Serum soluble alpha klotho and periostin as a biomarker for detection of early diabetic nephropathy in Iraqi male with Type 2 Diabetes

N.A.

Makale detayları

Serum soluble alpha klotho and periostin as a biomarker for detection of early diabetic nephropathy in Iraqi male with Type 2 Diabetes

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 5, pp.1665-1673

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347607

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Diabetic nephropathy DN is one of the most prevalent diabetic microvascular complications, affecting up to 40 of type 2 diabetic patients T2DM and represents a general reason of chronic kidney disorder and end-stage kidney disease ESKD. This study aimed to evaluate the soluble alpha klotho and periostin POSTN role as predictor of diabetic- nephropathy DN on 120 patients, 60 with T2DM and 60 with DN under hemodialysis DN-HD in a cross-sectional study. Serum-soluble alpha-klotho and periostin levels were evaluated using ELISA techniques. Receiver operating characteristic curves were used to evaluate the predictive value of soluble alpha-klotho and periostin, which revealed that soluble alpha-klotho significantly decreased in DN-HD patients compared to T2DM patients, while periostin significantly increased in DN-HD patients in comparison with T2DM patients. Specificity and sensitivity of the soluble alpha klotho in predicting DN were 62 and 59, at cut-off value was 98.63 ngmL, while periostins sensitivity and specificity were 92 and 90 at a cut-off value of 238.17 ngmL which indicate that serum periostin can be considered as a valuable biomarker for early detection of DN in T2DM patients.

 Diabetic nephropathy DN is one of the most prevalent diabetic microvascular complications, affecting up to 40 of type 2 diabetic patients T2DM and represents a general reason of chronic kidney disorder and end-stage kidney disease ESKD. This study aimed to evaluate the soluble alpha klotho and periostin POSTN role as predictor of diabetic- nephropathy DN on 120 patients, 60 with T2DM and 60 with DN under hemodialysis DN-HD in a cross-sectional study. Serum-soluble alpha-klotho and periostin levels were evaluated using ELISA techniques. Receiver operating characteristic curves were used to evaluate the predictive value of soluble alpha-klotho and periostin, which revealed that soluble alpha-klotho significantly decreased in DN-HD patients compared to T2DM patients, while periostin significantly increased in DN-HD patients in comparison with T2DM patients. Specificity and sensitivity of the soluble alpha klotho in predicting DN were 62 and 59, at cut-off value was 98.63 ngmL, while periostins sensitivity and specificity were 92 and 90 at a cut-off value of 238.17 ngmL which indicate that serum periostin can be considered as a valuable biomarker for early detection of DN in T2DM patients.

 Diabetic nephropathy DN is one of the most prevalent diabetic microvascular complications, affecting up to 40 of type 2 diabetic patients T2DM and represents a general reason of chronic kidney disorder and end-stage kidney disease ESKD. This study aimed to evaluate the soluble alpha klotho and periostin POSTN role as predictor of diabetic- nephropathy DN on 120 patients, 60 with T2DM and 60 with DN under hemodialysis DN-HD in a cross-sectional study. Serum-soluble alpha-klotho and periostin levels were evaluated using ELISA techniques. Receiver operating characteristic curves were used to evaluate the predictive value of soluble alpha-klotho and periostin, which revealed that soluble alpha-klotho significantly decreased in DN-HD patients compared to T2DM patients, while periostin significantly increased in DN-HD patients in comparison with T2DM patients. Specificity and sensitivity of the soluble alpha klotho in predicting DN were 62 and 59, at cut-off value was 98.63 ngmL, while periostins sensitivity and specificity were 92 and 90 at a cut-off value of 238.17 ngmL which indicate that serum periostin can be considered as a valuable biomarker for early detection of DN in T2DM patients.

 Diabetic nephropathy DN is one of the most prevalent diabetic microvascular complications, affecting up to 40 of type 2 diabetic patients T2DM and represents a general reason of chronic kidney disorder and end-stage kidney disease ESKD. This study aimed to evaluate the soluble alpha klotho and periostin POSTN role as predictor of diabetic- nephropathy DN on 120 patients, 60 with T2DM and 60 with DN under hemodialysis DN-HD in a cross-sectional study. Serum-soluble alpha-klotho and periostin levels were evaluated using ELISA techniques. Receiver operating characteristic curves were used to evaluate the predictive value of soluble alpha-klotho and periostin, which revealed that soluble alpha-klotho significantly decreased in DN-HD patients compared to T2DM patients, while periostin significantly increased in DN-HD patients in comparison with T2DM patients. Specificity and sensitivity of the soluble alpha klotho in predicting DN were 62 and 59, at cut-off value was 98.63 ngmL, while periostins sensitivity and specificity were 92 and 90 at a cut-off value of 238.17 ngmL which indicate that serum periostin can be considered as a valuable biomarker for early detection of DN in T2DM patients.

Makale detayları

Serum soluble alpha klotho and periostin as a biomarker for detection of early diabetic nephropathy in Iraqi male with Type 2 Diabetes

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 5, pp.1665-1673

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347607

pISSN:

2630-6344

Diabetic mellitus

Diabetic-nephropathy

soluble alpha klotho

periostin

Sayı

Makale detayları

Serum soluble alpha klotho and periostin as a biomarker for detection of early diabetic nephropathy in Iraqi male with Type 2 Diabetes

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Chemistry

Dergi: Journal of Research in Pharmacy Vol.28 Issue 5, pp.1665-1673

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347607

pISSN: 2630-6344

Diabetic mellitus

Diabetic-nephropathy

soluble alpha klotho

periostin

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 5, pp.1665-1673

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347607

pISSN:

2630-6344