Prognostic importance of PET score obtained from IMPeTUS criteria in multiple myeloma

Özlem Beyler; İhsan Kaplan; Cengiz Demir; Canan Can; Halil Kömek

Makale detayları

Prognostic importance of PET score obtained from IMPeTUS criteria in multiple myeloma

Yazarlar:

Özlem Beyler | İhsan Kaplan | Cengiz Demir | Canan Can | Halil Kömek

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Nükleer Tıp | Hematolojik Tümörler

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 3, pp.430-434

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349466

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aim Multiple myeloma MM is a clonal plasma cell malignancy that infiltrates the bone marrow, bone, and sometimes extramedullary sites. Reliable staging and prognostic factors are essential for patient management. Imaging modalities, especially 18FFDG PETCT, are essential for the assessment of disease extent. This study evaluates a scoring system based on the IMPeTUs criteria for predicting progression-free survival PFS in MM. Materials and Methods This study included 35 newly diagnosed, treatment-naive MM patients 13 females, 22 males. Baseline 18FFDG PETCT scans were obtained within one month of diagnosis. Data on MM type, ISS stage, chemotherapy regimens and outcomes were collected. PETCT scans were evaluated using the IMPeTUs criteria, focusing on the Deauville 5-point scoring system for bone marrow and lesions. Results The mean age of the cohort was 65 years. Ig G kappa was the most common MM type 37.1. Diffuse bone marrow uptake and focal lesions were observed in 37.2 and 57.2 of patients, respectively, DS  4. The PET score cut-off of 6.5 predicted PFS with 61.5 sensitivity and 72.7 specificity AUC 0.715. Median PFS was significantly different between patients with PET score  6.5 and  6.5 35  4.1 months vs. 23.6  4.03 months, p  0.027. Conclusions The PET score cut-off value of 6.5 serves as a potential prognostic tool for MM, aiding in patient stratification and treatment decisions.

 Aim Multiple myeloma MM is a clonal plasma cell malignancy that infiltrates the bone marrow, bone, and sometimes extramedullary sites. Reliable staging and prognostic factors are essential for patient management. Imaging modalities, especially 18FFDG PETCT, are essential for the assessment of disease extent. This study evaluates a scoring system based on the IMPeTUs criteria for predicting progression-free survival PFS in MM. Materials and Methods This study included 35 newly diagnosed, treatment-naive MM patients 13 females, 22 males. Baseline 18FFDG PETCT scans were obtained within one month of diagnosis. Data on MM type, ISS stage, chemotherapy regimens and outcomes were collected. PETCT scans were evaluated using the IMPeTUs criteria, focusing on the Deauville 5-point scoring system for bone marrow and lesions. Results The mean age of the cohort was 65 years. Ig G kappa was the most common MM type 37.1. Diffuse bone marrow uptake and focal lesions were observed in 37.2 and 57.2 of patients, respectively, DS  4. The PET score cut-off of 6.5 predicted PFS with 61.5 sensitivity and 72.7 specificity AUC 0.715. Median PFS was significantly different between patients with PET score  6.5 and  6.5 35  4.1 months vs. 23.6  4.03 months, p  0.027. Conclusions The PET score cut-off value of 6.5 serves as a potential prognostic tool for MM, aiding in patient stratification and treatment decisions.

 Aim Multiple myeloma MM is a clonal plasma cell malignancy that infiltrates the bone marrow, bone, and sometimes extramedullary sites. Reliable staging and prognostic factors are essential for patient management. Imaging modalities, especially 18FFDG PETCT, are essential for the assessment of disease extent. This study evaluates a scoring system based on the IMPeTUs criteria for predicting progression-free survival PFS in MM. Materials and Methods This study included 35 newly diagnosed, treatment-naive MM patients 13 females, 22 males. Baseline 18FFDG PETCT scans were obtained within one month of diagnosis. Data on MM type, ISS stage, chemotherapy regimens and outcomes were collected. PETCT scans were evaluated using the IMPeTUs criteria, focusing on the Deauville 5-point scoring system for bone marrow and lesions. Results The mean age of the cohort was 65 years. Ig G kappa was the most common MM type 37.1. Diffuse bone marrow uptake and focal lesions were observed in 37.2 and 57.2 of patients, respectively, DS  4. The PET score cut-off of 6.5 predicted PFS with 61.5 sensitivity and 72.7 specificity AUC 0.715. Median PFS was significantly different between patients with PET score  6.5 and  6.5 35  4.1 months vs. 23.6  4.03 months, p  0.027. Conclusions The PET score cut-off value of 6.5 serves as a potential prognostic tool for MM, aiding in patient stratification and treatment decisions.

