The Relationship Between Pathological Findings of Minor Salivary Gland Biopsy Performed at the Time of Diagnosis and Schirmer Test and Serological Tests in Patients with primary Sjögren's Syndrome

Osman Cüre; Oğuzhan Okcu; Bayram Kızılkaya; Mehmet Serhat Topaloğlu; Serdar Durak

Makale detayları

The Relationship Between Pathological Findings of Minor Salivary Gland Biopsy Performed at the Time of Diagnosis and Schirmer Test and Serological Tests in Patients with primary Sjögren's Syndrome

Yazarlar:

Osman Cüre | Oğuzhan Okcu | Bayram Kızılkaya | Mehmet Serhat Topaloğlu | Serdar Durak

Yayıncı:

Manisa Celal Bayar University

Ana Başlıklar:

Romatoloji ve Artrit

Dergi:

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.12 Issue 1, pp.117-124

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343449

pISSN:

2147-9607

Anahtar kelimeler:

Özet:

 Aim Our aim was to assess the correlation between minor salivary gland pathology and the results of Schirmer and serological tests conducted during the diagnosis of primary Sjögrens syndrome pSS. Method A total of 41 patients who were diagnosed with pSS after having serological tests, minor salivary gland biopsy and Schirmer test performed at our institution at the time of diagnosis between June 2018 and July 2023 were included in the study. Focus score, atrophy and fibrosis values were scored in biopsy samples. The relationship between histopathological findings and clinical, Schirmer test and serological tests was evaluated. Results Of the 41 patients, 38 were female 92.7, 3 7 were male, and the average age was 55.54  14.06. In patients with focal score1, antinuclear antibody value1320 42.9, rheumatoid factor positivity 28.6, anti Sjögrens syndrome SS ASSB positivity 76.2, 38.1  was detected at a higher rate. Additionally, acinar atrophy and fibrosis were higher in patients with focus score1, and there was a significant relationship between fibrosis p0.008. A significant correlation was detected between age with acinar atrophy and fibrosis score1 p0.030, p0.006 and between dry mouth with fibrosis p0.008. In multivariate analysis, schimer test positivity in focal score was observed as an independent risk factor OR  22.531, 95CI 1.369370.174. Conclusion In our study, a high focus score was found to be correlated with positive serological tests and impaired exocrine functions, and a positive Schirmer test was found to have an increasing effect on the focus score.

 Aim Our aim was to assess the correlation between minor salivary gland pathology and the results of Schirmer and serological tests conducted during the diagnosis of primary Sjögrens syndrome pSS. Method A total of 41 patients who were diagnosed with pSS after having serological tests, minor salivary gland biopsy and Schirmer test performed at our institution at the time of diagnosis between June 2018 and July 2023 were included in the study. Focus score, atrophy and fibrosis values were scored in biopsy samples. The relationship between histopathological findings and clinical, Schirmer test and serological tests was evaluated. Results Of the 41 patients, 38 were female 92.7, 3 7 were male, and the average age was 55.54  14.06. In patients with focal score1, antinuclear antibody value1320 42.9, rheumatoid factor positivity 28.6, anti Sjögrens syndrome SS ASSB positivity 76.2, 38.1  was detected at a higher rate. Additionally, acinar atrophy and fibrosis were higher in patients with focus score1, and there was a significant relationship between fibrosis p0.008. A significant correlation was detected between age with acinar atrophy and fibrosis score1 p0.030, p0.006 and between dry mouth with fibrosis p0.008. In multivariate analysis, schimer test positivity in focal score was observed as an independent risk factor OR  22.531, 95CI 1.369370.174. Conclusion In our study, a high focus score was found to be correlated with positive serological tests and impaired exocrine functions, and a positive Schirmer test was found to have an increasing effect on the focus score.

