The Effect of Antidepressant Use on Weight Loss After One Anastomosis Gastric Bypass: A Retrospective Cohort Study

Recep Aktimur; Arda Kazım Demirkan

Makale detayları

The Effect of Antidepressant Use on Weight Loss After One Anastomosis Gastric Bypass: A Retrospective Cohort Study

Yazarlar:

Recep Aktimur | Arda Kazım Demirkan

Yayıncı:

Hitit University

Ana Başlıklar:

Genel Cerrahi | Psikiyatri

Dergi:

Hitit Medical Journal Vol.7 Issue 3, pp.432-441

Belge Tipi:

Makale

Yayın Tarihi:

10/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001360233

pISSN:

2687-4717

Anahtar kelimeler:

Özet:

 Objective: Antidepressant use is frequently associated with weight gain, yet little is known about its impact on postoperative weight loss following bariatric surgery. This study aimed to examine how antidepressant usebefore andor after surgeryaffects weight loss outcomes in patients undergoing one-anastomosis gastric bypass OAGB. Material and Method: This retrospective cohort study included 181 patients who underwent OAGB between January 2020 and December 2021. Based on antidepressant use, patients were categorized into four groups: no use n87, preoperative use only n25, continued use before and after surgery n36, and new initiation after surgery n33. Weight loss outcomes were assessed using percentage of excess BMI loss EBMIL and total weight loss TWL at 12 months postoperatively. Statistical comparisons were conducted using independent samples t-tests. Results: There were no significant differences in TWL between any of the groups range: 34.5437.05. However, EBMIL was significantly lower in the continued-use group 82.21 compared to the no-use group p0.0270 and the preoperative-use-only group p0.0196. No statistically significant differences were found between other groups. Demographic variables were generally comparable, though hypertension, hyperlipidemia, and gender distribution differed significantly across groups. Conclusion: Continued antidepressant use after OAGB may negatively affect EBMIL, despite similar TWL outcomes. These findings suggest that antidepressant exposure, particularly when continued into the postoperative period, may attenuate the optimal metabolic benefits of bariatric surgery. Future prospective studies with pharmacokinetic monitoring and larger samples are warranted to clarify medication-specific effects.

 Objective: Antidepressant use is frequently associated with weight gain, yet little is known about its impact on postoperative weight loss following bariatric surgery. This study aimed to examine how antidepressant usebefore andor after surgeryaffects weight loss outcomes in patients undergoing one-anastomosis gastric bypass OAGB. Material and Method: This retrospective cohort study included 181 patients who underwent OAGB between January 2020 and December 2021. Based on antidepressant use, patients were categorized into four groups: no use n87, preoperative use only n25, continued use before and after surgery n36, and new initiation after surgery n33. Weight loss outcomes were assessed using percentage of excess BMI loss EBMIL and total weight loss TWL at 12 months postoperatively. Statistical comparisons were conducted using independent samples t-tests. Results: There were no significant differences in TWL between any of the groups range: 34.5437.05. However, EBMIL was significantly lower in the continued-use group 82.21 compared to the no-use group p0.0270 and the preoperative-use-only group p0.0196. No statistically significant differences were found between other groups. Demographic variables were generally comparable, though hypertension, hyperlipidemia, and gender distribution differed significantly across groups. Conclusion: Continued antidepressant use after OAGB may negatively affect EBMIL, despite similar TWL outcomes. These findings suggest that antidepressant exposure, particularly when continued into the postoperative period, may attenuate the optimal metabolic benefits of bariatric surgery. Future prospective studies with pharmacokinetic monitoring and larger samples are warranted to clarify medication-specific effects.

 Objective: Antidepressant use is frequently associated with weight gain, yet little is known about its impact on postoperative weight loss following bariatric surgery. This study aimed to examine how antidepressant usebefore andor after surgeryaffects weight loss outcomes in patients undergoing one-anastomosis gastric bypass OAGB. Material and Method: This retrospective cohort study included 181 patients who underwent OAGB between January 2020 and December 2021. Based on antidepressant use, patients were categorized into four groups: no use n87, preoperative use only n25, continued use before and after surgery n36, and new initiation after surgery n33. Weight loss outcomes were assessed using percentage of excess BMI loss EBMIL and total weight loss TWL at 12 months postoperatively. Statistical comparisons were conducted using independent samples t-tests. Results: There were no significant differences in TWL between any of the groups range: 34.5437.05. However, EBMIL was significantly lower in the continued-use group 82.21 compared to the no-use group p0.0270 and the preoperative-use-only group p0.0196. No statistically significant differences were found between other groups. Demographic variables were generally comparable, though hypertension, hyperlipidemia, and gender distribution differed significantly across groups. Conclusion: Continued antidepressant use after OAGB may negatively affect EBMIL, despite similar TWL outcomes. These findings suggest that antidepressant exposure, particularly when continued into the postoperative period, may attenuate the optimal metabolic benefits of bariatric surgery. Future prospective studies with pharmacokinetic monitoring and larger samples are warranted to clarify medication-specific effects.

