Paricalcitol inhibits the Wnt/beta-catenin signaling pathway and ameliorates  experimentally induced arthritis

Servet YOLBAŞ; Ahmet YILDIRIM; Ahmet TEKTEMUR; Zulfinaz Betül ÇELİK; Ebru ÖNALAN ETEM; İbrahim Hanifi ÖZERCAN; Mehmet Mustafa AKIN; Süleyman Serdar KOCA

Makale detayları

Paricalcitol inhibits the Wnt/beta-catenin signaling pathway and ameliorates experimentally induced arthritis

Yazarlar:

Servet YOLBAŞ | Ahmet YILDIRIM | Ahmet TEKTEMUR | Zulfinaz Betül ÇELİK | Ebru ÖNALAN ETEM | İbrahim Hanifi ÖZERCAN | Mehmet Mustafa AKIN | Süleyman Serdar KOCA

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 5, pp.1080-1086

Belge Tipi:

Makale

Yayın Tarihi:

10/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000750600

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 


 
                         Background/aim: The Wnt/ß-catenin pathway has important biological activities, including the differentiation of cells and joint
formations. The aim of our study was to determine the effect of paricalcitol on experimentally induced arthritis.
Materials and methods: Type II collagen combined with Freund's adjuvant was applied to induce arthritis in Wistar albino female rats.
Paricalcitol (0.3 μg/kg daily) was subcutaneously injected starting 1 day after collagen applications (prophylactic group) or 1 day after
the onset of arthritis (therapeutic group), until day 29.
Results: The 29th day arthritis scores were lower compared to the 13th day scores in the paricalcitol groups (P < 0.05), while they were
higher in the arthritis group (P < 0.05). Marked cartilage-bone destruction and extensive perisynovial inflammation were detected in
the arthritis group. Decreased cartilage-bone destruction and perisynovial inflammation in the paws were observed in the paricalcitol
groups. The tissue mRNA levels of DKK1, Wnt5a, and axin-2 were higher in the arthritis group than in the control group. In the
paricalcitol groups, mRNA expressions were lower than in the arthritis group.
Conclusion: The present study shows that the Wnt/ß-catenin signaling pathway is active in arthritis. Moreover, paricalcitol ameliorates
arthritis via inhibiting the Wnt/ß-catenin pathway. Paricalcitol and the Wnt/ß-catenin pathway are candidates for research in human
rheumatoid arthritis.
                    

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Makale detayları

Paricalcitol inhibits the Wnt/beta-catenin signaling pathway and ameliorates experimentally induced arthritis

Yazarlar: Servet YOLBAŞ | Ahmet YILDIRIM | Ahmet TEKTEMUR | Zulfinaz Betül ÇELİK | Ebru ÖNALAN ETEM | İbrahim Hanifi ÖZERCAN | Mehmet Mustafa AKIN | Süleyman Serdar KOCA

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 5, pp.1080-1086

Belge Tipi: Makale

Yayın Tarihi: 10/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000750600

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Servet YOLBAŞ | Ahmet YILDIRIM | Ahmet TEKTEMUR | Zulfinaz Betül ÇELİK | Ebru ÖNALAN ETEM | İbrahim Hanifi ÖZERCAN | Mehmet Mustafa AKIN | Süleyman Serdar KOCA

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 5, pp.1080-1086

Belge Tipi:

Makale

Yayın Tarihi:

10/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000750600

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144