DETAILED ELECTROCHEMICAL BEHAVIOR INVESTIGATION AND DETERMINATION OF ANTIPSYCHOTIC DRUG PALIPERIDONE ON A GLASSY CARBON ELECTRODE

Sariye İrem Kaya; Ece Ozkan; Nurgul Karadas Bakirhan; Sibel A. Özkan

Makale detayları

DETAILED ELECTROCHEMICAL BEHAVIOR INVESTIGATION AND DETERMINATION OF ANTIPSYCHOTIC DRUG PALIPERIDONE ON A GLASSY CARBON ELECTRODE

Yazarlar:

Sariye İrem Kaya | Ece Ozkan | Nurgul Karadas Bakirhan | Sibel A. Özkan

Yayıncı:

Ankara University

Ana Başlıklar:

Eczacılıkta Analitik Kimya

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 1, pp.1-11

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001333043

pISSN:

1015-3918

Anahtar kelimeler:

Özet:

 Objective: A sensitive and cost-effective electrochemical method was developed on a bare glassy carbon electrode GCE for the determination of paliperidone PAL, an antipsychotic drug used in the primary schizophrenia treatment affecting the whole world. Material and Method: The oxidation studies carried out in pH 8 phosphate buffer solution PBS by cyclic voltammetry CV showed that the oxidation reaction of PAL is a process including the same number of electrons and protons. The electrochemical detection of PAL was carried out by differential pulse voltammetry DPV. Result and Discussion: The linearity range was between 1 µM and 100 µM. The limit of detection LOD and quantification LOQ values were calculated as 2.41x10-7 M and 8.033x10-7 M, respectively. The applicability of the developed method was confirmed by using it on synthetic human serum. The relative standard deviation RSD values were less than 2. The selectivity of the analysis was demonstrated over against interfering substances such as ascorbic acid, KNO3, MgCl2, paracetamol, dopamine, Na2SO4, and uric acid with recovery and RSD values in the range 98.32-101.56 and 0.15-1.99, respectively. The proposed method provided high sensitivity for PAL and is the first reported method for the electroanalysis of PAL.

 Objective: A sensitive and cost-effective electrochemical method was developed on a bare glassy carbon electrode GCE for the determination of paliperidone PAL, an antipsychotic drug used in the primary schizophrenia treatment affecting the whole world. Material and Method: The oxidation studies carried out in pH 8 phosphate buffer solution PBS by cyclic voltammetry CV showed that the oxidation reaction of PAL is a process including the same number of electrons and protons. The electrochemical detection of PAL was carried out by differential pulse voltammetry DPV. Result and Discussion: The linearity range was between 1 µM and 100 µM. The limit of detection LOD and quantification LOQ values were calculated as 2.41x10-7 M and 8.033x10-7 M, respectively. The applicability of the developed method was confirmed by using it on synthetic human serum. The relative standard deviation RSD values were less than 2. The selectivity of the analysis was demonstrated over against interfering substances such as ascorbic acid, KNO3, MgCl2, paracetamol, dopamine, Na2SO4, and uric acid with recovery and RSD values in the range 98.32-101.56 and 0.15-1.99, respectively. The proposed method provided high sensitivity for PAL and is the first reported method for the electroanalysis of PAL.

 Objective: A sensitive and cost-effective electrochemical method was developed on a bare glassy carbon electrode GCE for the determination of paliperidone PAL, an antipsychotic drug used in the primary schizophrenia treatment affecting the whole world. Material and Method: The oxidation studies carried out in pH 8 phosphate buffer solution PBS by cyclic voltammetry CV showed that the oxidation reaction of PAL is a process including the same number of electrons and protons. The electrochemical detection of PAL was carried out by differential pulse voltammetry DPV. Result and Discussion: The linearity range was between 1 µM and 100 µM. The limit of detection LOD and quantification LOQ values were calculated as 2.41x10-7 M and 8.033x10-7 M, respectively. The applicability of the developed method was confirmed by using it on synthetic human serum. The relative standard deviation RSD values were less than 2. The selectivity of the analysis was demonstrated over against interfering substances such as ascorbic acid, KNO3, MgCl2, paracetamol, dopamine, Na2SO4, and uric acid with recovery and RSD values in the range 98.32-101.56 and 0.15-1.99, respectively. The proposed method provided high sensitivity for PAL and is the first reported method for the electroanalysis of PAL.

 Amaç: Tüm dünyayı etkileyen şizofreninin birincil tedavisinde kullanılan antipsikotik ilaç olan paliperidonun PAL tayini için yalın camsı karbon elektrot CKE kullanılarak hassas ve uygun maliyetli bir elektrokimyasal yöntem geliştirildi. Gereç ve Yöntem: pH 8 fosfat tampon çözeltisinde dönüşümlü voltametri DV ile gerçekleştirilen oksidasyon çalışmaları, PALın oksidasyon reaksiyonunun iki elektron ve iki protonlu bir süreç olduğunu gösterdi. PALın elektrokimyasal tespiti diferansiyel puls voltametrisi DPV ile gerçekleştirildi. Sonuç ve Tartışma: Doğrusal aralık 1x10-6 M ile 1x10-4 M arasında bulundu. Teşhis sınırı TS ve tayin alt sınırı TAS değerleri sırasıyla 2.41x10-7 M ve 8.033x10-7 M olarak hesaplandı. Geliştirilen yöntemin uygulanabilirliği sentetik insan serumu üzerinde kullanılarak doğrulandı. Bağıl standart sapma BSS değerleri 2den azdı. Yöntemin seçiciliği, askorbik asit, KNO3, MgCl2, parasetamol, dopamin, Na2SO4 ve ürik asit gibi girişim etkili ajanların varlığında sırasıyla 98.32-101.56 ve 0.15-1.99 aralığında geri kazanım ve BSS değerleri ile gösterilmiştir. Önerilen yöntem PAL için yüksek hassasiyet sağlamıştır ve PALin elektroanalizi için bildirilen ilk yöntemdir.

Makale detayları

DETAILED ELECTROCHEMICAL BEHAVIOR INVESTIGATION AND DETERMINATION OF ANTIPSYCHOTIC DRUG PALIPERIDONE ON A GLASSY CARBON ELECTRODE

Yazarlar:

Sariye İrem Kaya | Ece Ozkan | Nurgul Karadas Bakirhan | Sibel A. Özkan

Yayıncı:

Ankara University

Ana Başlıklar:

Eczacılıkta Analitik Kimya

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 1, pp.1-11

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001333043

pISSN:

1015-3918

Differential pulse voltammetry

electrochemistry

glassy carbon electrode

paliperidoneCamsı karbon elektrot

diferansiyel darbe voltametrisi

elektrokimya

paliperidon

Sayı

Makale detayları

Yazarlar: Sariye İrem Kaya | Ece Ozkan | Nurgul Karadas Bakirhan | Sibel A. Özkan

Yayıncı: Ankara University

Ana Başlıklar: Eczacılıkta Analitik Kimya

Dergi: Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 1, pp.1-11

Belge Tipi: Makale

Yayın Tarihi: 1/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001333043

pISSN: 1015-3918

Sayı

Yazarlar:

Sariye İrem Kaya | Ece Ozkan | Nurgul Karadas Bakirhan | Sibel A. Özkan

Yayıncı:

Ankara University

Ana Başlıklar:

Eczacılıkta Analitik Kimya

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 1, pp.1-11

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001333043

pISSN:

1015-3918