 Amaç: Antidepresan kullanımı genellikle kilo alımıyla ilişkilendirilmekte olup, bariatrik cerrahi sonrası kilo kaybı üzerindeki etkisi hakkında ise sınırlı bilgi mevcuttur. Bu çalışmada, ameliyat öncesi veveya sonrası antidepresan kullanımının, tek anastomozlu gastrik bypass OAGB geçiren hastalardaki kilo kaybı sonuçlarına etkisi incelenmiştir. Gereç ve Yöntem: Bu retrospektif kohort çalışmasına, Ocak 2020 ile Aralık 2021 tarihleri arasında OAGB ameliyatı geçiren 181 hasta dahil edilmiştir. Hastalar antidepresan kullanımına göre dört gruba ayrılmıştır: hiç kullanmayanlar n87, sadece ameliyat öncesi kullananlar n25, ameliyat öncesi ve sonrasında kullanmaya devam edenler n36, ve sadece ameliyat sonrası başlayanlar n33. Kilo kaybı sonuçları, ameliyattan 12 ay sonra ölçülen vücut kitle indeksi fazlalığı kaybı yüzdesi EBMIL ve toplam kilo kaybı yüzdesi TWL ile değerlendirilmiştir. İstatistiksel karşılaştırmalar bağımsız örneklem t-testi ile yapılmıştır. Bulgular: Gruplar arasında TWL açısından anlamlı bir fark saptanmamıştır aralık: 34,5437.05. Ancak, EBMIL değeri, antidepresan kullanımını sürdüren grupta 82,21, hiç kullanmayan gruba p0.0270 ve sadece preoperatif kullanan gruba p0.0196 kıyasla anlamlı derecede daha düşüktü. Diğer gruplar arasında istatistiksel olarak anlamlı fark bulunmamıştır. Demografik değişkenler genel olarak benzerdi; ancak hipertansiyon, hiperlipidemi ve cinsiyet dağılımı gruplar arasında anlamlı farklılık göstermekteydi. Sonuç: OAGB sonrası antidepresan kullanımının devam etmesi, EBMIL üzerinde olumsuz bir etki yaratabilir; bu durum TWL sonuçlarının benzer olmasına rağmen geçerlidir. Bu bulgular, antidepresan maruziyetininözellikle postoperatif dönemde sürdüğündebariatrik cerrahinin optimal metabolik faydalarını azaltabileceğini düşündürmektedir. İlaçlara özgü etkilerin netleştirilebilmesi için farmakokinetik izlemi içeren ve daha geniş örneklemlerle yapılacak prospektif çalışmalara ihtiyaç vardır.

Makale detayları

The Effect of Antidepressant Use on Weight Loss After One Anastomosis Gastric Bypass: A Retrospective Cohort Study

Yazarlar:

Recep Aktimur | Arda Kazım Demirkan

Yayıncı:

Hitit University

Ana Başlıklar:

Genel Cerrahi | Psikiyatri

Dergi:

Hitit Medical Journal Vol.7 Issue 3, pp.432-441

Belge Tipi:

Makale

Yayın Tarihi:

10/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001360233

pISSN:

2687-4717

antidepressants

bariatric surgery

OAGB

weight loss

%EBMIL

%TWLantidepresanlar

bariatrik cerrahi

kilo kaybı

OAGB

%EBMIL

%TWL

Sayı

Makale detayları

Yazarlar: Recep Aktimur | Arda Kazım Demirkan

Yayıncı: Hitit University

Ana Başlıklar: Genel Cerrahi | Psikiyatri

Dergi: Hitit Medical Journal Vol.7 Issue 3, pp.432-441

Belge Tipi: Makale

Yayın Tarihi: 10/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001360233

pISSN: 2687-4717

Sayı

Yazarlar:

Recep Aktimur | Arda Kazım Demirkan

Yayıncı:

Hitit University

Ana Başlıklar:

Genel Cerrahi | Psikiyatri

Dergi:

Hitit Medical Journal Vol.7 Issue 3, pp.432-441

Belge Tipi:

Makale

Yayın Tarihi:

10/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001360233

pISSN:

2687-4717