Anticancer and antiangiogenesis activities of novel synthesized   2-substituted benzimidazoles molecules

Adem GÜNER; Elifsu POLATLI; Tamer AKKAN; Hakan BEKTAŞ; Canan ALBAY

Makale detayları

Anticancer and antiangiogenesis activities of novel synthesized 2-substituted benzimidazoles molecules

Yazarlar:

Adem GÜNER | Elifsu POLATLI | Tamer AKKAN | Hakan BEKTAŞ | Canan ALBAY

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2019 Vol.43 Issue 5, pp.1270-1289

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000725566

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

In this study, novel 2-substituted benzimidazoles molecules having triazole,   thiadiazole, and oxadiazole rings were synthesized and were evaluated by   anticancer, antioxidant/oxidant status, genotoxicity, and antiangiogenesis   assays. Anticancer activity of the compounds was determined by MTT (0.5, 5,   and 50 μμ\mu g/mL) and lactate dehydrogenase (LDH) release assays against   human prostate and breast cancer cells. Oxidative status of cells was   elicited by total oxidative stress and total antioxidant capacity methods.   Chick chorioallantoic membrane assay was used to evaluate the antiangiogenic   activity. Genotoxicity was evaluated by the sister chromatid exchange (SCE)   and micronucleus (MN) tests in lymphocyte cultured human blood. Our results   showed that some of the compounds synthesized had significant   antiproliferative activity against both cancer cell lines (between 4.54 ±±\pm    0.35 and 20.17 ±±\pm  3.15 μμ\mu g/mL), with higher inhibition of the   breast cancer, and caused inhibition of LDH release with a linear   correlation to MTT results. Moreover, the 5 μμ\mu g/mL dose of these   molecules led to an increase in antioxidant levels. Compounds had   antiangiogenic effectiveness in a dose-dependent manner. Additionally, all   of the compounds did not affect SCE and MN levels compared to controls. In   conclusion, these newly synthesized molecules can be a resource of new   anticancer agents with their nongenotoxic, antiproliferative, and   antiangiogenic properties.

Makale detayları

Anticancer and antiangiogenesis activities of novel synthesized 2-substituted benzimidazoles molecules

Yazarlar: Adem GÜNER | Elifsu POLATLI | Tamer AKKAN | Hakan BEKTAŞ | Canan ALBAY

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2019 Vol.43 Issue 5, pp.1270-1289

Belge Tipi: Makale

Yayın Tarihi: 9/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000725566

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Adem GÜNER | Elifsu POLATLI | Tamer AKKAN | Hakan BEKTAŞ | Canan ALBAY

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2019 Vol.43 Issue 5, pp.1270-1289

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000725566

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527