Synthesis of two 7,8-dioxabicyclo[4.1.1]octan-3-yl)-steroid derivatives and evaluation of  their inotropic activity in an animal model.

Figueroa LAURO; Lopez MARIA; Diaz FRANCISCO; Rosas MARCELA; Mateu VIRGINIA; Garcimarrero ALEJANDRA; Borges YARITZA

doi:https://doi.org/10.15671/hjbc.602029

Makale detayları

Synthesis of two 7,8-dioxabicyclo[4.1.1]octan-3-yl)-steroid derivatives and evaluation of their inotropic activity in an animal model.

Yazarlar:

Figueroa LAURO | Lopez MARIA | Diaz FRANCISCO | Rosas MARCELA | Mateu VIRGINIA | Garcimarrero ALEJANDRA | Borges YARITZA

Yayıncı:

Hacettepe University

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Hacettepe Journal of Biology and Chemistry 2020 Vol.48 Issue 1, pp.1-12

Belge Tipi:

Makale

Yayın Tarihi:

4/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000448302

Sıklık:

Üç Aylık

eISSN:

2687-475X

pISSN:

2687-475X

DOI:

https://doi.org/10.15671/hjbc.602029

Özet:

 


 

The aim of this study was synthesizing two 7,8-dioxabicyclo[4.1.1]octan-3-yl)-steroid derivatives (compounds 3 or 4) to evaluate their inotropic activity in vitro. The first stage was achieved by the preparation of two 7,8-dioxabicyclo[4.1.1]octan-3-yl)-steroid derivatives using some chemical strategies. Then, the inotropic activity of both steroid derivatives against left ventricular pressure (LVP) was evaluated in an isolated rat heart model using Bay-k-8644, nifedipine, aucubin, and L-NAME as controls. The results showed that compound 3 increased LVP in a dose-dependent manner and this effect was inhibited by nifedipine. Other results showed that compound 4 decreased LVP in a dose-dependent manner and this effect was blocked in the presence of L-NAME. All these data indicate that 1) the positive inotropic activity exerted by compound 3 was through type L calcium channel activation; 2) the negative inotropic effect of 4 was via nitric oxide synthase activation. These phenomena could be due to the different functional groups involved in the chemical structure of compounds 3 and 4.




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Makale detayları

Synthesis of two 7,8-dioxabicyclo[4.1.1]octan-3-yl)-steroid derivatives and evaluation of their inotropic activity in an animal model.

Yazarlar: Figueroa LAURO | Lopez MARIA | Diaz FRANCISCO | Rosas MARCELA | Mateu VIRGINIA | Garcimarrero ALEJANDRA | Borges YARITZA

Yayıncı: Hacettepe University

Ana Başlıklar: Uygulamalı fizik

Dergi: Hacettepe Journal of Biology and Chemistry 2020 Vol.48 Issue 1, pp.1-12

Belge Tipi: Makale

Yayın Tarihi: 4/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000448302

Sıklık: Üç Aylık

eISSN: 2687-475X

pISSN: 2687-475X

DOI: https://doi.org/10.15671/hjbc.602029

Sayı

Yazarlar:

Figueroa LAURO | Lopez MARIA | Diaz FRANCISCO | Rosas MARCELA | Mateu VIRGINIA | Garcimarrero ALEJANDRA | Borges YARITZA

Yayıncı:

Hacettepe University

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Hacettepe Journal of Biology and Chemistry 2020 Vol.48 Issue 1, pp.1-12

Belge Tipi:

Makale

Yayın Tarihi:

4/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000448302

Sıklık:

Üç Aylık

eISSN:

2687-475X

pISSN:

2687-475X

DOI:

https://doi.org/10.15671/hjbc.602029