 Amaç Multipl myelom MM, kemik iliği, kemik ve bazen ekstramedüller bölgeleri infiltre eden klonal bir plazma hücre malignitesidir. Hastaların yönetimi için güvenilir evreleme ve prognostik faktörler gereklidir. Görüntüleme yöntemleri, özellikle 18FFDG PETBT, hastalığın yaygınlığını değerlendirmede kritik rol oynar. Bu çalışma, MMde progresyonsuz sağkalımı PFS öngörmek için IMPeTUS kriterlerine dayalı bir puanlama sistemini değerlendirmektedir. Gereç ve Yöntemler Bu çalışmaya, yeni tanı almış ve tedavi edilmemiş 35 MM hastası 13 kadın, 22 erkek dahil edilmiştir. Tanıdan sonraki bir ay içinde hastalara başlangıç 18FFDG PETBT taramaları yapılmıştır. MM tipi, ISS evresi, kemoterapi rejimleri ve hasta sonuçlarına ilişkin veriler toplanmıştır. PETBT görüntüleri IMPeTUS kriterlerine göre değerlendirilmiş ve özellikle kemik iliği ile lezyonlar için Deauville 5 puanlı skorlama sistemi kullanılmıştır. Bulgular Kohortun ortalama yaşı 65 idi. En yaygın MM tipi Ig G kappa olarak saptandı 37.1. Difüz kemik iliği tutulumu ve fokal lezyonlar sırasıyla hastaların 37.2 ve 57.2sinde gözlendi DS  4. PET skoru için 6.5 eşik değeri, PFSyi 61.5 duyarlılık ve 72.7 özgüllükle öngördü EAA: 0.715. PET skoru  6.5 olan hastalar ile  6.5 olan hastalar arasında ortanca PFS açısından anlamlı fark bulundu 35  4.1 ay vs. 23.6  4.03 ay, p  0.027. Sonuçlar PET skoru için belirlenen 6.5 eşik değeri, MMde prognostik bir belirteç olarak kullanılabilir ve hasta sınıflandırması ile tedavi kararlarına katkı sağlayabilir.

Makale detayları

Prognostic importance of PET score obtained from IMPeTUS criteria in multiple myeloma

Yazarlar:

Özlem Beyler | İhsan Kaplan | Cengiz Demir | Canan Can | Halil Kömek

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Nükleer Tıp | Hematolojik Tümörler

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 3, pp.430-434

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349466

pISSN:

2636-8579

Multiple Myeloma

PET score

IMPeTUS criteria

DeauvilleAnahtar Kelimeler: Multipl Myelom

PET skoru

IMPeTUS kriterleri

Deauville

Sayı

Makale detayları

Yazarlar: Özlem Beyler | İhsan Kaplan | Cengiz Demir | Canan Can | Halil Kömek

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Nükleer Tıp | Hematolojik Tümörler

Dergi: Journal of Health Sciences and Medicine Vol.8 Issue 3, pp.430-434

Belge Tipi: Makale

Yayın Tarihi: 5/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001349466

pISSN: 2636-8579

Sayı

Yazarlar:

Özlem Beyler | İhsan Kaplan | Cengiz Demir | Canan Can | Halil Kömek

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Nükleer Tıp | Hematolojik Tümörler

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 3, pp.430-434

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349466

pISSN:

2636-8579