Production of (S)-(-)-1-(1´-Napthyl) Ethanol by Rhodotorula glutinis Isolate Using Ram Horn Peptone

Esabi B. KURBANOĞLU; Kani ZİLBEYAZ; Namudar I. KURBANOĞLU

Makale detayları

Production of (S)-(-)-1-(1´-Napthyl) Ethanol by Rhodotorula glutinis Isolate Using Ram Horn Peptone

Yazarlar:

Esabi B. KURBANOĞLU | Kani ZİLBEYAZ | Namudar I. KURBANOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2008 Vol.32 Issue 6, pp.685-692

Belge Tipi:

Makale

Yayın Tarihi:

5/2008

Belge Dili:

Türkçe

Document ID (Org No.):

2000728396

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

The bioreduction of 1-acetonaphthone 1 by locally isolated  Rhodotorula glutinis strains using ram horn peptone (RHP) gave  (S)-(-)-1-(1´-naphthyl) ethanol (2), an important pharmaceutical  intermediate.  R. glutinis strains were isolated from the water of  fermented Salix leaves.  Optimum fermentation conditions for the  production of 2 were 200 rpm, 32 °C, and pH 6.5.  The production of 2  with excellent enantiomeric excess (>99%), and good conversion  (100%) and yield (78%) under optimum conditions was achieved up to  preparative scale via a fermenter.  Wide temperature, pH, time, and  agitation ranges did not affect the enantiomeric excess (ee) of the  bioreduction product.  A simple process for the isolation of R.  glutinis was also developed.

 

The bioreduction of 1-acetonaphthone 1 by locally isolated  Rhodotorula glutinis strains using ram horn peptone (RHP) gave  (S)-(-)-1-(1´-naphthyl) ethanol (2), an important pharmaceutical  intermediate.  R. glutinis strains were isolated from the water of  fermented Salix leaves.  Optimum fermentation conditions for the  production of 2 were 200 rpm, 32 °C, and pH 6.5.  The production of 2  with excellent enantiomeric excess (>99%), and good conversion  (100%) and yield (78%) under optimum conditions was achieved up to  preparative scale via a fermenter.  Wide temperature, pH, time, and  agitation ranges did not affect the enantiomeric excess (ee) of the  bioreduction product.  A simple process for the isolation of R.  glutinis was also developed.

Makale detayları

Production of (S)-(-)-1-(1´-Napthyl) Ethanol by Rhodotorula glutinis Isolate Using Ram Horn Peptone

Yazarlar: Esabi B. KURBANOĞLU | Kani ZİLBEYAZ | Namudar I. KURBANOĞLU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2008 Vol.32 Issue 6, pp.685-692

Belge Tipi: Makale

Yayın Tarihi: 5/2008

Belge Dili: Türkçe

Document ID (Org No.): 2000728396

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Esabi B. KURBANOĞLU | Kani ZİLBEYAZ | Namudar I. KURBANOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2008 Vol.32 Issue 6, pp.685-692

Belge Tipi:

Makale

Yayın Tarihi:

5/2008

Belge Dili:

Türkçe

Document ID (Org No.):

2000728396

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527