The association between monocyte/HDL-C ratio and heart failure

Busra Nur Cattik; Nilay Aksoy; Barkın Berk; Barış Güngör

Makale detayları

The association between monocyte/HDL-C ratio and heart failure

Yazarlar:

Busra Nur Cattik | Nilay Aksoy | Barkın Berk | Barış Güngör

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 3, pp.1089-1097

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344612

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The monocyteHDL-cholesterol ratio MHR was shown to be a marker of inflammation. This study investigated the utilization of this ratio as a measure of severity for heart failure which is a condition associated with inflammation. The MHR was calculated for 323 ambulatory patients with chronic heart failure and compared to other variables associated with the severity of the condition. Additionally, the impact of MHR on the Seattle Heart Failure Model SHFM score was investigated. MHR correlated positively with C-reactive protein r: 0.312, p0.001 and neutrophil-to-lymphocyte ratio r: 0.242, p0.001, but not with platelet-to-lymphocyte ratio. In addition, a correlation was found between the SHFM score and MHR r:-0.267, p0.001. The SHFM score exhibited a significant result for proBtype natriuretic peptide pro-BNP p0.001, neutrophil p0.001, hematocrit p0.001, and serum creatinine p0.001 in the ordinal logistic regression analysis, but not for MHR. MHR showed a negative correlation with left ventricular ejection fraction r: -0.151, p: 0.007, exhibited a positive association with pro-BNP r: 0.184, p0.001, and no correlation with New York Heart Association classes. There is a significant correlation between the MHR value and the factors associated with the severity of heart failure. The prognosis and management of this condition may be assessed by utilizing the MHR value in conjunction with existing biomarkers.

 The monocyteHDL-cholesterol ratio MHR was shown to be a marker of inflammation. This study investigated the utilization of this ratio as a measure of severity for heart failure which is a condition associated with inflammation. The MHR was calculated for 323 ambulatory patients with chronic heart failure and compared to other variables associated with the severity of the condition. Additionally, the impact of MHR on the Seattle Heart Failure Model SHFM score was investigated. MHR correlated positively with C-reactive protein r: 0.312, p0.001 and neutrophil-to-lymphocyte ratio r: 0.242, p0.001, but not with platelet-to-lymphocyte ratio. In addition, a correlation was found between the SHFM score and MHR r:-0.267, p0.001. The SHFM score exhibited a significant result for proBtype natriuretic peptide pro-BNP p0.001, neutrophil p0.001, hematocrit p0.001, and serum creatinine p0.001 in the ordinal logistic regression analysis, but not for MHR. MHR showed a negative correlation with left ventricular ejection fraction r: -0.151, p: 0.007, exhibited a positive association with pro-BNP r: 0.184, p0.001, and no correlation with New York Heart Association classes. There is a significant correlation between the MHR value and the factors associated with the severity of heart failure. The prognosis and management of this condition may be assessed by utilizing the MHR value in conjunction with existing biomarkers.

 The monocyteHDL-cholesterol ratio MHR was shown to be a marker of inflammation. This study investigated the utilization of this ratio as a measure of severity for heart failure which is a condition associated with inflammation. The MHR was calculated for 323 ambulatory patients with chronic heart failure and compared to other variables associated with the severity of the condition. Additionally, the impact of MHR on the Seattle Heart Failure Model SHFM score was investigated. MHR correlated positively with C-reactive protein r: 0.312, p0.001 and neutrophil-to-lymphocyte ratio r: 0.242, p0.001, but not with platelet-to-lymphocyte ratio. In addition, a correlation was found between the SHFM score and MHR r:-0.267, p0.001. The SHFM score exhibited a significant result for proBtype natriuretic peptide pro-BNP p0.001, neutrophil p0.001, hematocrit p0.001, and serum creatinine p0.001 in the ordinal logistic regression analysis, but not for MHR. MHR showed a negative correlation with left ventricular ejection fraction r: -0.151, p: 0.007, exhibited a positive association with pro-BNP r: 0.184, p0.001, and no correlation with New York Heart Association classes. There is a significant correlation between the MHR value and the factors associated with the severity of heart failure. The prognosis and management of this condition may be assessed by utilizing the MHR value in conjunction with existing biomarkers.

 The monocyteHDL-cholesterol ratio MHR was shown to be a marker of inflammation. This study investigated the utilization of this ratio as a measure of severity for heart failure which is a condition associated with inflammation. The MHR was calculated for 323 ambulatory patients with chronic heart failure and compared to other variables associated with the severity of the condition. Additionally, the impact of MHR on the Seattle Heart Failure Model SHFM score was investigated. MHR correlated positively with C-reactive protein r: 0.312, p0.001 and neutrophil-to-lymphocyte ratio r: 0.242, p0.001, but not with platelet-to-lymphocyte ratio. In addition, a correlation was found between the SHFM score and MHR r:-0.267, p0.001. The SHFM score exhibited a significant result for proBtype natriuretic peptide pro-BNP p0.001, neutrophil p0.001, hematocrit p0.001, and serum creatinine p0.001 in the ordinal logistic regression analysis, but not for MHR. MHR showed a negative correlation with left ventricular ejection fraction r: -0.151, p: 0.007, exhibited a positive association with pro-BNP r: 0.184, p0.001, and no correlation with New York Heart Association classes. There is a significant correlation between the MHR value and the factors associated with the severity of heart failure. The prognosis and management of this condition may be assessed by utilizing the MHR value in conjunction with existing biomarkers.

Makale detayları

The association between monocyte/HDL-C ratio and heart failure

Yazarlar:

Busra Nur Cattik | Nilay Aksoy | Barkın Berk | Barış Güngör

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 3, pp.1089-1097

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344612

pISSN:

2630-6344

HDL-cholesterol

heart failure

ınflammation

MHR

monocyte

Sayı

Makale detayları

The association between monocyte/HDL-C ratio and heart failure

Yazarlar: Busra Nur Cattik | Nilay Aksoy | Barkın Berk | Barış Güngör

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.29 Issue 3, pp.1089-1097

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001344612

pISSN: 2630-6344

HDL-cholesterol

heart failure

ınflammation

MHR

monocyte

Sayı

Yazarlar:

Busra Nur Cattik | Nilay Aksoy | Barkın Berk | Barış Güngör

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 3, pp.1089-1097

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344612

pISSN:

2630-6344