Investigation of Biochemical and Hematological Parameters of Workers Exposed to Benzene

Oya Torun GÜNGÖR; Ceylan BAL; Müjgan ERCAN; Asım HOCAOĞLU; Meşide GÜNDÜZÖZ; Sedat ABUŞOĞLU; Lutfiye TUTKUN; Ömer Hınç YILMAZ

Makale detayları

Investigation of Biochemical and Hematological Parameters of Workers Exposed to Benzene

Yazarlar:

Oya Torun GÜNGÖR | Ceylan BAL | Müjgan ERCAN | Asım HOCAOĞLU | Meşide GÜNDÜZÖZ | Sedat ABUŞOĞLU | Lutfiye TUTKUN | Ömer Hınç YILMAZ

Yayıncı:

Engin TUTKUN

Dergi:

The Turkish Journal Of Occupational / Environmental Medicine and Safety 2015 Vol.1 Issue 1

Belge Tipi:

Makale

Yayın Tarihi:

5/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000835838

Sıklık:

Üç Aylık

eISSN:

2149-4711

pISSN:

2149-4711

Özet:

 

Benzene is the basic member of organic compounds classified as aromatic hydrocarbons. In many studies, it is determined that the risk of acute myeloid leukaemia (AML) or other leukaemias increase in conditions of recurrent exposure of benzene and products containing benzene. Benzene exposure can be determined by the analysis of phenol in urine. The aim of this study is to assess retrospectively the biochemical and hematological markers of workers who exposed to benzene.189 patients were included in this study who referred to Ankara Occupational Diseases Hospital for periodical examination that had exposed to benzene. 151 persons were included as control group. Phenol analysis was made by Agilent Gas Chromatography device, biochemical parameters by Konelab Prime 60i device, whole blood analysis by Beckman Coulter LH780 device and sedimentation measurement by Alifax device.While there were not a significant difference between benzene exposed workers and control group in aspartate aminotranspherase (AST), alanine aminotranspherase (ALT), creatinine, C-reactive protein, sedimentation and lymphocyte levels (p values; 0.935, 0.576, 0.673, 0.110, 0.171, 0.157 respectively), there were a significant difference in erithrocyte, leukocyte, hemoglobine, neutrophil and blood urea nitrogen levels (p values; 0.021, 0.045, 0.001, 0.018, 0.017 respectively). The mean erythrocyte and hemoglobine values were lower in benzene exposed workers according to control group, but the mean leukocyte, neutrophil and blood urea nitrogen values were higher in benzene exposed workers according to control group.As a result, although hematological effects of benzene and the relation between benzene and AML or other leukaemias were retained, we think that it should be investigated in more detail the effects on other systems in case of chronic exposure.

 

Benzene is the basic member of organic compounds classified as aromatic hydrocarbons. In many studies, it is determined that the risk of acute myeloid leukaemia (AML) or other leukaemias increase in conditions of recurrent exposure of benzene and products containing benzene. Benzene exposure can be determined by the analysis of phenol in urine. The aim of this study is to assess retrospectively the biochemical and hematological markers of workers who exposed to benzene.189 patients were included in this study who referred to Ankara Occupational Diseases Hospital for periodical examination that had exposed to benzene. 151 persons were included as control group. Phenol analysis was made by Agilent Gas Chromatography device, biochemical parameters by Konelab Prime 60i device, whole blood analysis by Beckman Coulter LH780 device and sedimentation measurement by Alifax device.While there were not a significant difference between benzene exposed workers and control group in aspartate aminotranspherase (AST), alanine aminotranspherase (ALT), creatinine, C-reactive protein, sedimentation and lymphocyte levels (p values; 0.935, 0.576, 0.673, 0.110, 0.171, 0.157 respectively), there were a significant difference in erithrocyte, leukocyte, hemoglobine, neutrophil and blood urea nitrogen levels (p values; 0.021, 0.045, 0.001, 0.018, 0.017 respectively). The mean erythrocyte and hemoglobine values were lower in benzene exposed workers according to control group, but the mean leukocyte, neutrophil and blood urea nitrogen values were higher in benzene exposed workers according to control group.As a result, although hematological effects of benzene and the relation between benzene and AML or other leukaemias were retained, we think that it should be investigated in more detail the effects on other systems in case of chronic exposure.

Makale detayları

Investigation of Biochemical and Hematological Parameters of Workers Exposed to Benzene

Yazarlar: Oya Torun GÜNGÖR | Ceylan BAL | Müjgan ERCAN | Asım HOCAOĞLU | Meşide GÜNDÜZÖZ | Sedat ABUŞOĞLU | Lutfiye TUTKUN | Ömer Hınç YILMAZ

Yayıncı: Engin TUTKUN

Dergi: The Turkish Journal Of Occupational / Environmental Medicine and Safety 2015 Vol.1 Issue 1

Belge Tipi: Makale

Yayın Tarihi: 5/2015

Belge Dili: Türkçe

Document ID (Org No.): 2000835838

Sıklık: Üç Aylık

eISSN: 2149-4711

pISSN: 2149-4711

Sayı

Yazarlar:

Oya Torun GÜNGÖR | Ceylan BAL | Müjgan ERCAN | Asım HOCAOĞLU | Meşide GÜNDÜZÖZ | Sedat ABUŞOĞLU | Lutfiye TUTKUN | Ömer Hınç YILMAZ

Yayıncı:

Engin TUTKUN

Dergi:

The Turkish Journal Of Occupational / Environmental Medicine and Safety 2015 Vol.1 Issue 1

Belge Tipi:

Makale

Yayın Tarihi:

5/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000835838

Sıklık:

Üç Aylık

eISSN:

2149-4711

pISSN:

2149-4711