Evaluation of the anti-oxidant and anti-obesity effects of  ethanolic extract of Ficus auriculata Lour. fruit

Pattilthodika Suhail

Makale detayları

Evaluation of the anti-oxidant and anti-obesity effects of ethanolic extract of Ficus auriculata Lour. fruit

Yazarlar:

Pattilthodika Suhail

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 1, pp.287-294

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001339615

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Ficus auriculata F. auriculata, a deciduous tree in the Moraceae family, is a globally significant crop. Because of its abundance of phytochemicals and antioxidants, which are essential to human health, the fig tree is revered as a holy tree. The goal of this study was to determine if the ethanolic extract of F. auriculata fruit has any anti-oxidant or anti obesity effects, both in vitro and in vivo. The DPPH free radical technique for the quantitative determination of free radical scavenging activity and the inhibitory action against pancreatic lipase was measured using p-nitrophenyl butyrate p-NPB as a substrate. Blood serum was collected for serum lipid profile determination, histopathological analysis using hematoxylin and eosin stain, and results were viewed using a microscope at x400 magnification. From the results obtained, F. auriculata fruit had a large number of phenolic compounds and possible antioxidant components. The IC50 value of the sample was found to be 49.99 µgmL. The extract exhibited the highest lipase inhibitory action, with an IC50 value of 45.61 µgmL. At a dosage of 300 mgkg, the extract reduced serum lipid profile and body weight in a manner similar to that of the standard drug orlistat and exhibited a reduction in the crown-like structure CLSmm3 to 4 CLSmm3, while the control group had 34 CLSmm3. Thus, the anti-obesity properties of F. auriculata fruit were confirmed using an HCD-induced obesity rat model. It reduced sugar levels, improved lipid profiles, reduced hepatic steatosis, slowed weight gain, and altered the histological marker of local inflammation.

 Ficus auriculata F. auriculata, a deciduous tree in the Moraceae family, is a globally significant crop. Because of its abundance of phytochemicals and antioxidants, which are essential to human health, the fig tree is revered as a holy tree. The goal of this study was to determine if the ethanolic extract of F. auriculata fruit has any anti-oxidant or anti obesity effects, both in vitro and in vivo. The DPPH free radical technique for the quantitative determination of free radical scavenging activity and the inhibitory action against pancreatic lipase was measured using p-nitrophenyl butyrate p-NPB as a substrate. Blood serum was collected for serum lipid profile determination, histopathological analysis using hematoxylin and eosin stain, and results were viewed using a microscope at x400 magnification. From the results obtained, F. auriculata fruit had a large number of phenolic compounds and possible antioxidant components. The IC50 value of the sample was found to be 49.99 µgmL. The extract exhibited the highest lipase inhibitory action, with an IC50 value of 45.61 µgmL. At a dosage of 300 mgkg, the extract reduced serum lipid profile and body weight in a manner similar to that of the standard drug orlistat and exhibited a reduction in the crown-like structure CLSmm3 to 4 CLSmm3, while the control group had 34 CLSmm3. Thus, the anti-obesity properties of F. auriculata fruit were confirmed using an HCD-induced obesity rat model. It reduced sugar levels, improved lipid profiles, reduced hepatic steatosis, slowed weight gain, and altered the histological marker of local inflammation.

 Ficus auriculata F. auriculata, a deciduous tree in the Moraceae family, is a globally significant crop. Because of its abundance of phytochemicals and antioxidants, which are essential to human health, the fig tree is revered as a holy tree. The goal of this study was to determine if the ethanolic extract of F. auriculata fruit has any anti-oxidant or anti obesity effects, both in vitro and in vivo. The DPPH free radical technique for the quantitative determination of free radical scavenging activity and the inhibitory action against pancreatic lipase was measured using p-nitrophenyl butyrate p-NPB as a substrate. Blood serum was collected for serum lipid profile determination, histopathological analysis using hematoxylin and eosin stain, and results were viewed using a microscope at x400 magnification. From the results obtained, F. auriculata fruit had a large number of phenolic compounds and possible antioxidant components. The IC50 value of the sample was found to be 49.99 µgmL. The extract exhibited the highest lipase inhibitory action, with an IC50 value of 45.61 µgmL. At a dosage of 300 mgkg, the extract reduced serum lipid profile and body weight in a manner similar to that of the standard drug orlistat and exhibited a reduction in the crown-like structure CLSmm3 to 4 CLSmm3, while the control group had 34 CLSmm3. Thus, the anti-obesity properties of F. auriculata fruit were confirmed using an HCD-induced obesity rat model. It reduced sugar levels, improved lipid profiles, reduced hepatic steatosis, slowed weight gain, and altered the histological marker of local inflammation.

 Ficus auriculata F. auriculata, a deciduous tree in the Moraceae family, is a globally significant crop. Because of its abundance of phytochemicals and antioxidants, which are essential to human health, the fig tree is revered as a holy tree. The goal of this study was to determine if the ethanolic extract of F. auriculata fruit has any anti-oxidant or anti obesity effects, both in vitro and in vivo. The DPPH free radical technique for the quantitative determination of free radical scavenging activity and the inhibitory action against pancreatic lipase was measured using p-nitrophenyl butyrate p-NPB as a substrate. Blood serum was collected for serum lipid profile determination, histopathological analysis using hematoxylin and eosin stain, and results were viewed using a microscope at x400 magnification. From the results obtained, F. auriculata fruit had a large number of phenolic compounds and possible antioxidant components. The IC50 value of the sample was found to be 49.99 µgmL. The extract exhibited the highest lipase inhibitory action, with an IC50 value of 45.61 µgmL. At a dosage of 300 mgkg, the extract reduced serum lipid profile and body weight in a manner similar to that of the standard drug orlistat and exhibited a reduction in the crown-like structure CLSmm3 to 4 CLSmm3, while the control group had 34 CLSmm3. Thus, the anti-obesity properties of F. auriculata fruit were confirmed using an HCD-induced obesity rat model. It reduced sugar levels, improved lipid profiles, reduced hepatic steatosis, slowed weight gain, and altered the histological marker of local inflammation.

Makale detayları

Evaluation of the anti-oxidant and anti-obesity effects of ethanolic extract of Ficus auriculata Lour. fruit

Yazarlar:

Pattilthodika Suhail

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 1, pp.287-294

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001339615

pISSN:

2630-6344

Ficus auriculata

anti-oxidant activity

anti-obesity activity

pancreatic lipase inhibition

hepatic steatosis

Sayı

Makale detayları

Evaluation of the anti-oxidant and anti-obesity effects of ethanolic extract of Ficus auriculata Lour. fruit

Yazarlar: Pattilthodika Suhail

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.29 Issue 1, pp.287-294

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001339615

pISSN: 2630-6344

Ficus auriculata

anti-oxidant activity

anti-obesity activity

pancreatic lipase inhibition

hepatic steatosis

Sayı

Yazarlar:

Pattilthodika Suhail

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 1, pp.287-294

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001339615

pISSN:

2630-6344