Determination of Median Values of Triple Test Screening Parameters in Kırşehir Province

Köksal Şerefli; Aynur Kırbaş; Ülken Tunga Babaoğlu

Makale detayları

Determination of Median Values of Triple Test Screening Parameters in Kırşehir Province

Yazarlar:

Köksal Şerefli | Aynur Kırbaş | Ülken Tunga Babaoğlu

Yayıncı:

Kirsehir Ahi Evran University

Ana Başlıklar:

Klinik Kimya

Dergi:

Ahi Evran Tıp Dergisi Vol.9 Issue 2, pp.180-185

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001345467

pISSN:

2619-9203

Anahtar kelimeler:

Özet:

 Purpose: It was aimed to recalculate the median values of the triple screening test parameters of Kırşehir province and compare them with the median values of the currently used SsdwLab 5 software program. Materials and Methods: Alpha-fetoprotein AFP, beta-human chorionic gonadotropin β-hCG and unconjugated estriol uE3 levels of 781 pregnant women admitted to Kırşehir Training and Research Hospital between 01.12.2022 - 01.12.2023 were retrospectively analyzed from the system. The difference between the median values obtained from the parameters and the median values recorded in the SsdwLab 5 program was statistically evaluated. Results: The 16th week β-hCG median value obtained from the data of pregnant individuals was found to be significantly higher than the median value in the program p0.001. The comparison of β-hCG median values at 15, 17 and 18 weeks showed no significant difference. The AFP median value obtained in all weeks studied 15-18 was significantly higher than the median value in the program and the uE3 median value was significantly lower than the median value in the program p0.001. Conclusion: The new median values we calculated were found to be statistically significantly different from the median values in the Ssdwlab 5 program. We think that recalculation and use of median values by laboratories will increase the effectiveness of screening tests, calculate prenatal risks more accurately and reduce interventional procedures.

 Purpose: It was aimed to recalculate the median values of the triple screening test parameters of Kırşehir province and compare them with the median values of the currently used SsdwLab 5 software program. Materials and Methods: Alpha-fetoprotein AFP, beta-human chorionic gonadotropin β-hCG and unconjugated estriol uE3 levels of 781 pregnant women admitted to Kırşehir Training and Research Hospital between 01.12.2022 - 01.12.2023 were retrospectively analyzed from the system. The difference between the median values obtained from the parameters and the median values recorded in the SsdwLab 5 program was statistically evaluated. Results: The 16th week β-hCG median value obtained from the data of pregnant individuals was found to be significantly higher than the median value in the program p0.001. The comparison of β-hCG median values at 15, 17 and 18 weeks showed no significant difference. The AFP median value obtained in all weeks studied 15-18 was significantly higher than the median value in the program and the uE3 median value was significantly lower than the median value in the program p0.001. Conclusion: The new median values we calculated were found to be statistically significantly different from the median values in the Ssdwlab 5 program. We think that recalculation and use of median values by laboratories will increase the effectiveness of screening tests, calculate prenatal risks more accurately and reduce interventional procedures.

 Purpose: It was aimed to recalculate the median values of the triple screening test parameters of Kırşehir province and compare them with the median values of the currently used SsdwLab 5 software program. Materials and Methods: Alpha-fetoprotein AFP, beta-human chorionic gonadotropin β-hCG and unconjugated estriol uE3 levels of 781 pregnant women admitted to Kırşehir Training and Research Hospital between 01.12.2022 - 01.12.2023 were retrospectively analyzed from the system. The difference between the median values obtained from the parameters and the median values recorded in the SsdwLab 5 program was statistically evaluated. Results: The 16th week β-hCG median value obtained from the data of pregnant individuals was found to be significantly higher than the median value in the program p0.001. The comparison of β-hCG median values at 15, 17 and 18 weeks showed no significant difference. The AFP median value obtained in all weeks studied 15-18 was significantly higher than the median value in the program and the uE3 median value was significantly lower than the median value in the program p0.001. Conclusion: The new median values we calculated were found to be statistically significantly different from the median values in the Ssdwlab 5 program. We think that recalculation and use of median values by laboratories will increase the effectiveness of screening tests, calculate prenatal risks more accurately and reduce interventional procedures.

 Amaç: Kırşehir iline ait üçlü tarama testi parametrelerinin medyan değerlerinin yeniden hesaplanması ve mevcut olarak kullanılan SsdwLab 5 yazılım programının medyan değerleriyle karşılaştırılması amaçlanmıştır. Araçlar ve Yöntem: Kırşehir Eğitim Araştırma Hastanesine 01.12.2022-01.12.2023 tarihleri arasında başvuran 781 gebenin alpha-fetoprotein AFP, beta-human chorionic gonadotropin β-hCG ve unconjugated estriol uE3 düzeyleri sistemden retrospektif olarak incelendi. Parametrelerden elde edilen medyan değerler ile SsdwLab 5 programında kayıtlı medyan değerlerin arasındaki fark istatistiksel olarak değerlendirilmiştir. Bulgular: Gebe bireylerin verilerinden elde edilen 16. hafta β-hCG medyan değerinin programdaki medyan değerinden anlamlı olarak daha yüksek olduğu bulunmuştur p0.001. 15. 17. ve 18. haftalardaki β-hCG medyan değeri karşılaştırmasında ise anlamlı bir fark olmadığı belirlenmiştir. Çalışılan tüm haftalarda 15-18 elde edilen AFP medyan değeri programdaki medyan değerinden anlamlı olarak daha yüksek, uE3 medyan değeri programdaki medyan değerinden anlamlı olarak daha düşük bulunmuştur p0.001. Sonuç: Hesapladığımız yeni medyan değerlerinin Ssdwlab 5 programında yer alan medyan değerlerinden istatistiksel olarak anlamlı farklılıkta olduğu bulunmuştur. Laboratuvarların medyan değerlerini yeniden hesaplayarak kullanmasının tarama testlerinin etkinliğini artıracağını, prenatal risklerin daha doğru hesaplanabileceğini ve girişimsel işlemleri azaltabileceğini düşünmekteyiz.

Makale detayları

Determination of Median Values of Triple Test Screening Parameters in Kırşehir Province

Yazarlar:

Köksal Şerefli | Aynur Kırbaş | Ülken Tunga Babaoğlu

Yayıncı:

Kirsehir Ahi Evran University

Ana Başlıklar:

Klinik Kimya

Dergi:

Ahi Evran Tıp Dergisi Vol.9 Issue 2, pp.180-185

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001345467

pISSN:

2619-9203

prenatal diagnosis

regional median

triple screening testbölgesel medyan

prenatal tanı

üçlü tarama testi

Sayı

Makale detayları

Determination of Median Values of Triple Test Screening Parameters in Kırşehir Province

Yazarlar: Köksal Şerefli | Aynur Kırbaş | Ülken Tunga Babaoğlu

Yayıncı: Kirsehir Ahi Evran University

Ana Başlıklar: Klinik Kimya

Dergi: Ahi Evran Tıp Dergisi Vol.9 Issue 2, pp.180-185

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: Türkçe

Document ID (Org No.): 2001345467

pISSN: 2619-9203

prenatal diagnosis

regional median

triple screening testbölgesel medyan

prenatal tanı

üçlü tarama testi

Sayı

Yazarlar:

Köksal Şerefli | Aynur Kırbaş | Ülken Tunga Babaoğlu

Yayıncı:

Kirsehir Ahi Evran University

Ana Başlıklar:

Klinik Kimya

Dergi:

Ahi Evran Tıp Dergisi Vol.9 Issue 2, pp.180-185

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001345467

pISSN:

2619-9203