Il-6 Levels in Induced Sputum and Serum in Acute Attack and Stable Period of Chronic Obstructive Pulmonary Disease

Makbule Özlem AKBAY; Feza UGURMAN

Makale detayları

Il-6 Levels in Induced Sputum and Serum in Acute Attack and Stable Period of Chronic Obstructive Pulmonary Disease

Yazarlar:

Makbule Özlem AKBAY | Feza UGURMAN

Yayıncı:

Fazile Nur EKİNCİ AKDEMİR

Ana Başlıklar:

Hastalıklar

Dergi:

New Trends in Medicine Sciences 2021 Vol.2 Issue 2, pp.150-156

Belge Tipi:

Makale

Yayın Tarihi:

9/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000617565

Sıklık:

İki Yıllık

eISSN:

2717-8161

pISSN:

2717-8161

Özet:

 

Introduction: COPD is a disease characterized by chronic inflammation in the airways and increased systemic inflammation. Interleukin-6 is a major immune and inflammatory mediator.
Objective: To examine the level of IL-6, an inflammatory mediator, in induced sputum and serum of patients with COPD in the acute attack and stable period.
Materials and Methods: Thirty consecutive patients diagnosed with COPD were included in the study. In the attack and stable period, IL-6 levels were studied in the induced sputum and blood taken simultaneously. Twenty-one patients who did not have any pathological findings in terms of chest diseases were selected as the control group. ELISA kit (Bender MedSystems, Vienna, Austria) was used for IL-6 measurements and values were measured as pg/ml. Mann-Whitney U test was used for intergroup comparisons and Wilcoxon Signed Ranks test was used for intragroup comparisons.
Results: The serum IL-6 level in the patient group was 6.66±7.49 pg/ml in the acute attack, while it was 3.08±4.07 pg/ml in the stable period. This decrease was found to be statistically significant (p<0.005). Sputum IL-6 level did not show a statistically significant change in acute attack (3.54±2.75 pg/ml) and stable period (3.44±6.03 pg/ml). In our study, there was a negative correlation between sputum IL-6 level in acute attack and COPD year (p: 0.02, r: -0.42). A positive correlation was found between acute attack serum IL-6 level ( p:0.007,r:0.479) and stable period sputum IL-6 levels (p:0.017, r:0.429) and the number of acute attacks.
Conclusion: The high serum IL-6 level in COPD attack shows that the immune response is not only in the respiratory system, but also systemically, and supports that COPD is a systemic inflammatory disease. In our study, we could not detect any contribution of IL-6 level in induced sputum. Studies involving larger numbers of cases and evaluating multiple markers are needed.

Makale detayları

Il-6 Levels in Induced Sputum and Serum in Acute Attack and Stable Period of Chronic Obstructive Pulmonary Disease

Yazarlar: Makbule Özlem AKBAY | Feza UGURMAN

Yayıncı: Fazile Nur EKİNCİ AKDEMİR

Ana Başlıklar: Hastalıklar

Dergi: New Trends in Medicine Sciences 2021 Vol.2 Issue 2, pp.150-156

Belge Tipi: Makale

Yayın Tarihi: 9/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000617565

Sıklık: İki Yıllık

eISSN: 2717-8161

pISSN: 2717-8161

Sayı

Yazarlar:

Makbule Özlem AKBAY | Feza UGURMAN

Yayıncı:

Fazile Nur EKİNCİ AKDEMİR

Ana Başlıklar:

Hastalıklar

Dergi:

New Trends in Medicine Sciences 2021 Vol.2 Issue 2, pp.150-156

Belge Tipi:

Makale

Yayın Tarihi:

9/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000617565

Sıklık:

İki Yıllık

eISSN:

2717-8161

pISSN:

2717-8161