Practical method in the diagnosis of diabetic ketoacidosis: end-tidal carbon dioxide

Ahmet Kayalı; Ejder Saylav Bora

Makale detayları

Practical method in the diagnosis of diabetic ketoacidosis: end-tidal carbon dioxide

Yazarlar:

Ahmet Kayalı | Ejder Saylav Bora

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Emergency Medicine

Dergi:

The European Research Journal Vol.10 Issue 3, pp.303-310

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001315676

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: Diabetic ketoacidosis DKA poses a life-threatening risk in uncontrolled diabetes. Current diagnostic criteria rely on invasive measures, leading to potential delays in treatment initiation. This study aimed to assess the diagnostic utility of noninvasive end-tidal carbon dioxide EtCO2 measurements in DKA patients. Methods: A prospective, cross-sectional study was conducted in a tertiary-level Emergency Medicine Clinic from January 2021 to January 2023. Participants included adults with DKA symptoms and those with stable vital signs as controls. EtCO2 levels were measured using a capnograph device. Diagnostic criteria for DKA were blood glucose 250 mgdL, ketonuria, ketonemia, and metabolic acidosis pH7.3 or bicarbonate 15 mEqdL. Statistical analysis was performed using SPSS Statistics. Results: Of 730 participants, 120 had DKA, 410 did not, and 200 served as controls. EtCO2 levels significantly differed between DKA, non-DKA, and control groups P0.05. EtCO2 correlated with pH, lactate, base deficit, and bicarbonate P0.05. ROC analysis showed an AUC of 0.86 for EtCO2 in diagnosing DKA P0.01, with 91.67 sensitivity and 74.39 specificity at a cut-off value 23.7. Conclusion: This study suggests that EtCO2 measurement is a valuable noninvasive tool for diagnosing and assessing the severity of DKA in the emergency department. An EtCO2 threshold of 23.7 could prompt consideration of DKA in patients with elevated blood glucose levels. More extensive multicenter studies are warranted to validate these findings further. EtCO2 measurement could facilitate early DKA diagnosis and improve patient outcomes.

 Objectives: Diabetic ketoacidosis DKA poses a life-threatening risk in uncontrolled diabetes. Current diagnostic criteria rely on invasive measures, leading to potential delays in treatment initiation. This study aimed to assess the diagnostic utility of noninvasive end-tidal carbon dioxide EtCO2 measurements in DKA patients. Methods: A prospective, cross-sectional study was conducted in a tertiary-level Emergency Medicine Clinic from January 2021 to January 2023. Participants included adults with DKA symptoms and those with stable vital signs as controls. EtCO2 levels were measured using a capnograph device. Diagnostic criteria for DKA were blood glucose 250 mgdL, ketonuria, ketonemia, and metabolic acidosis pH7.3 or bicarbonate 15 mEqdL. Statistical analysis was performed using SPSS Statistics. Results: Of 730 participants, 120 had DKA, 410 did not, and 200 served as controls. EtCO2 levels significantly differed between DKA, non-DKA, and control groups P0.05. EtCO2 correlated with pH, lactate, base deficit, and bicarbonate P0.05. ROC analysis showed an AUC of 0.86 for EtCO2 in diagnosing DKA P0.01, with 91.67 sensitivity and 74.39 specificity at a cut-off value 23.7. Conclusion: This study suggests that EtCO2 measurement is a valuable noninvasive tool for diagnosing and assessing the severity of DKA in the emergency department. An EtCO2 threshold of 23.7 could prompt consideration of DKA in patients with elevated blood glucose levels. More extensive multicenter studies are warranted to validate these findings further. EtCO2 measurement could facilitate early DKA diagnosis and improve patient outcomes.

