HPLC Method for the Analysis of Paracetamol, Caffeine and Dipyrone

M. Levent ALTUN

Makale detayları

HPLC Method for the Analysis of Paracetamol, Caffeine and Dipyrone

Yazarlar:

M. Levent ALTUN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2002 Vol.26 Issue 4, pp.521-528

Belge Tipi:

Makale

Yayın Tarihi:

3/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000729828

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

An accurate, simple, reproducible and sensitive method for the   determination of paracetamol, caffeine and dipyrone was developed and   validated. Paracetamol, caffeine and dipyrone were separated using a    m -Bondapack C 8  column by isocratic elution with a flow   rate of 1.0 ml/min. The mobile phase composition was 0.01 M KH2PO4- -methanol-acetonitrile-isopropyl alcohol (420: 20: 30: 30)   (v/v/v/v) and spectrophotometric detection was carried out at 215 nm.   The linear range of determination for paracetamol, caffeine and   dipyrone were 0.409-400 m g/ml, 0.151-200  m g/ml and   0.233-600 m g/ml, respectively. The method was shown  to be   linear, reproducible, specific, sensitive and rugged.

 

An accurate, simple, reproducible and sensitive method for the   determination of paracetamol, caffeine and dipyrone was developed and   validated. Paracetamol, caffeine and dipyrone were separated using a    m -Bondapack C 8  column by isocratic elution with a flow   rate of 1.0 ml/min. The mobile phase composition was 0.01 M KH2PO4- -methanol-acetonitrile-isopropyl alcohol (420: 20: 30: 30)   (v/v/v/v) and spectrophotometric detection was carried out at 215 nm.   The linear range of determination for paracetamol, caffeine and   dipyrone were 0.409-400 m g/ml, 0.151-200  m g/ml and   0.233-600 m g/ml, respectively. The method was shown  to be   linear, reproducible, specific, sensitive and rugged.

Makale detayları

HPLC Method for the Analysis of Paracetamol, Caffeine and Dipyrone

Yazarlar: M. Levent ALTUN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2002 Vol.26 Issue 4, pp.521-528

Belge Tipi: Makale

Yayın Tarihi: 3/2002

Belge Dili: Türkçe

Document ID (Org No.): 2000729828

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

M. Levent ALTUN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2002 Vol.26 Issue 4, pp.521-528

Belge Tipi:

Makale

Yayın Tarihi:

3/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000729828

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527