 Aim Our aim was to assess the correlation between minor salivary gland pathology and the results of Schirmer and serological tests conducted during the diagnosis of primary Sjögrens syndrome pSS. Method A total of 41 patients who were diagnosed with pSS after having serological tests, minor salivary gland biopsy and Schirmer test performed at our institution at the time of diagnosis between June 2018 and July 2023 were included in the study. Focus score, atrophy and fibrosis values were scored in biopsy samples. The relationship between histopathological findings and clinical, Schirmer test and serological tests was evaluated. Results Of the 41 patients, 38 were female 92.7, 3 7 were male, and the average age was 55.54  14.06. In patients with focal score1, antinuclear antibody value1320 42.9, rheumatoid factor positivity 28.6, anti Sjögrens syndrome SS ASSB positivity 76.2, 38.1  was detected at a higher rate. Additionally, acinar atrophy and fibrosis were higher in patients with focus score1, and there was a significant relationship between fibrosis p0.008. A significant correlation was detected between age with acinar atrophy and fibrosis score1 p0.030, p0.006 and between dry mouth with fibrosis p0.008. In multivariate analysis, schimer test positivity in focal score was observed as an independent risk factor OR  22.531, 95CI 1.369370.174. Conclusion In our study, a high focus score was found to be correlated with positive serological tests and impaired exocrine functions, and a positive Schirmer test was found to have an increasing effect on the focus score.

 Giriş ve Amaç Primer Sjögren sendromlu pSS hastalarda tanı anında yapılan minör tükrük bezi patolojisi ile schirmer testi ve serolojik test sonuçları arasındaki ilişkiyi değerlendirmeyi amaçladık. Gereç ve Yöntemler Haziran 2018-Temmuz 2023 tarihleri arasında tanı anında kurumumuzda serolojik testleri, minör tükürük bezi biyopsisi ve schirmer testi yapılıp pSS tanısı alan toplam 41 hasta çalışmaya dahil edildi. Biyopsi örneklerinde odak skoru, atrofi ve fibrozis değerleri skorlandı. Histopatolojik bulgular ile demografik, klinik, schirmer testi ve serolojik testler arasındaki ilişki değerlendirildi. Bulgular 41 hastanın 38i 92,7 kadın, 3ü 7 erkek olup yaş ortalaması 55,5414,06 idi. Fokus skoru1 olan hastalarda; antinükleer antikor değeri1320 42,9, romatoid faktör pozitifliği 28,6, anti Sjögren sendromu SS ASSB pozitifliği 76,2, 38,1 daha yüksek oranda saptandı. Ayrıca, fokus skoru1 olan hastalarda asiner atrofi ve fibrozis daha yüksek olmakla fibrozisle arasında anlamlı ilişki vardı p0.008. Yaş ile asiner atrofi ve fibrozis skoru1 arasında p0,030, p0,006 ve ağız kuruluğu ile fibrozis arasında p0,008 anlamlı korelasyon saptandı. Çok değişkenli analizde fokus skorunda schimer testi pozitifliği bağımsız bir risk faktörü olarak gözlendi OR  22,531, 95CI 1,369370,174. Sonuç Çalışmamızda yüksek fokus skorunun serolojik testlerin pozitifliği ve ekzokrin fonksiyonların bozulmasıyla ilişkili olduğu, Schirmer testinin pozitif olmasının fokus skorunu artırıcı etkisi olduğu belirlendi.

Makale detayları

The Relationship Between Pathological Findings of Minor Salivary Gland Biopsy Performed at the Time of Diagnosis and Schirmer Test and Serological Tests in Patients with primary Sjögren's Syndrome

Yazarlar:

Osman Cüre | Oğuzhan Okcu | Bayram Kızılkaya | Mehmet Serhat Topaloğlu | Serdar Durak

Yayıncı:

Manisa Celal Bayar University

Ana Başlıklar:

Romatoloji ve Artrit

Dergi:

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.12 Issue 1, pp.117-124

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343449

pISSN:

2147-9607

Minör tükürük bezi biyopsisi

Serolojik Testler

Schirmer testi

Sjögren sendromuMinör tükürük bezi biyopsisi

Serolojik Testler

Schirmer testi

Sjögren sendromu

Sayı

Makale detayları

Yazarlar: Osman Cüre | Oğuzhan Okcu | Bayram Kızılkaya | Mehmet Serhat Topaloğlu | Serdar Durak

Yayıncı: Manisa Celal Bayar University

Ana Başlıklar: Romatoloji ve Artrit

Dergi: Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.12 Issue 1, pp.117-124

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001343449

pISSN: 2147-9607

Sayı

Yazarlar:

Osman Cüre | Oğuzhan Okcu | Bayram Kızılkaya | Mehmet Serhat Topaloğlu | Serdar Durak

Yayıncı:

Manisa Celal Bayar University

Ana Başlıklar:

Romatoloji ve Artrit

Dergi:

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.12 Issue 1, pp.117-124

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343449

pISSN:

2147-9607