frequency of subclinical hypothyroidism in obese children and adolescents and to investigate the relationship between TSH levels and anthropometric and metabolic parameters. Materials and Methods: A total of 170 patients aged 10-18 years were included in the study, 100 in the obese group and 70 in the control group. Gender, anthropometric measurements and laboratory data were obtained from the patients medical records. Results: SH was detected in 7 of the 100 patients 7 in the obese group. The BW and BMI SDS values were found significantly higher in the obese group compared to the control group p0.01,0.01, respectively.In the obese group, fT4 levels were signif-icantly lower p0.04 than in the control group, and HOMA-IR and AST levels were significantly higher p0.01, 0.01, re-spectively. A low positive correlation was found between serum TSH levels and HOMA IR levels r0.15, p0.049. Conclusion: Subclinical hypothyroidism SH is more common in obese children and adolescents compared to the general popu-lation; however, in most cases, TSH levels remain below 10 IUmL, and treatment is not required. In obese children, thyroid autoantibody positivity may be observed without Hashimotos thyroiditis. Since there is a weak but positive correlation between TSH levels and insulin resistance, the detection of SH in obese children should alert clinicians to the possibility of insulin resistance.

 Purpose: Subclinical hypothyroidism SH is a thyroid hormone disorder commonly observed in obese children and adolescents. In this study, it was aimed to determine the frequency of subclinical hypothyroidism in obese children and adolescents and to investigate the relationship between TSH levels and anthropometric and metabolic parameters. Materials and Methods: A total of 170 patients aged 10-18 years were included in the study, 100 in the obese group and 70 in the control group. Gender, anthropometric measurements and laboratory data were obtained from the patients medical records. Results: SH was detected in 7 of the 100 patients 7 in the obese group. The BW and BMI SDS values were found significantly higher in the obese group compared to the control group p0.01,0.01, respectively.In the obese group, fT4 levels were signif-icantly lower p0.04 than in the control group, and HOMA-IR and AST levels were significantly higher p0.01, 0.01, re-spectively. A low positive correlation was found between serum TSH levels and HOMA IR levels r0.15, p0.049. Conclusion: Subclinical hypothyroidism SH is more common in obese children and adolescents compared to the general popu-lation; however, in most cases, TSH levels remain below 10 IUmL, and treatment is not required. In obese children, thyroid autoantibody positivity may be observed without Hashimotos thyroiditis. Since there is a weak but positive correlation between TSH levels and insulin resistance, the detection of SH in obese children should alert clinicians to the possibility of insulin resistance.

 Amaç: Subklinik hipotiroidizm SH, obez çocuk ve ergenlerde sık görülen bir tiroid hormon bozukluğudur. Bu çalışmada, obez çocuk ve ergenlerde subklinik hipotiroidi sıklığını belirlemek, TSH düzeyi ile antropometrik ve metabolik parametreler arasındaki ilişkinin araştırılması planlanmıştır. Araçlar ve Yöntem: Çalışmaya yaşları 10-18 yaş aralığından değişen 100 obez grup, 70 kontrol grubu olmak üzere toplam 170 olgu alındı. Tüm olguların dosya kayıtlarından; cinsiyet, antropometrik ölçümleri vücut ağırlığı, boy, beden kitle indeksleri ve standart deviasyon skorları SDS, tiroid fonksiyon testleri TSH, sT4, sT3, insülin, açlık kan şekeri, total kolesterol TK, yüksek dansiteli lipoprotein, kolesterol HDL-K, trigliserid ve düşük dansitelilipoprotein kolesterol LDL-K, HOMA-IR düzeyleri elde edildi. Bulgular: Obez gruptaki 100 hastanın 7sinde  7 SH saptandı. Obez grubun VA ve BKİ-SDS değerleri kontrol grubuna göre anlamlı derecede yüksek saptandı. p0.01,0.01, sırasıyla. Obez grupta sT4 düzeyi kontrol grubuna göre anlamlı düşük p0.04 , HOMA-IR ve AST düzeyi de anlamlı olarak yüksek bulundu p0.01, 0.01, sırasıyla. Serum TSH düzeyi ile HOMA-IR düzeyi arasında pozitif yönde düşük derecede korelasyon saptandı r0.15, p0.049. Sonuç: Obez çocuk ve ergenlerde SH normal popülasyona göre daha sık görülür, ancak çoğu olguda TSH 10 UImlnın altında ve tedaviye ihtiyaç duyulmamaktadır. Obez çocuklarda Hashimato tiroiditi olmaksızın tiroid otoantikor pozitifliği görülebilir. TSH düzeyi ile insülin direnci arasında düşük derecede de olsa pozitif bir ilişki olduğundan, obez çocuklarda SH saptanması insülin direnci olasılığı konusunda klinisyen için uyarıcı olmalıdır.

Makale detayları

An Examination of the Frequency of Subclinical Hypothyroidism and Relevant Parameters in Obese Children and Adolescents

Yazarlar:

Aslı Beştaş | Edip Unal

Yayıncı:

Kirsehir Ahi Evran University

Ana Başlıklar:

Endokrinoloji

Dergi:

Ahi Evran Tıp Dergisi Vol.9 Issue 1, pp.44-50

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001344989

pISSN:

2619-9203

body mass index

ınsulin resistance

obesity

thyroid hormonesbeden kitle indeksi

insülin direnci

obezite

tiroid hormonları

Sayı

Makale detayları

Yazarlar: Aslı Beştaş | Edip Unal

Yayıncı: Kirsehir Ahi Evran University

Ana Başlıklar: Endokrinoloji

Dergi: Ahi Evran Tıp Dergisi Vol.9 Issue 1, pp.44-50

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: Türkçe

Document ID (Org No.): 2001344989

pISSN: 2619-9203

Sayı

Yazarlar:

Aslı Beştaş | Edip Unal

Yayıncı:

Kirsehir Ahi Evran University

Ana Başlıklar:

Endokrinoloji

Dergi:

Ahi Evran Tıp Dergisi Vol.9 Issue 1, pp.44-50

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001344989

pISSN:

2619-9203