The Effect of Sex on Ischemia - Reperfusion Induced Arrhythmias and the Role of Atp - Dependent Potassium Channel Blockage

Ersöz GONCA; Eylem Suveren TİRYAKİ; Ömer BOZDOĞAN

Makale detayları

The Effect of Sex on Ischemia - Reperfusion Induced Arrhythmias and the Role of Atp - Dependent Potassium Channel Blockage

Yazarlar:

Ersöz GONCA | Eylem Suveren TİRYAKİ | Ömer BOZDOĞAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2004 Vol.28 Issue 1, pp.39-46

Belge Tipi:

Makale

Yayın Tarihi:

12/2003

Belge Dili:

Türkçe

Document ID (Org No.):

2000813567

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Anahtar kelimeler:

Özet:

 

The presence of more  ATP-dependent potassium channels in females has been thought to play an important role in protection  against myocardial ischemia. In this study, we investigated whether there is a difference in the severity of ischemia and reperfusion  induced arrhythmias due to  sex  and, if there is, what the role of ATP-dependent  potassium channel in this difference is. The  left anterior descending  coronary artery in rats was ligated and arrhythmias were recorded in ECG during  6 min. of ischemia and reperfusion. The duration of arrhythmias was shorter in females than in corresponding males. Glibenclamide was effective in decreasing the duration of arrhythmias in males but not in females. This may be due to the presence of more ATP-dependent potassium channels in females.

 

The presence of more  ATP-dependent potassium channels in females has been thought to play an important role in protection  against myocardial ischemia. In this study, we investigated whether there is a difference in the severity of ischemia and reperfusion  induced arrhythmias due to  sex  and, if there is, what the role of ATP-dependent  potassium channel in this difference is. The  left anterior descending  coronary artery in rats was ligated and arrhythmias were recorded in ECG during  6 min. of ischemia and reperfusion. The duration of arrhythmias was shorter in females than in corresponding males. Glibenclamide was effective in decreasing the duration of arrhythmias in males but not in females. This may be due to the presence of more ATP-dependent potassium channels in females.

Makale detayları

The Effect of Sex on Ischemia - Reperfusion Induced Arrhythmias and the Role of Atp - Dependent Potassium Channel Blockage

Yazarlar:

Ersöz GONCA | Eylem Suveren TİRYAKİ | Ömer BOZDOĞAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2004 Vol.28 Issue 1, pp.39-46

Belge Tipi:

Makale

Yayın Tarihi:

12/2003

Belge Dili:

Türkçe

Document ID (Org No.):

2000813567

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Coronary Ligation

Ischemia-Reperfusion

Arrhythmias

Sex

Glibenclamide

Sayı

Makale detayları

The Effect of Sex on Ischemia - Reperfusion Induced Arrhythmias and the Role of Atp - Dependent Potassium Channel Blockage

Yazarlar: Ersöz GONCA | Eylem Suveren TİRYAKİ | Ömer BOZDOĞAN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Biology 2004 Vol.28 Issue 1, pp.39-46

Belge Tipi: Makale

Yayın Tarihi: 12/2003

Belge Dili: Türkçe

Document ID (Org No.): 2000813567

Sıklık: İki Aylık

eISSN: 1303-6092

pISSN: 1300-0152

Coronary Ligation

Ischemia-Reperfusion

Arrhythmias

Sex

Glibenclamide

Sayı

Yazarlar:

Ersöz GONCA | Eylem Suveren TİRYAKİ | Ömer BOZDOĞAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2004 Vol.28 Issue 1, pp.39-46

Belge Tipi:

Makale

Yayın Tarihi:

12/2003

Belge Dili:

Türkçe

Document ID (Org No.):

2000813567

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152