Development and evaluation of a pH triggered in situ ocular gel of brimonidine tartrate

N.A.

Makale detayları

Development and evaluation of a pH triggered in situ ocular gel of brimonidine tartrate

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 3, pp.416-424

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347177

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The aim of the present research work was to prepare and evaluate in situ gel forming ophthalmic drug delivery system loaded with brimonidine tartarate BT. In this work, carbopol and hydroxy propyl methyl cellulose HPMC, ophthalmic gel-forming mucoadhesive polymers, which gets converted to gel in the lachrymal fluid were used as in the preparation of pH t riggered in situ gel formulation. The formulations were then autoclaved at 121C for 15 min and evaluated for pH, clarity, gelling capacity, drug content, viscosity, and in vitro release. The developed formulations exhibited extended release of drug over a period of 8 hours in in vitro studies and therefore it could increase the residence time in eye. The optimized formulations were finally tested for its ability to cause irritation in male albino rabbits. The results indicated that the formulations did not irritate or damage the cornea, iris and conjunctiva.

 The aim of the present research work was to prepare and evaluate in situ gel forming ophthalmic drug delivery system loaded with brimonidine tartarate BT. In this work, carbopol and hydroxy propyl methyl cellulose HPMC, ophthalmic gel-forming mucoadhesive polymers, which gets converted to gel in the lachrymal fluid were used as in the preparation of pH t riggered in situ gel formulation. The formulations were then autoclaved at 121C for 15 min and evaluated for pH, clarity, gelling capacity, drug content, viscosity, and in vitro release. The developed formulations exhibited extended release of drug over a period of 8 hours in in vitro studies and therefore it could increase the residence time in eye. The optimized formulations were finally tested for its ability to cause irritation in male albino rabbits. The results indicated that the formulations did not irritate or damage the cornea, iris and conjunctiva.

 The aim of the present research work was to prepare and evaluate in situ gel forming ophthalmic drug delivery system loaded with brimonidine tartarate BT. In this work, carbopol and hydroxy propyl methyl cellulose HPMC, ophthalmic gel-forming mucoadhesive polymers, which gets converted to gel in the lachrymal fluid were used as in the preparation of pH t riggered in situ gel formulation. The formulations were then autoclaved at 121C for 15 min and evaluated for pH, clarity, gelling capacity, drug content, viscosity, and in vitro release. The developed formulations exhibited extended release of drug over a period of 8 hours in in vitro studies and therefore it could increase the residence time in eye. The optimized formulations were finally tested for its ability to cause irritation in male albino rabbits. The results indicated that the formulations did not irritate or damage the cornea, iris and conjunctiva.

 The aim of the present research work was to prepare and evaluate in situ gel forming ophthalmic drug delivery system loaded with brimonidine tartarate BT. In this work, carbopol and hydroxy propyl methyl cellulose HPMC, ophthalmic gel-forming mucoadhesive polymers, which gets converted to gel in the lachrymal fluid were used as in the preparation of pH t riggered in situ gel formulation. The formulations were then autoclaved at 121C for 15 min and evaluated for pH, clarity, gelling capacity, drug content, viscosity, and in vitro release. The developed formulations exhibited extended release of drug over a period of 8 hours in in vitro studies and therefore it could increase the residence time in eye. The optimized formulations were finally tested for its ability to cause irritation in male albino rabbits. The results indicated that the formulations did not irritate or damage the cornea, iris and conjunctiva.

Makale detayları

Development and evaluation of a pH triggered in situ ocular gel of brimonidine tartrate

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 3, pp.416-424

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347177

pISSN:

2630-6344

Brimonidine tartarate

in situ gel

ophthalmic drug delivery

viscosity enhancemen

in vitro release

Sayı

Makale detayları

Development and evaluation of a pH triggered in situ ocular gel of brimonidine tartrate

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.24 Issue 3, pp.416-424

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347177

pISSN: 2630-6344

Brimonidine tartarate

in situ gel

ophthalmic drug delivery

viscosity enhancemen

in vitro release

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 3, pp.416-424

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347177

pISSN:

2630-6344