Resveratrol Attenuates Both Small Bowel and Liver Changes in Obstructive Jaundice

Volkan TEMİ; Erdem OKAY; Abdullah GÜNEŞ; Turgay ŞİMŞEK; Mustafa ÇEKMEN; Ümit BİLGİLİ; Yeşim Gürbüz

doi:https://doi.org/10.5152/balkanmedj.2013.9191

Makale detayları

Resveratrol Attenuates Both Small Bowel and Liver Changes in Obstructive Jaundice

Yazarlar:

Volkan TEMİ | Erdem OKAY | Abdullah GÜNEŞ | Turgay ŞİMŞEK | Mustafa ÇEKMEN | Ümit BİLGİLİ | Yeşim Gürbüz

Yayıncı:

Trakya University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Balkan Medical Journal 2014 Vol.2014 Issue 1, pp.95-99

Belge Tipi:

Makale

Yayın Tarihi:

8/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000760251

Sıklık:

İki Aylık

pISSN:

2146-3123

DOI:

https://doi.org/10.5152/balkanmedj.2013.9191

Özet:

 

Background: It is well known that mucosal changes and alterations in liver function occur in the experimental obstructive jaundice model.    	     	Aims: We aimed to evaluate the effect of resveratrol on obstructive jaundice-induced changes in the small bowel mucosa and liver using ischaemia-modified albumin as a marker of oxidative damage.    	     	Study Design: Animal experimentation.    	     	Methods: The study used a rodent experimental model of obstructive jaundice, including a sham group (1), a control group (2), and a study group (3). Wistar albino rats were used. Jaundice was produced by ligation of the bile duct in Groups 2 and 3. In Group 3, resveratrol was administered intraperitoneally for 14 days.    	     	Results: In terms of the structure and the size of the mucosal villi, significant thickening and blunting were detected in Group 2 compared with Group 1. These changes were significantly less noticeable in Group 3 compared with Group 2. Levels of ischaemia-modified albumin were significantly higher in Group 2 compared with those in Group 1, and they were significantly decreased in Group 3 compared with Group 2.    	     	Conclusion: Resveratrol administration to obstructive jaundiced rats reduced the organic effects of obstructive jaundice on small bowel mucosa and liver oxidative stress. We believe that this reduction might attenuate bacterial translocation and systemic effects of secreted cytokines. (Balkan Med J 2014;31:95-99).

Makale detayları

Resveratrol Attenuates Both Small Bowel and Liver Changes in Obstructive Jaundice

Yazarlar: Volkan TEMİ | Erdem OKAY | Abdullah GÜNEŞ | Turgay ŞİMŞEK | Mustafa ÇEKMEN | Ümit BİLGİLİ | Yeşim Gürbüz

Yayıncı: Trakya University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Balkan Medical Journal 2014 Vol.2014 Issue 1, pp.95-99

Belge Tipi: Makale

Yayın Tarihi: 8/2014

Belge Dili: İngilizce

Document ID (Org No.): 2000760251

Sıklık: İki Aylık

pISSN: 2146-3123

DOI: https://doi.org/10.5152/balkanmedj.2013.9191

Sayı

Yazarlar:

Volkan TEMİ | Erdem OKAY | Abdullah GÜNEŞ | Turgay ŞİMŞEK | Mustafa ÇEKMEN | Ümit BİLGİLİ | Yeşim Gürbüz

Yayıncı:

Trakya University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Balkan Medical Journal 2014 Vol.2014 Issue 1, pp.95-99

Belge Tipi:

Makale

Yayın Tarihi:

8/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000760251

Sıklık:

İki Aylık

pISSN:

2146-3123

DOI:

https://doi.org/10.5152/balkanmedj.2013.9191