 Objectives: Diabetic ketoacidosis DKA poses a life-threatening risk in uncontrolled diabetes. Current diagnostic criteria rely on invasive measures, leading to potential delays in treatment initiation. This study aimed to assess the diagnostic utility of noninvasive end-tidal carbon dioxide EtCO2 measurements in DKA patients. Methods: A prospective, cross-sectional study was conducted in a tertiary-level Emergency Medicine Clinic from January 2021 to January 2023. Participants included adults with DKA symptoms and those with stable vital signs as controls. EtCO2 levels were measured using a capnograph device. Diagnostic criteria for DKA were blood glucose 250 mgdL, ketonuria, ketonemia, and metabolic acidosis pH7.3 or bicarbonate 15 mEqdL. Statistical analysis was performed using SPSS Statistics. Results: Of 730 participants, 120 had DKA, 410 did not, and 200 served as controls. EtCO2 levels significantly differed between DKA, non-DKA, and control groups P0.05. EtCO2 correlated with pH, lactate, base deficit, and bicarbonate P0.05. ROC analysis showed an AUC of 0.86 for EtCO2 in diagnosing DKA P0.01, with 91.67 sensitivity and 74.39 specificity at a cut-off value 23.7. Conclusion: This study suggests that EtCO2 measurement is a valuable noninvasive tool for diagnosing and assessing the severity of DKA in the emergency department. An EtCO2 threshold of 23.7 could prompt consideration of DKA in patients with elevated blood glucose levels. More extensive multicenter studies are warranted to validate these findings further. EtCO2 measurement could facilitate early DKA diagnosis and improve patient outcomes.

 Objectives: Diabetic ketoacidosis DKA poses a life-threatening risk in uncontrolled diabetes. Current diagnostic criteria rely on invasive measures, leading to potential delays in treatment initiation. This study aimed to assess the diagnostic utility of noninvasive end-tidal carbon dioxide EtCO2 measurements in DKA patients. Methods: A prospective, cross-sectional study was conducted in a tertiary-level Emergency Medicine Clinic from January 2021 to January 2023. Participants included adults with DKA symptoms and those with stable vital signs as controls. EtCO2 levels were measured using a capnograph device. Diagnostic criteria for DKA were blood glucose 250 mgdL, ketonuria, ketonemia, and metabolic acidosis pH7.3 or bicarbonate 15 mEqdL. Statistical analysis was performed using SPSS Statistics. Results: Of 730 participants, 120 had DKA, 410 did not, and 200 served as controls. EtCO2 levels significantly differed between DKA, non-DKA, and control groups P0.05. EtCO2 correlated with pH, lactate, base deficit, and bicarbonate P0.05. ROC analysis showed an AUC of 0.86 for EtCO2 in diagnosing DKA P0.01, with 91.67 sensitivity and 74.39 specificity at a cut-off value 23.7. Conclusion: This study suggests that EtCO2 measurement is a valuable noninvasive tool for diagnosing and assessing the severity of DKA in the emergency department. An EtCO2 threshold of 23.7 could prompt consideration of DKA in patients with elevated blood glucose levels. More extensive multicenter studies are warranted to validate these findings further. EtCO2 measurement could facilitate early DKA diagnosis and improve patient outcomes.

Makale detayları

Practical method in the diagnosis of diabetic ketoacidosis: end-tidal carbon dioxide

Yazarlar:

Ahmet Kayalı | Ejder Saylav Bora

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Emergency Medicine

Dergi:

The European Research Journal Vol.10 Issue 3, pp.303-310

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001315676

pISSN:

2149-3189

Diabetic ketoacidosis

end tidal CO2

fast diagnosis

emergency medicine

Sayı

Makale detayları

Practical method in the diagnosis of diabetic ketoacidosis: end-tidal carbon dioxide

Yazarlar: Ahmet Kayalı | Ejder Saylav Bora

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Emergency Medicine

Dergi: The European Research Journal Vol.10 Issue 3, pp.303-310

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001315676

pISSN: 2149-3189

Diabetic ketoacidosis

end tidal CO2

fast diagnosis

emergency medicine

Sayı

Yazarlar:

Ahmet Kayalı | Ejder Saylav Bora

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Emergency Medicine

Dergi:

The European Research Journal Vol.10 Issue 3, pp.303-310

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001315676

pISSN:

2149-3189