Physicochemical Effects of PEG Content in Alginate-based Double Network Hydrogels as Hybrid Scaffolds

Ozgul Gok

Makale detayları

Physicochemical Effects of PEG Content in Alginate-based Double Network Hydrogels as Hybrid Scaffolds

Yazarlar:

Ozgul Gok

Yayıncı:

Fırat University

Ana Başlıklar:

Biomaterial

Dergi:

Turkish Journal of Science and Technology Vol.19 Issue 1, pp.249-256

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001309706

pISSN:

1308-9080

Anahtar kelimeler:

Özet:

 This study aims to prepare a double-network hydrogel as hybrid networks bearing both natural and synthetic polymers to obtain scaffolds with increased swelling capacity and tunable mechanical and morphological properties. Physically cross-linked alginate hydrogel was reinforced with various ratios of Polyethylene glycol PEG polymers which were chemically gellated via UV light exposure with a water soluble initiator. Physicochemical properties of the resulting hydrogels were systematically investigated via Fourier-transform infrared FT-IR spectroscopy for chemical composition and Scanning Electron Microscopy SEM for their morphological features like porosity. Furthermore, the effect of PEG amount in the final hydrogel 10, 20 and 40 on swelling capacity was evaluated as well as the rheological properties. Prepared double-network hydrogels were demonstrated to be composed of both natural alginate polymer and synthetic PEG chains in FT-IR spectrum. Although 10PEG containing hydrogel was not significantly different in terms of swelling capacity from the alginate hydrogel alone, increasing PEG amount seems to have improved the swelling ability. Comparative reological studies presented that introducing covalently cross-linked PEG network into alginate one increased crosspoint of storage and loss moduli almost 12 times more providing a stiffer scaffold. Increasing PEG content decreased the pore size on SEM images, indicating more crosslinking points in hydrogel structure.

 This study aims to prepare a double-network hydrogel as hybrid networks bearing both natural and synthetic polymers to obtain scaffolds with increased swelling capacity and tunable mechanical and morphological properties. Physically cross-linked alginate hydrogel was reinforced with various ratios of Polyethylene glycol PEG polymers which were chemically gellated via UV light exposure with a water soluble initiator. Physicochemical properties of the resulting hydrogels were systematically investigated via Fourier-transform infrared FT-IR spectroscopy for chemical composition and Scanning Electron Microscopy SEM for their morphological features like porosity. Furthermore, the effect of PEG amount in the final hydrogel 10, 20 and 40 on swelling capacity was evaluated as well as the rheological properties. Prepared double-network hydrogels were demonstrated to be composed of both natural alginate polymer and synthetic PEG chains in FT-IR spectrum. Although 10PEG containing hydrogel was not significantly different in terms of swelling capacity from the alginate hydrogel alone, increasing PEG amount seems to have improved the swelling ability. Comparative reological studies presented that introducing covalently cross-linked PEG network into alginate one increased crosspoint of storage and loss moduli almost 12 times more providing a stiffer scaffold. Increasing PEG content decreased the pore size on SEM images, indicating more crosslinking points in hydrogel structure.

 This study aims to prepare a double-network hydrogel as hybrid networks bearing both natural and synthetic polymers to obtain scaffolds with increased swelling capacity and tunable mechanical and morphological properties. Physically cross-linked alginate hydrogel was reinforced with various ratios of Polyethylene glycol PEG polymers which were chemically gellated via UV light exposure with a water soluble initiator. Physicochemical properties of the resulting hydrogels were systematically investigated via Fourier-transform infrared FT-IR spectroscopy for chemical composition and Scanning Electron Microscopy SEM for their morphological features like porosity. Furthermore, the effect of PEG amount in the final hydrogel 10, 20 and 40 on swelling capacity was evaluated as well as the rheological properties. Prepared double-network hydrogels were demonstrated to be composed of both natural alginate polymer and synthetic PEG chains in FT-IR spectrum. Although 10PEG containing hydrogel was not significantly different in terms of swelling capacity from the alginate hydrogel alone, increasing PEG amount seems to have improved the swelling ability. Comparative reological studies presented that introducing covalently cross-linked PEG network into alginate one increased crosspoint of storage and loss moduli almost 12 times more providing a stiffer scaffold. Increasing PEG content decreased the pore size on SEM images, indicating more crosslinking points in hydrogel structure.

 This study aims to prepare a double-network hydrogel as hybrid networks bearing both natural and synthetic polymers to obtain scaffolds with increased swelling capacity and tunable mechanical and morphological properties. Physically cross-linked alginate hydrogel was reinforced with various ratios of Polyethylene glycol PEG polymers which were chemically gellated via UV light exposure with a water soluble initiator. Physicochemical properties of the resulting hydrogels were systematically investigated via Fourier-transform infrared FT-IR spectroscopy for chemical composition and Scanning Electron Microscopy SEM for their morphological features like porosity. Furthermore, the effect of PEG amount in the final hydrogel 10, 20 and 40 on swelling capacity was evaluated as well as the rheological properties. Prepared double-network hydrogels were demonstrated to be composed of both natural alginate polymer and synthetic PEG chains in FT-IR spectrum. Although 10PEG containing hydrogel was not significantly different in terms of swelling capacity from the alginate hydrogel alone, increasing PEG amount seems to have improved the swelling ability. Comparative reological studies presented that introducing covalently cross-linked PEG network into alginate one increased crosspoint of storage and loss moduli almost 12 times more providing a stiffer scaffold. Increasing PEG content decreased the pore size on SEM images, indicating more crosslinking points in hydrogel structure.

Makale detayları

Physicochemical Effects of PEG Content in Alginate-based Double Network Hydrogels as Hybrid Scaffolds

Yazarlar:

Ozgul Gok

Yayıncı:

Fırat University

Ana Başlıklar:

Biomaterial

Dergi:

Turkish Journal of Science and Technology Vol.19 Issue 1, pp.249-256

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001309706

pISSN:

1308-9080

Hybrid Hydrogels

Physical Cross-linking

UV Curing

Porous ScaffoldsHybrid Hydrogels

Physical Cross-linking

UV Curing

Porous Scaffolds

Sayı

Makale detayları

Yazarlar: Ozgul Gok

Yayıncı: Fırat University

Ana Başlıklar: Biomaterial

Dergi: Turkish Journal of Science and Technology Vol.19 Issue 1, pp.249-256

Belge Tipi: Makale

Yayın Tarihi: 3/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001309706

pISSN: 1308-9080

Sayı

Yazarlar:

Ozgul Gok

Yayıncı:

Fırat University

Ana Başlıklar:

Biomaterial

Dergi:

Turkish Journal of Science and Technology Vol.19 Issue 1, pp.249-256

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001309706

pISSN:

1308-9080