Postoperative cognitive dysfunction and Alzheimer disease

BERRİN IŞIK

Makale detayları

Postoperative cognitive dysfunction and Alzheimer disease

Yazarlar:

BERRİN IŞIK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 5, pp.1015-1019

Belge Tipi:

Makale

Yayın Tarihi:

12/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752481

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Alzheimer disease (AD) is the most prevalent neurodegenerative disorder in elderly people. Patients with AD appear to be particularly at risk for cognitive deterioration following anesthesia. Some in vitro studies suggest that exposure to general anesthesia (GA) promotes the AD process. On the other hand, there are no clinical studies that clearly demonstrate that GA is a cause of cognitive dysfunction in patients with probable AD. The aim of this research was to discuss the relation between postoperative cognitive dysfunction (POCD) and AD according to the literature. In vivo studies examining AD biomarkers postoperatively and in vitro studies exploring amyloid-β (Aβ) converge to indicate that anesthetics could affect AD pathogenesis, either directly or indirectly. Careful evaluation of the mental state should be mandatory for all elderly patients undergoing GA. Long-term prospective, randomized clinical studies are required to examine the relationship between POCD and AD.

 

Alzheimer disease (AD) is the most prevalent neurodegenerative disorder in elderly people. Patients with AD appear to be particularly at risk for cognitive deterioration following anesthesia. Some in vitro studies suggest that exposure to general anesthesia (GA) promotes the AD process. On the other hand, there are no clinical studies that clearly demonstrate that GA is a cause of cognitive dysfunction in patients with probable AD. The aim of this research was to discuss the relation between postoperative cognitive dysfunction (POCD) and AD according to the literature. In vivo studies examining AD biomarkers postoperatively and in vitro studies exploring amyloid-β (Aβ) converge to indicate that anesthetics could affect AD pathogenesis, either directly or indirectly. Careful evaluation of the mental state should be mandatory for all elderly patients undergoing GA. Long-term prospective, randomized clinical studies are required to examine the relationship between POCD and AD.

Makale detayları

Postoperative cognitive dysfunction and Alzheimer disease

Yazarlar:

BERRİN IŞIK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 5, pp.1015-1019

Belge Tipi:

Makale

Yayın Tarihi:

12/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752481

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anesthesia

postoperative cognitive dysfunction

Alzheimer disease

Sayı

Makale detayları

Postoperative cognitive dysfunction and Alzheimer disease

Yazarlar: BERRİN IŞIK

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2015 Vol.45 Issue 5, pp.1015-1019

Belge Tipi: Makale

Yayın Tarihi: 12/2015

Belge Dili: Türkçe

Document ID (Org No.): 2000752481

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Anesthesia

postoperative cognitive dysfunction

Alzheimer disease

Sayı

Yazarlar:

BERRİN IŞIK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 5, pp.1015-1019

Belge Tipi:

Makale

Yayın Tarihi:

12/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752481

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144