Phytochemical analysis, antioxidant and anticancer activities of durian (Durio zibethinus Murr.) fruit extract

N.A.

Makale detayları

Phytochemical analysis, antioxidant and anticancer activities of durian (Durio zibethinus Murr.) fruit extract

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Botany

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 6, pp.882-892

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348012

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Durian Durio zibethinus Murr. is a seasonal tropical fruit of Southeast Asia. It is a good source of carbohydrates, proteins, fibres, vitamins B and C. The fruit extract was prepared using the mixture of Ethanol and 0.2 M HCl 1:1, vv. Phytochemical, antioxidant and anticancer properties of durian were investigated in this study. Phytochemical analysis exhibited the highest total phenolics value of 116.551.51 mg GAEg extract and the highest total flavonoid value of 92.379.27 mg REg extract. In antioxidant studies, ABTS and NO assays of durian fruit extracts showed a greater value in antioxidant activity against control. Whereas, the results derived from DPPH, FRAP and other assays showed lower antioxidant potential compared to the standard. Since durian fruit possess rich phenolic content, which is the principal factor of the antioxidant activity, it shows excellent antioxidant potentials against various assay methods. MTT assay was used for the cytotoxicity of durian extract against Chang Liver cell lines. The percentage of cytotoxicity increases with the higher concentrations of durian extract. The maximum cytotoxicity 74 of fruit extract was recorded at 100 µgml of the fruit extract. It shows durian fruit extract to have an excellent anti-proliferative and anticancer activities against Chang liver cell lines. Hence durian fruit can be utilized as a potential source for rich bioactive compounds with nutraceutical and pharmaceutical applications.

 Durian Durio zibethinus Murr. is a seasonal tropical fruit of Southeast Asia. It is a good source of carbohydrates, proteins, fibres, vitamins B and C. The fruit extract was prepared using the mixture of Ethanol and 0.2 M HCl 1:1, vv. Phytochemical, antioxidant and anticancer properties of durian were investigated in this study. Phytochemical analysis exhibited the highest total phenolics value of 116.551.51 mg GAEg extract and the highest total flavonoid value of 92.379.27 mg REg extract. In antioxidant studies, ABTS and NO assays of durian fruit extracts showed a greater value in antioxidant activity against control. Whereas, the results derived from DPPH, FRAP and other assays showed lower antioxidant potential compared to the standard. Since durian fruit possess rich phenolic content, which is the principal factor of the antioxidant activity, it shows excellent antioxidant potentials against various assay methods. MTT assay was used for the cytotoxicity of durian extract against Chang Liver cell lines. The percentage of cytotoxicity increases with the higher concentrations of durian extract. The maximum cytotoxicity 74 of fruit extract was recorded at 100 µgml of the fruit extract. It shows durian fruit extract to have an excellent anti-proliferative and anticancer activities against Chang liver cell lines. Hence durian fruit can be utilized as a potential source for rich bioactive compounds with nutraceutical and pharmaceutical applications.

 Durian Durio zibethinus Murr. is a seasonal tropical fruit of Southeast Asia. It is a good source of carbohydrates, proteins, fibres, vitamins B and C. The fruit extract was prepared using the mixture of Ethanol and 0.2 M HCl 1:1, vv. Phytochemical, antioxidant and anticancer properties of durian were investigated in this study. Phytochemical analysis exhibited the highest total phenolics value of 116.551.51 mg GAEg extract and the highest total flavonoid value of 92.379.27 mg REg extract. In antioxidant studies, ABTS and NO assays of durian fruit extracts showed a greater value in antioxidant activity against control. Whereas, the results derived from DPPH, FRAP and other assays showed lower antioxidant potential compared to the standard. Since durian fruit possess rich phenolic content, which is the principal factor of the antioxidant activity, it shows excellent antioxidant potentials against various assay methods. MTT assay was used for the cytotoxicity of durian extract against Chang Liver cell lines. The percentage of cytotoxicity increases with the higher concentrations of durian extract. The maximum cytotoxicity 74 of fruit extract was recorded at 100 µgml of the fruit extract. It shows durian fruit extract to have an excellent anti-proliferative and anticancer activities against Chang liver cell lines. Hence durian fruit can be utilized as a potential source for rich bioactive compounds with nutraceutical and pharmaceutical applications.

 Durian Durio zibethinus Murr. is a seasonal tropical fruit of Southeast Asia. It is a good source of carbohydrates, proteins, fibres, vitamins B and C. The fruit extract was prepared using the mixture of Ethanol and 0.2 M HCl 1:1, vv. Phytochemical, antioxidant and anticancer properties of durian were investigated in this study. Phytochemical analysis exhibited the highest total phenolics value of 116.551.51 mg GAEg extract and the highest total flavonoid value of 92.379.27 mg REg extract. In antioxidant studies, ABTS and NO assays of durian fruit extracts showed a greater value in antioxidant activity against control. Whereas, the results derived from DPPH, FRAP and other assays showed lower antioxidant potential compared to the standard. Since durian fruit possess rich phenolic content, which is the principal factor of the antioxidant activity, it shows excellent antioxidant potentials against various assay methods. MTT assay was used for the cytotoxicity of durian extract against Chang Liver cell lines. The percentage of cytotoxicity increases with the higher concentrations of durian extract. The maximum cytotoxicity 74 of fruit extract was recorded at 100 µgml of the fruit extract. It shows durian fruit extract to have an excellent anti-proliferative and anticancer activities against Chang liver cell lines. Hence durian fruit can be utilized as a potential source for rich bioactive compounds with nutraceutical and pharmaceutical applications.

Makale detayları

Phytochemical analysis, antioxidant and anticancer activities of durian (Durio zibethinus Murr.) fruit extract

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Botany

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 6, pp.882-892

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348012

pISSN:

2630-6344

Durian

Durio zibethinus

antioxidants

anticancer

phytochemical

Sayı

Makale detayları

Phytochemical analysis, antioxidant and anticancer activities of durian (Durio zibethinus Murr.) fruit extract

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Botany

Dergi: Journal of Research in Pharmacy Vol.24 Issue 6, pp.882-892

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001348012

pISSN: 2630-6344

Durian

Durio zibethinus

antioxidants

anticancer

phytochemical

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Botany

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 6, pp.882-892

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348012

pISSN:

2630-6344